Sm-p80-based vaccine efficacy for Schistosoma mansoni was evaluated in a baboon model of infection and disease. The study was designed to replicate a human vaccine implementation scenario for endemic regions in which vaccine would be administered following drug treatment of infected individuals. In our study, the Sm-p80-based vaccine reduced principal pathology producing hepatic egg burdens by 38.0% and egg load in small and large intestines by 72.2% and 49.4%, respectively, in baboons. Notably, hatching rates of eggs recovered from liver and small and large intestine of vaccinated animals were significantly reduced, by 60.4%, 48.6%, and 82.3%, respectively. Observed reduction in egg maturation/hatching rates was supported by immunofluorescence and confocal microscopy showing unique differences in Sm-p80 expression in worms of both sexes and matured eggs. Vaccinated baboons had a 64.5% reduction in urine schistosome circulating anodic antigen, a parameter that reflects worm numbers/health status in infected hosts. Preliminary analyses of RNA sequencing revealed unique genes and canonical pathways associated with establishment of chronic disease, praziquantel-mediated parasite killing, and Sm-p80-mediated protection in vaccinated baboons. Overall, our study demonstrated efficacy of the Sm-p80 vaccine and provides insight into some of the epistatic interactions associated with protection.

Annals of the New York Academy of SciencesVolume 1425, Issue 1 p. i-i COVER IMAGEFree Access Cover Image, Volume 1425, Issue 1 Arif J. Siddiqui, Arif J. SiddiquiSearch for more papers by this authorAdebayo J. Molehin, Adebayo J. MolehinSearch for more papers by this authorWeidong Zhang, Weidong ZhangSearch for more papers by this authorPramodh K. Ganapathy, Pramodh K. GanapathySearch for more papers by this authorEunjee Kim, Eunjee KimSearch for more papers by this authorJuan U. Rojo, Juan U. RojoSearch for more papers by this authorWhitni K. Redman, Whitni K. RedmanSearch for more papers by this authorSouad R. Sennoune, Souad R. SennouneSearch for more papers by this authorJustin Sudduth, Justin SudduthSearch for more papers by this authorJasmin Freeborn, Jasmin FreebornSearch for more papers by this authorDerick Hunter, Derick HunterSearch for more papers by this authorKameswara R. Kottapalli, Kameswara R. KottapalliSearch for more papers by this authorPratibha Kottapalli, Pratibha KottapalliSearch for more papers by this authorRuwanthi Wettashinghe, Ruwanthi WettashingheSearch for more papers by this authorGovert J. van Dam, Govert J. van DamSearch for more papers by this authorPaul L.A.M. Corstjens, Paul L.A.M. CorstjensSearch for more papers by this authorJames F. Papin, James F. PapinSearch for more papers by this authorDavid Carey, David CareySearch for more papers by this authorWorkineh Torben, Workineh TorbenSearch for more papers by this authorGul Ahmad, Gul AhmadSearch for more papers by this authorAfzal A. Siddiqui, Afzal A. SiddiquiSearch for more papers by this author Arif J. Siddiqui, Arif J. SiddiquiSearch for more papers by this authorAdebayo J. Molehin, Adebayo J. MolehinSearch for more papers by this authorWeidong Zhang, Weidong ZhangSearch for more papers by this authorPramodh K. Ganapathy, Pramodh K. GanapathySearch for more papers by this authorEunjee Kim, Eunjee KimSearch for more papers by this authorJuan U. Rojo, Juan U. RojoSearch for more papers by this authorWhitni K. Redman, Whitni K. RedmanSearch for more papers by this authorSouad R. Sennoune, Souad R. SennouneSearch for more papers by this authorJustin Sudduth, Justin SudduthSearch for more papers by this authorJasmin Freeborn, Jasmin FreebornSearch for more papers by this authorDerick Hunter, Derick HunterSearch for more papers by this authorKameswara R. Kottapalli, Kameswara R. KottapalliSearch for more papers by this authorPratibha Kottapalli, Pratibha KottapalliSearch for more papers by this authorRuwanthi Wettashinghe, Ruwanthi WettashingheSearch for more papers by this authorGovert J. van Dam, Govert J. van DamSearch for more papers by this authorPaul L.A.M. Corstjens, Paul L.A.M. CorstjensSearch for more papers by this authorJames F. Papin, James F. PapinSearch for more papers by this authorDavid Carey, David CareySearch for more papers by this authorWorkineh Torben, Workineh TorbenSearch for more papers by this authorGul Ahmad, Gul AhmadSearch for more papers by this authorAfzal A. Siddiqui, Afzal A. SiddiquiSearch for more papers by this author First published: 10 August 2018 https://doi.org/10.1111/nyas.13959AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume1425, Issue1Special Issue: Annals ReportsAugust 2018Pages i-i RelatedInformation