Malondialdehyde reacts readily with amino acids to form adducts containing vinylogous amidine linkages. Crosslinking reactions between nucleic acid bases, and amino acids induced by malondialdehyde also have been investigated. The physical data obtained for the adducts provide structural information on the possible mode of crosslinking of proteins and nucleic acids induced by this lipid metabolite.
AbstractDer Dialdehyd (I) reagiert mit α‐Aminosäuren, wie z.B. dem Glycinester (II), zum Enaminal (III) mit Geschwindigkeitskonstanten von k = 2.51/M ′ min, aber nicht zum 2:1‐ Produkt.
A novel structural analogue of cyclic AMP has been synthesized. This compound has been found to activate protein kinase from skeletal muscle (Ka 5.0 microM). It is virtually resistant to degradation by beef heart cAMP phosphodiesterase. It is an inhibitor of this enzyme with an [I]50 of 47.0 microM. The proliferation of cancer cells (HT-29) is inhibited by this compound. It represents the first example of a 2',3'-cyclic nucleotide with marked biological activity.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalogenation of N-oxygenated pyrazoles. Preparation of N-oxygenated 4-halopyrazole and 4,4-dihalo-4H-pyrazole derivativesJohn F. Hansen, Yong In Kim, Linus J. Griswold, Gary W. Hoelle, Deborah L. Taylor, and David E. ViettiCite this: J. Org. Chem. 1980, 45, 1, 76–80Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/jo01289a017https://doi.org/10.1021/jo01289a017research-articleACS PublicationsRequest reuse permissionsArticle Views505Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeuterium lock-channel nuclear magnetic resonance thermometers for multinuclear spectrometersGerald A. Pearson and David E. ViettiCite this: Anal. Chem. 1978, 50, 12, 1717–1719Publication Date (Print):October 1, 1978Publication History Published online1 May 2002Published inissue 1 October 1978https://pubs.acs.org/doi/10.1021/ac50034a042https://doi.org/10.1021/ac50034a042research-articleACS PublicationsRequest reuse permissionsArticle Views62Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and oxidation of 1-hydroxypyrazoles and 1-hydroxypyrazole 2-oxidesJohn F. Hansen and David E. ViettiCite this: J. Org. Chem. 1976, 41, 17, 2871–2873Publication Date (Print):August 1, 1976Publication History Published online1 May 2002Published inissue 1 August 1976https://doi.org/10.1021/jo00879a016RIGHTS & PERMISSIONSArticle Views141Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (396 KB) Get e-Alerts Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of a new 1-hydroxypyrazole 2-oxide via chelationJohn F. Hansen and David E. ViettiCite this: J. Org. Chem. 1975, 40, 6, 816–817Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://doi.org/10.1021/jo00894a041RIGHTS & PERMISSIONSArticle Views46Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (265 KB) Get e-Alertsclose Get e-Alerts