Sensorineural hearing loss is a major public health concern, yet its treatment remains limited by the anatomical complexity and biological barriers protecting the cochlea. Among these, the round window membrane (RWM) constitutes a key interface for local drug delivery to the inner ear. However, passive diffusion via intratympanic injection is often insufficient, particularly for hydrophilic, large, or negatively charged molecules such as gene therapy vectors. This systematic review aimed to evaluate biomechanical and biochemical strategies to enhance RWM permeability for more efficient and targeted drug delivery to the inner ear, including direct permeability modulation of the RWM properties or indirect enhancement mechanisms increasing drug delivery without altering intrinsic membrane permeability. Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, a comprehensive literature search was conducted using the Scopus, MEDLINE/PubMed, Cochrane, and CINAHL electronic databases. In vivo studies and clinical trials involving biochemical or biomechanical strategies to enhance RWM permeability were included. Risk of bias was assessed using the SYRCLE (Systematic Review Center for Laboratory Animal Experimentation) tool. Out of 1776 screened articles, 89 met the inclusion criteria. Four biochemical approaches and three biomechanical strategies were identified, respectively: (1) hydrogels, thermogels, and emulsions, (2) nanosystems, (3) microsystems, and (4) permeabilizers, and (1') sonoporation, (2') acoustic stimulation, and (3') magnetic systems. Most studies reported improved drug delivery to the inner ear or therapeutic efficacy. While earlier research focused on hydrogels, thermogels, emulsions, permeabilizers, and acoustic stimulation for small molecules such as corticoids and antioxidants, recent studies increasingly explore nanosystems, microsystems, sonoporation, and magnetic methods to facilitate the delivery of larger agents, including gene therapy. This review also highlights that while many strategies are already available and effective in animal models, further research is essential to facilitate the clinical translation of both existing and emerging delivery methods.

Three-dimensional (3D) (bio)printing has emerged as a relevant approach in bone tissue regeneration, enabling the precise fabrication of biomimetic scaffolds. The incorporation of extracellular vesicles (EVs) into 3D-(bio)printed constructs represents a promising cell-free strategy to enhance bone regeneration. EVs, as natural mediators of intercellular communication, contribute to osteogenesis, angiogenesis, and immune modulation. This review aims to evaluate current evidence on the use of EVs-enhanced 3D (bio)printing for bone regeneration. The literature search was conducted across different databases. In vitro and in vivo studies using EVs-containing (bio)printed constructs to assess osteogenic differentiation and/or bone regeneration were included. Out of 552 articles, 35 met the inclusion criteria. Most EVs were derived from bone marrow mesenchymal stem cells and were incorporated into scaffolds either before or after printing. Extrusion-based bioprinting was the most commonly used method. Nearly all studies reported enhanced osteogenic differentiation and bone formation in EV-treated groups, underscoring their therapeutic potential. EVs-based bioinks retain the regenerative benefits of stem cells while avoiding challenges associated to cell-based therapies. Despite encouraging results, standardization in EV isolation, storage, and delivery remains crucial for clinical translation. This review highlights the growing significance of EVs in regenerative medicine and identifies key areas for future research and development.

Objective Hypercementosis, characterized by excessive cementum deposition that distorts apical root morphology, poses specific anatomical challenges in endodontics; this systematic review aimed to synthesize its endodontic implications and to propose tailored treatment strategies for affected teeth. Methods A systematic search was conducted across PubMed, Scopus, EBSCO-DOSS, and Google Scholar following PRISMA guidelines. The SPIDER tool was used to refine inclusion criteria, focusing on studies involving human teeth affected by hypercementosis and its impact on endodontic treatment. Results Ten studies met the inclusion criteria: three experimental/descriptive and seven clinical studies. Hypercementosis was associated with anatomical challenges, complicating working length determination, canal negotiation, and obturation. Reported treatment approaches included orthograde treatment, surgical endodontics [including computer-aided-design-guided microsurgery], and the use of Cone Beam Computed Tomography for enhanced visualization of root morphology. Despite these interventions, treatment outcomes remained limited by persistent anatomical complexities. Conclusions Hypercementosis presents a significant challenge in endodontic treatment. A stepwise approach, ranging from clinical monitoring in asymptomatic cases to surgical interventions is recommended. The integration of advanced imaging technologies and individualized treatment planning is essential to improving therapeutic outcomes. Larger cohort studies with standardized diagnostic criteria are needed to better assess the prevalence of hypercementosis and its incidence on endodontic treatment.

ABSTRACT Objectives To describe the stress and confidence of dental students during the management of an endodontic emergency (EE) and investigate the associated factors. Methods This cross‐sectional study included 227 undergraduate dental students undergoing clinical training (i.e., in the fourth, fifth, or sixth year) who responded to questions asking for their overall level of stress during an EE and their level of confidence in their ability to manage 50 steps of EE management related to communication and technical skills, and clinical examination and decision‐making. Results Managing EE was perceived as slightly or fairly stressful by 70% of the fourth‐ to sixth‐year students. The fourth‐ and fifth‐year students felt significantly greater stress ( p = 0.026) and lower confidence ( p < 0.001) than the sixth‐year students, as did women ( p < 0.001 for both). No significant difference in stress or confidence levels was observed across the clinical training environments evaluated. Just over half of the students reported being confident about discussing a case with their teacher. The situations in which students felt least confident were patient management, crack detection, lymph node palpation, locoregional or intrapulpal anaesthesia, and intraoral drainage, and those in which students gained the most confidence in the sixth year compared to the lower grades were clinical decision‐making. Conclusions Managing EE was perceived as slightly or fairly stressful for most students, and stress decreased, while confidence increased in the 3 years of clinical training. Although these findings are positive for the existing training program, there is still work to be done to improve students' learning experiences, especially on teacher receptiveness.

Maxillofacial defects, located in a region characterized by a complex interplay of soft and hard tissues, along with a sophisticated capillary and neural network, have long posed significant challenges in both clinical practice and research [...]

Despite significant advances in the management of patients with oral cancer, maxillofacial reconstruction after ablative surgery remains a clinical challenge. In bone tissue engineering, biofabrication strategies have been proposed as promising alternatives to solve issues associated with current therapies and to produce bone substitutes that mimic both the structure and function of native bone. Among them, laser-assisted bioprinting (LAB) has emerged as a relevant biofabrication method to print living cells and biomaterials with micrometric resolution onto a receiving substrate, also called 'biopaper'. Recent studies have demonstrated the benefits of prevascularization using LAB to promote vascularization and bone regeneration, but mechanical and biological optimization of the biopaper are needed. The aim of this study was to apply gelatin-sheet fabrication process to the development of a novel biopaper able to support prevascularization organized by LAB for bone tissue engineering applications. Gelatin-based sheets incorporating bioactive glasses (BGs) were produced using various freezing methods and crosslinking (CL) parameters. The different formulations were characterized in terms of microstructural, physical, mechanical, and biological properties in monoculture and coculture. Based on multi-criteria analysis, a rank scoring method was used to identify the most relevant formulations. The selected biopaper underwent additional characterization regarding its ability to support mineralization and vasculogenesis, its bioactivity potential and in vivo degradability. The biopaper 'Gel5wt% BG1wt%-slow freezing-CL160 degrees C 24 h ' was selected as the best candidate, due to its suitable properties including high porosity (91.69 +/- 1.55%), swelling ratio (91.61 +/- 0.60%), Young modulus (3.97 x 104 +/- 0.97 x 104 Pa) but also its great cytocompatibility, osteogenesis and bioactivity properties. The preorganization of human umbilical vein endothelial cell using LAB onto this new biopaper led to the formation of microvascular networks. This biopaper was also shown to be compatible with 3D-molding and 3D-stacking strategies. This work allowed the development of a novel biopaper adapted to LAB with great potential for vascularized bone biofabrication.

Transtympanic administration is used clinically for the injection of gentamicin and/or corticosteroids. This atraumatic route is based on passive diffusion through the round window membrane (RWM). The main limitation of this method is related to the clearance through the Eustachian tube, making the concentration of the therapeutic agent at the intracochlear level uncertain and limited. Moreover, this technique remains unsuitable for molecules of high molecular weight or in the case of gene therapies. The purpose was to study a new technique of intracochlear administration in an atraumatic, direct and controlled manner by laser-assisted bioprinting (LAB). LAB was used to deliver dexamethasone phosphate with thermosensitive hydrogel on the mouse RWM. After validation of the regularity and homogeneity of the pattern, the diffusion in vivo of the dexamethasone into the perilymph after LAB has been confirmed by ELISA. Auditory function measurements showed no hearing impairment suggesting that bioprinting does not induce significant cochlear damage. Hence, the present proof of concept study introduces a promising approach for inner ear drug delivery.

The laser patterning of implant materials for bone tissue engineering purposes has proven to be a promising technique for controlling cell properties such as adhesion or differentiation, resulting in enhanced osteointegration. However, the possibility of patterning the bone tissue side interface to generate microstructure effects has never been investigated. In the present study, three different laser-generated patterns were machined on the bone surface with the aim of identifying the best surface morphology compatible with osteogenic-related cell recolonization. The laser-patterned bone tissue was characterized by scanning electron microscopy and confocal microscopy in order to obtain a comprehensive picture of the bone surface morphology. The cortical bone patterning impact on cell compatibility and cytoskeleton rearrangement on the patterned surfaces was assessed using Stromal Cells from the Apical Papilla (SCAPs). The results indicated that laser machining had no detrimental effect on consecutively seeded cell metabolism. Orientation assays revealed that patterns with larger hatch distances were correlated with higher cell cytoskeletal conformation to the laser-machined patterns. To the best of our knowledge, this study is the first to consider and evaluate bone as a biological interface that can be engineered for improvement. Further investigations should focus on the in vivo implications of this direct patterning.

Cocultures of human gingival fibrobasts (hGF) and endothelial cells could enhance regeneration and repair models as well as improve vascularization limitations in tissue engineering. The aim of this study was to assess if hGF could support formation of stable vessel-like networks. Explant primary hGF were isolated from gum surgical wastes collected from healthy patients with no history of periodontitis. Human umbilical vein endothelial cells (HUVEC) were two-dimensional (2D) and three-dimensional (3D) cocultured in vitro with hGF at a cell ratio of 1:1 and medium of 1:1 of their respective media during at least 31 days. Vessel quantification of HUVEC networks was performed. In order to investigate the pericyte-like properties of hGF, the expression of perivascular markers α-SMA, NG2, CD146 and PDGFR-β was studied using immunocytochemistry and flow cytometry on 2D cultures. hGF were able to support a long-lasting HUVEC network at least 31 days, even in the absence of a bioreactor with flow. As observed, HUVEC started to communicate with each other from day 7, constructing a network. Their interconnection increased significantly between day 2 and day 21 and lasted beyond the 31 days of observation. Moreover, we tried to explain the stability of the networks obtained and showed that a small population of hGF in close vicinity of HUVEC networks expressed perivascular markers. These findings highlight a new interesting property concerning hGF, accentuating their relevance in tissue engineering and periodontal regeneration. These promising results need to be confirmed using more 3D applications and in vivo testing.

The generation of liquid jets and drops using tightly focused femtosecond laser pulses near a liquid-air interface is a convenient contactless solution for printing functional materials as well as bio-materials. Jets and drops emerge following the nucleation of a cavitation bubble in the liquid bulk by a laser-induced plasma. During the initial expansion of the bubble, a thin and fast jet is produced at the liquid surface. Moments later a second thick and slow jet emanates from the surface when the bubble has nearly deflated. Despite potential applications, little is known about the mechanism behind this complex phenomenology. Here, experiments and simulations are used to investigate this two-jet process. Counter-intuitively, the second jet is not the result of bubble expansion, as with the first jet, but originates from the secondary flows induced by the bubble dynamics. Our study links the second jet properties to the control parameters of the problem and establishes a phase diagram for its emergence.

Grafts aside, current strategies employed to overcome bone loss still fail to reproduce native tissue physiology. Among the emerging bioprinting strategies, laser-assisted bioprinting (LAB) offers very high resolution, allowing designing micrometric patterns in a contactless manner, providing a reproducible tool to test ink formulation. To this date, no LAB associated ink succeeded to provide a reproducible ad integrum bone regeneration on a murine calvaria critical size defect model. Using the Conformité Européenne (CE) approved BioRoot RCS® as a mineral addition to a collagen-enriched ink compatible with LAB, the present study describes the process of the development of a solidifying tricalcium silicate-based ink as a new bone repair promoting substrates in a LAB model. This ink formulation was mechanically characterized by rheology to adjust it for LAB. Printed aside stromal cells from apical papilla (SCAPs), this ink demonstrated a great cytocompatibility, with significant in vitro positive impact upon cell motility, and an early osteogenic differentiation response in the absence of another stimulus. Results indicated that the in vivo application of this new ink formulation to regenerate critical size bone defect tends to promote the formation of bone volume fraction without affecting the vascularization of the neo-formed tissue. The use of LAB techniques with this ink failed to demonstrate a complete bone repair, whether SCAPs were printed or not of at its direct proximity. The relevance of the properties of this specific ink formulation would therefore rely on the quantity applied in situ as a defect filler rather than its cell modulation properties observed in vitro . For the first time, a tricalcium silicate-based printed ink, based on rheological analysis, was characterized in vitro and in vivo , giving valuable information to reach complete bone regeneration through formulation updates. This LAB-based process could be generalized to normalize the characterization of candidate ink for bone regeneration.

As the need for efficient, sustainable, customizable, handy and affordable substitute materials for bone repair is critical, this systematic review aimed to assess the use and outcomes of silica-derived inks to promote in vivo bone regeneration. An algorithmic selection of articles was performed following the PRISMA guidelines and PICO method. After the initial selection, 51 articles were included. Silicon in ink formulations was mostly found to be in either the native material, but associated with a secondary role, or to be a crucial additive element used to dope an existing material. The inks and materials presented here were essentially extrusion-based 3D-printed (80%), and, overall, the most investigated animal model was the rabbit (65%) with a femoral defect (51%). Quality (ARRIVE 2.0) and risk of bias (SYRCLE) assessments outlined that although a large majority of ARRIVE items were “reported”, most risks of bias were left “unclear” due to a lack of precise information. Almost all studies, despite a broad range of strategies and formulations, reported their silica-derived material to improve bone regeneration. The rising number of publications over the past few years highlights Si as a leverage element for bone tissue engineering to closely consider in the future.

Development of dexterity, hand-eye coordination and self-assessment are essential during the preclinical training of dental students. To meet this requirement, dental simulators have been developed combining virtual reality with a force feedback haptic interface. The aim of this study was to assess the capability of the VirTeaSy© haptic simulator to discriminate between users with different levels of practical and clinical experience.Fifty-six volunteers divided into five groups (non-dentists, 1st/3rd/final-year dental students, recent graduates) had three attempts to prepare an occlusal amalgam cavity using the simulator. Percentages of volumes prepared inside (%IV) and outside (%OV) the required cavity, skill index and progression rate, referring to the evolution of skill index between trials 1 and 3, were assessed. The dental students and recent graduates completed a questionnaire to gather their opinions about their first hands-on experience with a haptic simulator.The results showed no significant difference between the groups at the first attempt. Following the third attempt, the skill index was improved significantly. Analysis of progression rates, characterised by large standard deviations, did not reveal significant differences between groups. The third attempt showed significant differences in skill index and %IV between 1st-year undergraduate dental students and both non-dentists and recent dental graduates. The questionnaire indicated a tendency for dental operators to consider the simulator as a complement to their learning and not a substitute for traditional methods.This study did not show the ability of a basic aptitude test on VirTeaSy© haptic simulator to discriminate between users of different levels of expertise. Optimisations must be considered in order to make simulation-based assessment clinically relevant.

BackgroundTuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder. Due to the various manifestations of TSC and their potential complications, a multidisciplinary care approach is recommended by consensus guidelines.ObjectivesOur study aimed to give a complete description of our TSC adult cohort and to evaluate the multidisciplinary and interdisciplinary management model.MethodsData on each adult patient diagnosed with TSC, including disease manifestations, interventions and outcomes, were collected at baseline and updated annually. A multidisciplinary TSC approach with all the recommended explorations was carried out annually.Results90 patients were enrolled in Centre Hospitalier Universitaire de Bordeaux, between January 2000 and September 2018. Median age of patients at inclusion was 37 years (range, 27–47) and 20 years old at diagnosis of TSC. Regarding the occurrence of TSC manifestations, 97% of the patients had cutaneous lesions, 89% had neurological manifestations, 83% had renal manifestations and 100% had dental lesions with pits. More than half the patients had sclerotic bone lesions (68%), TSC-associated neuropsychiatric disorders (64%) and lymphangioleiomyomatosis (59%). A TSC multidisciplinary approach was developed including a global follow-up and an evaluation of TSC targeting organs, according to the recommendations. A satisfaction survey revealed global and entire satisfaction of patients with TSC.ConclusionWe obtained an accurate description of a cohort of adult patients with TSC. Our multidisciplinary approach model allowed us to provide optimal management of patients with TSC with a high level of patient satisfaction.

Orofacial involvement is common and often understated in the treatment guidelines of systemic sclerosis. It impairs daily quality of life by having repercussions on comfort, nutrition, aesthetics and self-confidence. The three most frequent features observed in patients are a severe limitation of mouth opening, periodontal diseases and an increased xerostomia (sometimes due to secondary Sjögren’s syndrome). Complaints about dry mouth sensation or limited mouth opening are common clinical situations that can be difficult to manage. Furthermore, handgrip impairment leads to a deficient oral hygiene that can aggravate already existing oral diseases. This chapter aims at (a) describing the main orofacial consequences of systemic sclerosis and (b) giving keys to early diagnosis and management of these features. Different clinical situations will be exposed to identify the main clinical signs to investigate. Early diagnosis is possible thanks to a strong collaboration between rheumatologists and dental surgeons and will lead to early management. Prevention and oral hygiene are the keys to avoid complicated and invasive procedures. Even if oral complications are unpredictable, early and wide dissemination of information about those issues to patients from the time of diagnosis could prevent massive complications.

Extensive dental and periodontal defects are frequent and with a limited regenerative potential. Tissue engineering could be a promising tool to obtain personalized oral grafts. However, current research shows a lack ofin vitroengineered oral tissues. This is explained by the difficulty to engineer blood vessel systems, impairing the connection to the host tissue and the graft success. Various strategies were used to engineer vascularized tissues and reported successful results, thus needing a clear analysis of the current state of art in oral tissue engineering. This systematic review aimed at studying the critical factors and techniques used to engineer a prevascularized oral tissue graft. PubMed, Cochrane Library, and SCOPUS databases were searched over the last 5 years following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Out of 638 screened studies, 24 were included in the systematic review according to strict inclusion and exclusion criteria and focusing on higher connection to the host vasculature. Animal models were all rodents, and subcutaneous implantation was the most used intervention. Studies presented low-to-unclear risk of bias according to the Systematic Review Center for Laboratory Animal Experimentation tool. Endothelial cells were mainly human umbilical vein endothelial cells, while stromal cells were most of the time oral or mesenchymal stem cells. Coculture of both types of cells at a 1:1 ratio was the most common technique used to obtain vascular networks, and some studies precultured grafts up to 3 weeks to enable network formation before implantation. Prevascularized grafts were produced by various tissue engineering technologies, including cell seeding and/or embedding, cell sheets, and spheroids. All studies reported a statistically significant faster and higher connection to host of prevascularized constructs compared to controls. Vessel networks were indeed denser, with a higher portion of lumen containing erythrocytes and blood flow increased. By assessing the relevant studies on the subject, this systematic review showed that engineered prevascularization proved to be an interesting approach to improve graft connection to the host vasculature and respective specific cell and scaffold criteria. Further studies on enhanced scaffolds and larger animals seem necessary to confirm these promising results with more voluminous grafts and get closer to native human tissues and applications. Impact statement Autologous oral grafts display limitations in terms of revascularization and morbidity of donor sites, despite being the gold standard. This systematic review aimed at clarifying existing data regarding techniques to engineer prevascularized oral grafts. Tissue engineering techniques, using cocultures of endothelial and oral stromal cells, proved to be an efficient way to enhance and accelerate the connection of the graft to the host vasculature. Engineered prevascularization appears to be a promising way to improve the connection to the host and the vascularization of grafts, especially when voluminous. Large animal and human studies are necessary to allow clinical translation.

Extensive dental and periodontal defects are frequent and with a limited regenerative potential. Tissue engineering could be a promising tool to obtain personalized oral grafts. However, current research shows a lack of in vitro engineered oral tissues. This is explained by the difficulty to engineer blood vessel systems, impairing the connection to the host tissue and the graft success. Various strategies were used to engineer vascularized tissues and reported successful results, thus needing a clear analysis of the current state of art in oral tissue engineering. This systematic review aimed at studying the critical factors and techniques used to engineer a prevascularized oral tissue graft. PubMed, Cochrane Library, and SCOPUS databases were searched over the last 5 years following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Out of 638 screened studies, 24 were included in the systematic review according to strict inclusion and exclusion criteria and focusing on higher connection to the host vasculature. Animal models were all rodents, and subcutaneous implantation was the most used intervention. Studies presented low-to-unclear risk of bias according to the Systematic Review Center for Laboratory Animal Experimentation tool. Endothelial cells were mainly human umbilical vein endothelial cells, while stromal cells were most of the time oral or mesenchymal stem cells. Coculture of both types of cells at a 1:1 ratio was the most common technique used to obtain vascular networks, and some studies precultured grafts up to 3 weeks to enable network formation before implantation. Prevascularized grafts were produced by various tissue engineering technologies, including cell seeding and/or embedding, cell sheets, and spheroids. All studies reported a statistically significant faster and higher connection to host of prevascularized constructs compared to controls. Vessel networks were indeed denser, with a higher portion of lumen containing erythrocytes and blood flow increased. By assessing the relevant studies on the subject, this systematic review showed that engineered prevascularization proved to be an interesting approach to improve graft connection to the host vasculature and respective specific cell and scaffold criteria. Further studies on enhanced scaffolds and larger animals seem necessary to confirm these promising results with more voluminous grafts and get closer to native human tissues and applications. Autologous oral grafts display limitations in terms of revascularization and morbidity of donor sites, despite being the gold standard. This systematic review aimed at clarifying existing data regarding techniques to engineer prevascularized oral grafts. Tissue engineering techniques, using cocultures of endothelial and oral stromal cells, proved to be an efficient way to enhance and accelerate the connection of the graft to the host vasculature. Engineered prevascularization appears to be a promising way to improve the connection to the host and the vascularization of grafts, especially when voluminous. Large animal and human studies are necessary to allow clinical translation.

L’hyperesthésie dentinaire est une pathologie algique très fréquemment rencontrée en population générale. Elle peut engendrer un inconfort important et pose un certain nombre de difficultés en termes de diagnostic et de prise en charge. La compréhension de ses étiologies est essentielle afin de proposer au patient la solution thérapeutique la plus efficace. Dentine hypersensitivity is a very common pain condition encountered in the general population. It can cause significant discomfort and raises a certain number of difficulties in terms of diagnosis and management. Understanding its etiologies is essential in order to provide the patient most effective therapeutic solution.

IntroductionLa sclérose tubéreuse de Bourneville (STB) est une maladie génétique autosomique dominante rare. Une approche multidisciplinaire est actuellement recommandée pour une meilleure prise en charge globale des patients, en raison des manifestations systémiques de la STB et de leurs complications potentielles.DescriptionL’objectif de notre étude est d’obtenir une description précise de notre cohorte de patients adultes atteints de STB et d’évaluer notre modèle de prise en charge pluridisciplinaire personnalisé.MéthodesL’ensemble des patients atteint d’une STB étaient inclus. L’ensemble de leurs données cliniques, biologiques et radiologiques étaient collectées. Une prise en charge pluridisciplinaire annuelle était réalisée pour ces patients sous forme d’une hospitalisation de jour (HDJ).RésultatsQuatre-vingt-dix patients adultes présentant une STB ont été inclus entre janvier 2000 et septembre 2018. L’âge médian des patients à l’inclusion était de 37 ans (27–47). Quatre-vingt-dix-sept des patients présentaient des lésions cutanées, 89 % des manifestations neurologiques, 83 % des manifestations rénales et 100 % des lésions dentaires avec des puits amélaires. Plus de la moitié des patients avaient des lésions osseuses ostéocondensantes (68 %), des troubles neuropsychiatriques associés à la STB (64 %) et une lymphangioléiomyomatose (59 %). Une approche multidisciplinaire de la STB a été développée, en HDJ avec un suivi personnalisé de l’ensemble des atteintes d’organes permettant un respect des recommandations internationales pour le suivi des patients. L’évaluation de la qualité de vie des patients montre une détérioration de la santé mentale à 47 % mais également physique à 43 %. Les résultats étaient similaires chez leurs aidants. La satisfaction des patients quant à la prise en charge était de 100 % (Fig. 1).ConclusionNous avons obtenu une description précise d’une cohorte de patients adultes atteints de STB ainsi qu’une évaluation de la qualité de vie des patients et des aidants. Notre modèle d’évaluation permet une approche multidisciplinaire et personnalisée des patients avec un haut niveau de satisfaction.