Poly(2-hydroxyethyl methacrylate) (poly(HEMA)) has been characterised by means of electrospray ionisation-mass spectrometry/mass spectrometry (ESI-MS/MS), in order to evaluate this technique for the generation of end group information. Low energy collision-induced dissociation (CID) data from poly(HEMA) enabled information on both end groups of the polymer chain to be gleaned, in a similar fashion to that proposed previously for other methacrylate polymer systems. Exact-mass CID information was employed to aid the understanding of the dissociation mechanism of the polymer. Some additional fragmentation pathways, compared to other methacrylate polymer systems, are proposed. An example of how software can aid the interpretation of the MS/MS data is also shown.

There is a clinical need for synthetic scaffolds that will promote bone regeneration. Important factors include obtaining an optimal porosity and size of interconnecting windows whilst maintaining scaffold mechanical strength, enabling complete penetration of cells and nutrients throughout the scaffold, preventing the formation of necrotic tissue in the centre of the scaffold. To address this we investigated varying slip deflocculation in order to control the resulting porosity, pore size and interconnecting window size whilst maintaining mechanical strength. Hydroxyapatite (HA) porous ceramics were prepared using a modified slip casting process. Rheological measurements of the HA slips were used to identify deflocculation conditions which resulted in changes in the cell and window sizes of the resulting ceramics. Sintered ceramics were characterised by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Pore and window size distribution was determined by SEM. XRD analysis confirmed that the crystal structure remained HA after the sintering process. SEM showed that HA porous ceramics presented a highly interconnected porous network with average pore sizes ranging from 391±39 to 495±25μm. The average window size varied from 73±5 to 135±7μm. Pore diameters obtained were controllable in the range 200–500μm. Window sizes were in the range 30–250μm. The use of dispersant concentration allows pore and window size to be modified whilst maintaining control over porosity demonstrated by a porosity of 85% for seven different dispersant concentrations. The advantage of this approach allows the correlation between the rheological conditions of the slip and the resultant sintered ceramic properties. In particular, optimising the ceramic strength by controlling the agglomeration during the casting process.

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTNew Thiolate−Cobalt(II) Complexes for Catalytic Chain Transfer Polymerization of Methyl MethacrylateWenxin Wang, Philip A. Stenson, Armando Marin-Becerra, Jonathan McMaster, Martin Schröder, Derek J. Irvine, David Freeman, and Steven M. HowdleView Author Information School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K., and Uniqema R&D Department, The Wilton Research Centre, Wilton, Redcar, TS10 4RF, U.K. Cite this: Macromolecules 2004, 37, 18, 6667–6669Publication Date (Web):August 12, 2004Publication History Received15 April 2004Revised20 July 2004Published online12 August 2004Published inissue 1 September 2004https://doi.org/10.1021/ma049267zCopyright © 2004 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views489Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (46 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Organic compounds,Polymerization,Polymers,Radical polymerization Get e-Alerts