Papillary cystadenoma is a relatively rare salivary gland tumor which has been reported sometimes in association with minor salivary glands.Here, we report a case of papillary cystadenoma of minor salivary gland origin located in the floor of the mouth, in a 59-year-old woman. The patient complained of swelling of the floor of the mouth. During the course of the first medical examination, a circumscribed, elastic hard, movable, dark reddish oval mass was found in the floor of the mouth just by the lower right wisdom tooth, measuring 12×13mm.Clinically an hemangioma was suspected. Under general anesthesia, the lesion was totally excised. Histologically, sections revealed a small and a large cystlike cavities lined with tall, eosinophilic granular epithelial cells disposed in papillary projections filling the lumen. Histopathologically it was diagnosed as a papillary cystadenoma.There was no evidence of recurrence in the patient 7 months after the operation.

The effect of levamisole on DMBA-induced carcinogenesis in the cheek pouch of the hamster was studied. Findings indicate that levamisole modified the response of the pouch to DMBA at six weeks, while this effect was not maintained after 12 weeks of DMBA application.

The effect of autogenous marrow and calcitonin on reactions to a tricalcium phosphate ceramic was studied by subcutaneous implantation in rats. No bone formation was evident in association with uncoated and calcitonin-coated ceramic. At four weeks and thereafter bone formation was evident in association with all marrow-coated implants.

Prostaglandins (PG's) are a group of biologically active acid lipids derived from essential fatty acid 1)recursors. They are widely distributed in the body and most cells aie capable of synthesizing them. PG's have widespread pharmacological effects; they participate in the inflammatory response, and intradermal injection of PGEi* prodLuces vasodilatation and increased vascular perrieability. Some PG's stimutilate resorption of ctulttured fetal rat bone. The inflammatory effects of PG's and their ability to stimulate bone resorption make them potential mediators of inflammation and bone loss in periodontal disease; the PGE, level of inflamed human gingiva is twice that of norimal tissues.

Calcitonin (CT) inhibits bone resorption and initially stimulates bone formation after systemic administration; however, prolonged administration of the hormone inhibits both osteoclastic and osteoblastic activities (RASMUSSEN and BORDIER, The Physiological and Cellular Basis of Metabolic Bone Disease, 1974). Local application of CT has been reported to stimulate bone formation (MANTZAVINOS and LISTGARTEN, J Periodontol 41:663, 1970) and increase the rate of healing at extraction sites (FOSTER and KRONMAN, Oral Surg 38:866, 1974). This is a report on the effect of CT locally applied on connective tissue and on healing of bone defects in rats. It was hypothesized that the hormone may have a bone inductive effect and may enhance the rate of bone healing. Forty adult male Wistar rats were divided into five groups with five experimental and three control rats in each group. Experimental rats had two Ivalon sponges* containing 0.4 MRC units of salmon CT** in a gelatin vehicle implanted under the dorsal skin, and gelfoam surgical sponges$ containing the same amount of CT over surgical defects in the parietal bone and the right tibia. Control rats were similarly treated except that the sponges contained only the gelatin vehicle. Skin injury was produced by two widely spaced horizontal incisions made in the back of each anesthetized rat. Pouches

The pulps of 40 permanent teeth of two monkeys were mechanically exposed and contaminated with adjacent saliva or plaque for 3 to 5 1/2 hours. The pulps were then capped with either Keflin (an antibiotic), Durelon (a polycarboxylate cement), or Dycal (a calcium hydroxide compound). Varnish and then amalgam were inserted. Each monkey received at least one dose of Procion red H-8BS vital dye. The teeth were extracted from one monkey 23 months after capping and from the other monkey 29 months after capping. Serial, decalcified, 7 mum-thick paraffin sections were prepared. Alternate slides were stained with hematoxylin ane eosin. Unstained sections were examined for Procion labeling, and selected slides were stained by the Brown-Brenn method for bacteria. Of 13 teeth capped with Keflin, only 4 responded satisfactorily. All of the Dycal and Durelon-capped pulps were successful at both time intervals. All of the Dycal-capped pulps showed complete bridging and no inflammation or pulp obliteration. Bridging was complete in only three of the Durelon-capped pulps. The findings of this study support the findings in our previous study3 and further substantiate the effectiveness of Dycal as a pulp-capping agent. The often-repeated claim that calcium hydroxide compounds exert a persistent stimulating effect on the pulp resulting in its eventual obliteration was not supported. Durelon is not recommended for pulp capping since the material apparently lacks an antibacterial effect and does not stimulate reparative dentinogenesis at the exposure site. The low rate of satisfactory responses of pulps capped with Keflin, as used, precludes its use of pulp capping.

Mycophenolic acid (MPA) a is a fermentation product of the fungus Penicillium Brevi-Compactutn Dierckx (CLUTERBUCK, Biochem J 27: 654, 1933). When administered systemically, it interferes with the synthesis of guanosine monophosphate, a purine precursor of ribonucleic acid and deoxyribonucleic acid (FRANKLIN, Biochem J 113: 515, 1969). The drug's effectiveness against refractory psoriasis is currently being evaluated and preliminary results indicate that it is effective with minimal side effects (JONES ET AL, 34th Annual Meeting, Society for Investigative Dermatology, NY, 1973). This is a report on the effect of MPA on wound healing. It was postulated that the drug through inhibition of mitosis might retard the healing of skin and oral mucosal wounds. Wound healing was also studied in methotrexate (MTX) b_treated and untreated controls for comparison. A total of 75 young adult male Sprague-Dawley rats were used. The rats were fed a standard chow diet that was ground with a heavy duty Vulcan food mixerc and sifted through a wire screen with an average pore diameter of 1.18 x 1.49 mm. Food consumption was measured daily for each rat for one week to compute the amount of the drug to be mixed with the diet. The rats were then assigned to one of three equal groups. One group of rats received MPA in a maximal dose that can be tolerated by the

A human clinical study was undertaken to evaluate the effectiveness and safety of dexivacaine 2 per cent, mepivacaine 2 per cent, and mepivacaine 3 per cent. A doubleblind technique was used to evaluate time of onset, duration, depth of anesthesia, and side effects. Results indicated no significant differences among the three anesthetics, except that mepivacaine 3 per cent had a significantly longer duration of softtissue symptoms in the mandibular block series. The few side effects noted were minimal and of no statistical significance. The evaluation of an anesthetic by the several parameters employed and especially by the over-all opinion of the anesthesia was deemed a valuable research method when comparing the clinical effectiveness of local anesthetics.

A composite restorative material was subjected to biologic evaluation tests in the teeth of patients, and induced symptoms were correlated with various degrees of inflammatory responses found microscopically. A quartz-filled composite restorative material was subjected to a stringent test in the teeth of patients. The irritational qualities of the material were comparable to those of silicate cement. With judicious use of a protective base, the material should be safe and effective. Certain correlations between pulpal histopathologic responses and the results of clinical tests were found; these should aid the dentist in locating and diagnosing a tooth with pulpitis. A composite restorative material was subjected to biologic evaluation tests in the teeth of patients, and induced symptoms were correlated with various degrees of inflammatory responses found microscopically. A quartz-filled composite restorative material was subjected to a stringent test in the teeth of patients. The irritational qualities of the material were comparable to those of silicate cement. With judicious use of a protective base, the material should be safe and effective. Certain correlations between pulpal histopathologic responses and the results of clinical tests were found; these should aid the dentist in locating and diagnosing a tooth with pulpitis.