Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HDL-C). This communication will describe the SAR and synthesis of a series of substituted tetrahydroquinoxaline CETP inhibitors from early mu lead to advanced enantiomerically pure analogs.

FIELD: chemistry. SUBSTANCE: invention can be applied in medicine and concerns inhibitors of MaR-kinase p38 of formula where W represents N or O, when Y represents C, and W represents C, when Y represents N; U represents CH or N; V represents C-E or N; X represents O, S, SO, SO 2 , NH, C=O,-C=NOR 1 or CHOR 1 ; B represents H or NH 2 ; R 1 , E and A stands for H or various alkyl, heteroalkyl, aromatic and heteroaromatic substitutes. EFFECT: production of new biologically active compounds. 48 cl, 138 ex, 54 dwg