ChemInformVolume 36, Issue 17 Preparative Organic Chemistry Difluorocarbene-Induced Facile Synthesis of Chlorohydrins from Glycidyl Ethers. Sapna Singh, Sapna Singh Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorPinaki S. Bhadury, Pinaki S. Bhadury Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorMamta Sharma, Mamta Sharma Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorMeehir Palit, Meehir Palit Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorDevendra K. Jaiswal, Devendra K. Jaiswal Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this author Sapna Singh, Sapna Singh Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorPinaki S. Bhadury, Pinaki S. Bhadury Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorMamta Sharma, Mamta Sharma Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorMeehir Palit, Meehir Palit Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this authorDevendra K. Jaiswal, Devendra K. Jaiswal Synth. Chem. Div., Def. Res. Dev. Establ., Gwalior 474 002, IndiaSearch for more papers by this author First published: 05 April 2005 https://doi.org/10.1002/chin.200517070Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume36, Issue17April 26, 2005 RelatedInformation

OBJECTIVE: To study the cardio-respiratory effects of DRDE-07, a new prophylactic agent for sulphur mustard. MATERIAL AND METHODS: The effect of DRDE-07 was studied in anesthetized male rats (Wistar), by administering it either by intraperitoneal or oral routes. Different doses (0.25, 0.5, 1.0 and 2.0 LD50) were used and various cardio-respiratory parameters viz., mean arterial blood pressure, heart rate, respiratory rate and tidal volume were monitored on an oscillograph. RESULTS: Intraperitoneal administration of 0.5 and 1.0 LD50 and oral administration of 0.25 LD50 of DRDE-07 did not produce any effect on the cardio-respiratory variables. Oral administration of 0.5 and 1.0 LD50 showed a significant decrease in mean arterial blood pressure after 60 min. None of the animals died in the two-hour monitoring period. Two (2.0) LD50 administration of DRDE-07 either by intraperitoneal or oral routes induced a sudden decrease in the mean arterial blood pressure and the animals died within one hour. CONCLUSION: DRDE-07 did not show any significant effect on the cardio-respiratory variables at a dose of 0.25 LD50 by oral route and 1.0 LD50 by intraperitoneal route. The death after intraperitoneal or oral administration (2.0 LD50) of DRDE-07 is due to the sudden fall in the mean arterial blood pressure.

Novel diamine monomers, 1,3-bis[3′-trifluoromethyl-4′(4″-amino benzoxy) benzyl] benzene (IV) and 4,4-bis[3′-trifluoromethyl-4′(4-amino benzoxy) benzyl] biphenyl (V) have been synthesized. These monomers lead to several novel fluorinated polyimides on reaction with different commercially available dianhydrides like pyromellatic dianhydride (PMDA), benzophenone tetracarboxylic acid dianhydride (BTDA) or 2,2-bis(3,4-dicarboxyphenyl) hexafluoropropane (6FDA). The polyimides prepared from above two monomers on reaction with 6FDA are soluble in several organic solvents such as N,N-dimethyl formamide (DMF), N,N-dimethyl acetamide (DMAc) and tetrahydrofuran (THF). The polyimides prepared from PMDA/IV is soluble in DMF and N-methyl pyrollidone (NMP) on heating, whereas V/PMDA is insoluble in all solvents. BTDA/IV polyimide is also soluble in NMP, DMF and DMAc. These polyimide films have low water absorption rate 0.2–0.7% and low dielectric constant 2.74–3.2 at 1MHz. These polyimides showed very high thermal stability even up to 531°C for 5% weight loss in synthetic air and glass transition temperature up to 316°C (by DSC) in nitrogen. All polyimides formed tough transparent films, with tensile strength up to 148MPa, a modulus of elasticity up to 2.6GPa and elongation at break up to 31% depending upon the exact repeating unit structure.

Gallium arsenide (GaAs), a group III-VA intermetallic semiconductor, possesses superior electronic and optical properties and has a wide application in the electronics industry. Exposure to GaAs in the semiconductor industry is a potential occupational hazard because cleaning and slicing GaAs ingots to yield the desired wafer could generate GaAs particles. The ability of GaAs to induce oxidative stress has not yet been reported. The present study reports the role of oxidative stress in GaAs-induced haematological and liver disorders and its possible reversal overturn by administration of meso-2,3-dimercaptosuccinic acid (DMSA) and one of its analogue, monoisoamyl DMSA (MiADMSA), either individually or in combination with oxalic acid. While DMSA and MiADMSA are potential arsenic chelators, oxalic acid is reported to be an effective gallium chelator. Male rats were exposed to 10 mg/kg GaAs orally, 5 days a week for 8 weeks. GaAs exposure was then stopped and rats were given a 0.5 mmol/kg dose of succimers (DMSA or MiADMSA), oxalic acid or a combination of the two, intraperitoneally once daily for 5 consecutive days. We found a significant fall in blood delta-aminolevulinic acid dehydratase (ALAD) activity and blood glutathione (GSH) level, and an increased urinary excretion of delta-aminolevulinic acid (ALA) and an increased malondialdehyde (MDA) level in erythrocytes of rats exposed to GaAs. Hepatic GSH levels decreased, whereas there was an increase in GSSG and MDA levels. The results suggest a role of oxidative stress in GaAs-induced haematological and hepatic damage. Administration of DMSA and MiADMSA produced effective recovery in most of the above variables. However, a greater effectiveness of the chelation treatment (i.e. removal of both gallium and arsenic from body organs) could be achieved by combined administration of succimer (DMSA) with oxalic acid since, after MiADMSA administration, a marked loss of essential metals (copper and zinc) is of concern.

In an attempt to develop effective antidotes against organophosphorous intoxication, three new structurally related bispyridinium mono-oximes with a 2-oxopropane bridge were synthesized. The compounds were evaluated for in-vivo therapeutic protection and cholinesterase reactivation in blood and various brain regions. In neuromuscular function studies against diisopropyl-fluorophosphate and isopropyl methylphosphonofluoridate poisoning, the oximes produced significant protection. The compounds produced marked peripheral reactivation and beneficial effects on neuromuscular transmission. The reactivation of cholinesterase in cerebral cortex by the oximes, in spite of their being quaternary salts is a notable feature.