Introduction : Prostate cancer (CaP) is common in sub-Saharan Africa, often diagnosed at an advanced stage. The objective of this study was to identify clinical and paraclinical factors predictive of the development of castration resistance in Guinean patients. Material and methods This was a retrospective analytical study conducted in Conakry, Guinea, between January 1, 2019, and December 31, 2023. All patients followed for locally advanced or metastatic hormone-naïve prostate cancer were included. Castration resistance was defined according to the Prostate Cancer Clinical Trials Working Group 3 (PCWG3) criteria. Data were analyzed using univariate and multivariate logistic regression (significance threshold p < 0.05). Results Ninety patients were included. The mean age was 70.48 ± 9.15 years. The median baseline PSA was 221 ng/mL. After a median follow-up of 41.4 months, 46 patients (51.11%) developed castration resistance. In univariate analysis, younger age (p = 0.007), high baseline PSA (p < 0.001), ISUP score ≥ 3 (p < 0.001), number of metastases > 6 (p < 0.001), and time to PSA nadir > 6 months (p < 0.001) were associated with resistance. In multivariate analysis, only an ISUP score ≥ 3 remained an independent predictive factor (ORa = 5.47; 95% CI : 1.84–16.24 ; p = 0.002). Conclusion A high ISUP score is a strong predictor of castration resistance in Guinean men. These results highlight the importance of early histological diagnosis and prognostic stratification.

Urethral diverticulum secondary to incomplete surgical repair represents an even rarer complication. We report the case of a 7-year-old boy presenting with post-void dribbling following partial resection of a supernumerary urethra for Effman type IIA2 urethral duplication. Physical examination revealed a patent ventral meatus and a blind dorsal meatus. Voiding cystourethrography confirmed a residual diverticular cavity communicating with the accessory urethra. Complete surgical excision of the residual supernumerary tract was performed via a perineal approach with satisfactory functional outcomes at 3-month follow-up. This case emphasizes that total excision of the supernumerary urethra is mandatory to prevent diverticulum formation.

The impact of upper urinary tract drainage on survival in patients with cervical cancer complicated by obstructive renal failure remains controversial. The objective of this study was to evaluate the prognostic impact of upper urinary tract drainage on overall survival and the evolution of biological parameters in these patients. Prospective single-center study over 18 months (January 2024-May 2025) including 55 patients presenting with cervical cancer with obstructive renal failure at Conakry University Hospital. Drainage modalities (double-J stent, percutaneous nephrostomy) were analyzed. Outcome criteria included overall survival (Kaplan-Meier), evolution of creatininemia and hemoglobin. Logistic regression and Cox model identified independent prognostic factors. Mean age was 56.3 years. Stage IIIB predominated (65.5

pT1 bladder tumors are considered borderline between NMIBT and MIBT. The aim of this study was to demonstrate the impact of a second resection on the staging, progression, and prognosis of high-grade pT1 bladder tumors. This was a retrospective descriptive and analytical study of 43 patients with high-grade pT1 bladder tumors between 2010 and 2020. We collected 43 patient files with high-grade pT1 bladder tumors. The second resection revealed residual tumors in 72

This study aimed to characterize the typology, analyze the etiological factors, and evaluate the outcomes of surgical management of iatrogenic urogenital fistulas (IUGF). A bicentric descriptive and analytical study with retrospective data collection, including cases of IUGF operated between January 2020 and December 2023 at the Regional Hospital of Labé and the Ignace Deen University Hospital (Guinea). Univariate statistical analyses (Fisher’s exact test) and stratified multivariate analyses were performed to identify significant associations between variables. The dependent variables studied were the type of fistula and the timing of management, while the independent variables included age, etiological factors, symptomatology, and residence. IUGF represented 12.42

Introduction: Urinary lithiasis in children is less common than in adults. Its etiologies are dominated by malformations of the urinary system and hereditary diseases. The objective of this study was to analyze the epidemiological, diagnostic and therapeutic particularities of urinary lithiasis in children in the urology department of the Ignace Deen University Hospital in Conakry. Methodology: This was a descriptive, retrospective, single-center study conducted over a period of 10 years, which concerned children aged 0 to 15 years, operated for urinary lithiasis in the urology department of the Ignace Deen University Hospital in Conakry. Results: Urinary lithiasis in children represented 19.2% of cases of lithiasis operated in the department. The average age of patients was 8.43 ± 5.13 years with extremes of 1 and 15 years. The male predominance was very marked with a sex ratio of 9.3. Dysuria was the most frequent symptom in 90.3% of cases. The stones were mainly located in the lower urinary tract (64.5%) with a predominance of the bladder location. All our patients had benefited from open surgical treatment. The postoperative course was favorable in 51 cases (82.3%), against 11 cases of postoperative complications (17.7%). The average hospital stay was 11.8 ± 4.9 days with extremes of 6 and 32 days. Conclusion: Urinary lithiasis in children represents a significant part of the department's activity. Lower urinary tract lithiasis is the most frequent in our context. Ultrasound and urinary tract without preparation occupy an important place in the diagnostic assessment. Minimally invasive treatment methods for childhood stones remain unavailable in the department.

Introduction : La Dysfonction érectile (DE) est une incapacité persistante ou récurrente à obtenir ou à maintenir une érection suffisamment rigide pour permettre un rapport sexuel satisfaisant. La dysfonction érectile est la dysfonction sexuelle la plus étudiée. Cependant, en raison de la pudeur qui l’entoure dans notre contexte socio culturel, la dysfonction érectile fait l’objet de rares études. Objectif : Cette étude a pour objectif de décrire la dysfonction érectile dans ses aspects épidémiologiques, diagnostiques et thérapeutiques au service d’urologie-andrologie du CHU de Conakry. Méthodologie : Il s’agit d’une étude prospective de type descriptif d’une durée de 06 mois. Elle a porté sur tous les patients reçus et suivis pour DE au service d’urologie-andrologie du CHU de Conakry. Résultats : Il ressort de notre étude que la fréquence de la dysfonction érectile était 8,71%. L’âge moyen était de 46,03 ans avec des extrêmes de 23ans et 75 ans. Dans notre série l’HTA était la comorbidité la plus retrouvée suivie du diabète avec respectivement (n=27)22,88% et (n=16)13,56%. Le tabagisme et l’alcoolisme ont été rapportés respectivement dans 12,71 % et 17,80 %. La Dysfonction érectile a été légère chez 58 patients (49,15%), modérée chez 41 patients (34,75%) et sévère chez 19 patients (16,10%). La prise en charge a consisté en une correction d’habitudes de vie déficiente associée aux traitements pharmacologiques oraux à base d’inhibiteurs de la Phosphodiesterase de type 5 (IPDE5). L’évolution a été favorable chez quarante- neuf patients. Conclusion : La dysfonction érectile est relativement fréquente au service d’urologie-andrologie du CHU de Conakry. Elle est favorisée par les facteurs de risque suivants : l’hypertension artérielle, le diabète, le tabac et l’alcool. La dysfonction érectile légère était la plus fréquente. L’évolution sous traitement oral ( IPDE5) est en général favorable. Mots-clés : Dysfonction érectile, facteurs de risque, IPDE5, CHU Conakry.

Context and Objective: Groin hernia is a common pathology in visceral surgery (2nd rank after appendicitis), which affects approximately 4.6% of the African population. Restoring the normal anatomy of the groin region is one of the most benign interventions. However, uro-andrological complications are possible. This study aimed to contribute to the improvement of the management of urogenital complications of groin hernia surgery. Patients and Method: We carried out a prospective study of descriptive type with a duration of 6 months from 1 August 2021 to 31 January 2022. The data were collected using a pre-established survey sheet. The study covered several sites (public hospitals and private clinics) in Guinea. Results: The urogenital complications of the surgery of the hernia of the groin represented 15.22% or 14 cases out of 92 patients. The average age was 37.00 years with extremes of 20-69 years. Polygamists occupied the first place. The reason for consultation was dominated by decreased testicular volume (42.86%), followed by a desire to conceive (21.43%). Unilateral testicular atrophy represented 63.64%, bilateral 27.27%. We performed a left orchidectomy in one patient and a cystorraphy in another simple operative follow-up. The other cases consisting of testicular atrophy, due to lack of a suitable technical platform, did not benefit from any specific therapeutic treatment. Conclusion: Urogenital complications of groin hernia surgery are relatively common. Testicular atrophy was the main clinical complication. The left orchidectomy and cystorraphy were the therapeutic procedures performed.

Goal: To determine the type of comorbidity and highlight the complications of adenomectomy and comorbidities. Material and Methods: This is a prospective, descriptive, cross-sectional study lasting six (6) months, from July 1, 2022 to December 31, 2022. Patients with BPH on comorbidity condition taken care of during the study period AND have agreed to participate in the study. Results: During our study, 49 cases of benign prostatic hypertrophy with comorbidities were collected, representing a frequency of 29%. The average age ranges for the patients were 43 - 70 years. The age group most affected was 70 to 79 years old (38.80%). Nocturnal urinary frequency was the main reason for consultation present in all our patients. The most frequent comorbidity was hypertension, i.e. 83.70%. The PSA rate between 4 and 10 was the most represented, i.e. 42.86%. The prostate volume was between 61 and 100 ml in 40.82% of patients. Histology showed that it was a benign adenomatous hypertrophy of the prostate in 85.70% and a prostatic adenomyoma in 14.29%. Trans-bladder adenomectomy alone was the most performed technique, i.e. 49%, followed by trans urethral resection of the prostate, i.e. 38.80%. Retention of urine after removal of the catheter was the most observed complication, i.e. 12.20%. Conclusion: Benign prostatic hypertrophy with comorbidities constitutes a frequent association. Because their presence can affect effectiveness and lead to complications.

Objective: Describe the psychosocial aspects of male infertility at the hospital of the Sino-Guinean Friendship. Patients and method: It is a prospective study of a descriptive type covering a period of 6 months. The study covered 17 patients, all received for a desire to conceive after at least one year of regular sexual intercourse without contraception. The data were collected from patient interviews using a pre-established questionnaire. Results: The average age of the patients was 32.07 years with extremes of 23 years and 42 years. During this study, 64.70% of patients were no longer participating in community ceremonies. The patients' relationships with their spouse and family deteriorated in 52.94% and 47.06%, respectively. Conversely, relations with the family of origin remained unchanged in 70.59 percent of cases. The reduction in economic activity was by 13 patients (76.48%). Conclusion: Male infertility causes a real psychic earthquake in men with its corollaries of negative feelings. The rather complex moral repercussions of male infertility affect not only the individual, his/her partner, and family, but also economic activity.

Open AccessEpidemiological, clinical and histopathological characteristics of bladder cancers in Conakry TMO Diallo, MD Bah, MB Bah, A Barry, D Kanté, D Cissé, RL Gnammi, AB Diallo and OR Bah TMO Diallo1 https://orcid.org/0000-0001-8815-5020 , MD Bah1 https://orcid.org/0000-0001-8123-5116 , MB Bah1 , A Barry1 , D Kanté1 , D Cissé1 https://orcid.org/0000-0002-0969-5182 , RL Gnammi1 , AB Diallo1 and OR Bah1 Affiliations 1Urology-andrology department of the Ignace Deen National Hospital in Conakry, Guinea Published Online:1 Mar 2024https://doi.org/10.36303/AUJ.0130https://hdl.handle.net/10520/ejc-mp_afurol_v4_n1_a11SectionsPDF ToolsAdd to favouritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditGMailOutlookCopy LinkMendeley AboutAbstractObjectiveAnalyse the epidemiological, clinical and histopathological characteristics of bladder cancers in Guinean hospitals.Material and methodsWe carried out a descriptive study with retrospective collection, from January 1, 2013 to December 31, 2022, in the Urology Department of the Ignace Deen National Hospital in Conakry. We included all patients with histologically confirmed primary bladder cancer, whose records were found in the hospital archives.Results121 cases of bladder cancer were identified. The mean age of the patients was 58.9 ± 15.5 years, ranging from 17 to 86 years. The M/F sex ratio was 2.02. The risk factors were dominated by tobacco (19.8%), urinary bilharzia (14.9%) and exposure to dyes (5.8%). Hematuria (79.3%) and LUTS (67.8%) were the main reasons for consultation. The most common histological type was urothelial carcinoma in 94 cases (77.7%), followed by squamous cell carcinoma in 26 cases (21.5%).ConclusionThere is an increasing incidence of bladder cancer in our Department. In a difficult health context, primary prevention by combating risk factors constitutes the best public health response to this condition. Previous article FiguresReferencesRelatedDetails Downloaded 0 times InformationCopyright © 2024, the Author(s)LicensesThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.Keywordsbladder cancerold persontobaccohematuriaurothelial carcinomaPDF download Disclosure The authors confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. The authors confirm that they have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, with respect to intellectual property. Ethical conduct of research The authors state that they have obtained appropriate institutional review board outlined in the Declaration of Helsinki for all human or animal experimental investigations. A signed informed consent document has been obtained from all participants included in the study.