Batting performance in cricket constitutes a multidimensional phenomenon influenced by an intricate matrix of biomechanical, physiological, and perceptual-motor elements. This study critically examines the predictive utility of selected anthropometric and motor performance parameters in forecasting composite batting proficiency among Under 16 district-level cricketers. Drawing upon a rigorously screened sample of 100 male athletes, the investigation operationalized ten independent variables encompassing linear body dimensions, muscular strength, explosive power, aerobic endurance, and neurocognitive responsiveness. The analytical framework incorporated descriptive statistics, Pearson product-moment correlations, and stepwise multiple regression modeling to interrogate the data. Descriptive outcomes revealed marked heterogeneity in both motor capabilities and neuromotor speed. Correlation analysis identified a statistically significant inverse association between simple reaction time and batting performance (r = -0.18), signifying that expedited sensorimotor integration may enhance on-field batting efficacy. Multivariate regression further isolated reaction time as the sole significant predictor (â = -0.020, p = .035), while the overall model explained a modest 2.1% of the variance in batting performance (adjusted R² = .021). These empirical findings problematize reductionist paradigms emphasizing isolated physical metrics as determinants of cricketing excellence. Instead, the results underscore the imperative for integrative assessment frameworks incorporating cognitive acuity, technical skill, and situational judgment. In alignment with emergent scholarship in performance optimization and talent development, the study advocates for a paradigm shift toward interdisciplinary diagnostics, recognizing the complex, systemic nature of expertise acquisition in contemporary sport.

Abnormal uterine bleeding (AUB) can occur due to various reasons in females according to their age and most prevalent risk factors. Among them, uterine fibroids are the most common cause of AUB in perimenopausal females. Endometrial actinomycosis is seen sometimes in females with Intrauterine contraceptive devices, but isolated endometrial actinomycosis is very rare, and as per our knowledge, only four cases are reported; among them, two cases are of ovarian actinomycosis, one endometrial actinomycosis in virgin female and one in a postmenopausal female. This case was interesting, as our patient who was perimenopausal and immunocompetent presented with AUB and was diagnosed to have endometrial actinomycosis along with a large leiomyoma.

Background Human microsporidiosis presents as an important and rapidly emerging opportunistic infection. However, the exact burden of this infection especially in the pediatric population of Northern India remains unknown. In this study, we investigated the prevalence of microsporidia among human immunodeficiency virus (HIV)-positive and HIV-negative pediatric patients who presented with diarrhea. Methods A total of 263 children were recruited consisting of 98 HIV seropositive with diarrhea and 165 HIV seronegative but with diarrhea. Morning stool samples were collected and both direct and formol ether concentrated samples were examined for the presence of intestinal parasites. The modified acid-fast staining was done for coccidian parasites and trichrome stain for microsporidia detection. Further, the species were detected using a real-time polymerase chain reaction (PCR) targeting a conserved region of the small ribosomal subunit rRNA gene of Enterocytozoon bieneusi, Encephalitozoon hellem, Encephalitozoon intestinalis, and Encephalitozoon cuniculi. Results Overall, one or more parasites were detected in 52.04% (51/98) of HIV seropositive and 53.33% (88/165) of seronegative children (p = 0.8391). However, coccidian parasites were detected in a significantly huge number of HIV seropositive children (21.43% [21/98]) as compared with HIV seronegative children (4.24% [7/165]). Microsporidial DNA could be detected in HIV seropositive with diarrhea children (17.35% [17/98]) by PCR. A significant correlation between low CD4 count (≤ 200/μL) and intestinal parasite positivity could be established. Conclusion Microsporidia is a significant cause of diarrhea in HIV seropositive pediatric patients and should be kept in mind as one of the differential diagnoses in such patients.

Abstract Introduction  Intestinal parasitic infections continue to loom in developing countries with low sanitation and socioeconomic conditions. Pandemic times are especially important to study the prevalence of these pathogens since the focus of all healthcare services was coronavirus disease 2019 (COVID-19). This study aimed to evaluate the prevalence and time-trend of intestinal parasitic infections in the capital region of India during the pandemic times. Methods  In this cross-sectional study, a retrospective review based on data from the past 2 years in the post-COVID-19 pandemic was used. Descriptive and time-trend analyses were applied to the data. Time series analysis was analyzed using the best fit autoregressive integrated moving average (ARIMA) model to look for seasonality in trends and forecasting. Results  A total of 7267 patients' stool samples over a 2-year pandemic period were included in the study. Intestinal parasites were detected in 11.18% (813/7276) patients. Giardia lamblia (2.28%) and Blastocystis hominis (3.78%) were the predominant ones. Time-trend analysis from 2020 to 2021 using ARIMA model predicted an increasing trend with waning of pandemic. The most prevalent infection was found in the monsoon and autumn months. Conclusion  Rates of infection with Giardia lamblia and Blastocystis hominis have increased in comparison to other protozoan infections like Entamoeba histolytica when compared with prepandemic hospital-based studies. With fading of the pandemic, further increasing trends are predicted.

Enteric microbial agents in HIV differ in several ways between developing and developed world, the awareness of which can often guide appropriate prevention and patient treatment when limitation of resources prevent laboratory diagnosis of exact etiological agent. The primary objective of this study was to define and compare enteric bacterial pathogens in HIV-1 infected with diarrheal symptoms and non-HIV infected controls with diarrheal symptoms at a tertiary care hospital in northern India. This prospective study was conducted between January 2014 and December 2015 of a tertiary care academic health organization of North India. Stool samples from 300 HIV seropositive cases with diarrhea (study group) and 600 HIV negative diarrhea cases (control group) were examined. Samples were inoculated onto standard culture media. All the isolates were tested for antimicrobial susceptibility. Out of 300 HIV seropositive cases with diarrhea, 114 (38%) were positive for bacterial pathogens whereas in 600 HIV seronegative with diarrhea controls 120 (20%) were positive for bacterial pathogens. 41 isolates of Diarrheagenic Escherichia coli, 24 Campylobacter jejuni, 10 Aeromonas hydrophilia, 16 Shigella spp., 9 Salmonella spp., and 14 Yersinia enterocolitica were recovered from the HIV infected cases. Most of the bacteria were resistant to nalidixic acid. There is underline need for epidemiological investigations to screen microbial etiological agents in HIV infected subjects with diarrhoea along with their antibiogram periodically for reduction of morbidity and mortality in these patients.

AIMS AND OBJECTIVES:The aim and objective of this study was to assess the temporal changes in the microbiological profiles and antimicrobial resistance patterns of uropathogens in pediatric community-acquired UTI.MATERIALS AND METHODS:This is a retrospective analysis of data collected over a Scattered period of 5 years. The baseline data collected were from January to December 2009, and the second period considered for comparison was from January to December 2014. Urine specimens from children (<17 years) suspected of UTI were cultured by a semi-quantitative method on cysteine lactose electrolyte-deficient medium. Antibiotic sensitivity was put up by Kirby-Bauer disc diffusion method as per the Clinical and Laboratory Standard Institute guidelines.RESULTS:In the year 2009, 340 of 2104 (16.15%) urine specimens yielded significant colony count, whereas in 2014, it was 407 of 2212 (18.39%) (P = 0.051). Escherichia coli was the predominant pathogen and was significantly more prevalent in girls than in boys (P < 0.0001) during both periods. There was a significant overall increase in resistance to ampicillin (from 40.29% to 58.72%), amoxyclav (from 26.17% to 40.54%), nitrofurantoin (from 28.82% to 39.06%), and norfloxacin (from 30% to 41.42%). However, the maximum increase in the resistance was noted for co-trimoxazole from 35.58% in 2009 to 63.39% in 2014 (P = 0.0000058). The prevalence of extended-spectrum beta-lactamases (ESBLs) has also significantly increased from 21.7% to 33.16% (P = 0.0045).CONCLUSION:Although E. coli remains the prime pathogen in pediatric UTI, the prevalence of resistance has dramatically increased over the 5-year study period. Our study highlights the emergence of community-acquired ESBL-producing uropathogens in children proclaiming treatment challenges.

BACKGROUND:Diarrhoea is an important cause of both morbidity and mortality among children in India. Coccidian parasitic infections are an important cause of diarrhea in immunocompromised patients, but their investigations are rarely sought by the treating physicians in seemingly immunocompetent children. This study was aimed to find the incidence rate of coccidian parasites in all children presented with diarrhoea, irrespective of their immune status.MATERIALS AND METHODS:Between December 2015 and May 2016, all fecal samples from children aged between 0 and 15 years presenting with diarrhoea, irrespective of their immune status, were examined using conventional wet mount and modified acid-fast staining. At the end of the study, records of their clinical history and immune status including HIV positivity were evaluated. Findings of wet-mount and modified acid-fast stained smear microscopy were analyzed in relation with clinical details.RESULTS:During the study, samples from 200 children (single sample) with diarrhea were processed. Their mean age was 5.7 ± 3.3 years (range 4-168 months). Seventeen out of 200 (8.5%) samples were positive for acid-fast coccidian parasites. Eight (4%) samples were found to be positive for Cryptosporidium hominis, while 5 (2.5%) were positive for Cyclospora cayetonensis and 4 (2%) samples for Isospora belli oocysts. Half (50%) of the children who were tested positive for Cryptosporidium and Cyclospora were found to be otherwise immunocompetent. However, all four cases of Isosporiasis were immunocompromised patients.CONCLUSION:We highlight the high incidence of coccidian parasites among immunocompetent children with diarrhea. The clinicians need to be aware that coccidian parasites are a potential cause of childhood diarrhea even in immunocompetent children.

Almost one-fourth of the world's population is possibly suffering from parasitic diseases. Children are more vulnerable to various parasitic infections as compared with normal adults due to their outdoor activities, immature immune system, nonadherence to good hygiene practices, and preference for street food. Parasitic infections are known to put a grave strain on their physical and cognitive growth and development. Thus, awareness and importance of pediatric parasitology need escalated recognition among pediatricians. Parasitic diseases both common and uncommon that are encountered in Indian children are contemplated in this review. We have covered epidemiology, life cycle, clinical features, and diagnosis of pediatric parasitic infections that transpire in India, including some preventive strategies.

ABSTRACT Introduction: Occupational hazards such as accidental exposure to sharp, cuts, and splashes are common among health-care workers (HCWs). Aims and Objectives: To determine the occurrence of self-reported occupational exposures to these hazards and to know the prevalent practices following the exposure. The second aim was to know the baseline antibody levels against hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) immediately after these accidents. Methods: An observational prospective study was done in the HCWs of a tertiary care academic health organization of North India from January 2011 to December 2013. At the time of self-reporting of injury, a questionnaire was administered. Blood sample of HCWs and of the source, if identified, was collected for baseline HBV, HCV, and HIV serum markers. The exposed HCWs were followed up and repeat testing was done after 3–4 weeks for seroconversion up to 6 months. Results: A total of 476 injuries were reported. Needlestick injury of fingers was the most common. Doctors were found to have the highest exposure rate (73.7%) distantly followed by nurses (19.1%). A significant number of the HCWs (125, 26.3%) vaccinated in past had hepatitis B surface antibody (anti-HBs) titers ≥10 mIU/mL (protection defined as anti-HBs level ≥10 mIU/ml). Only 44 sources were found to be seropositive (11 for HIV, 9 for HCV, and 24 for HBV). No seroconversion was seen in any of the exposed HCWs after 6 months. Conclusions: The incidence of needlestick and sharp injuries is most often encountered in emergency wards. Anti-HBs titers were suboptimal in many of the HCWs requiring a booster dose of HBV vaccination.

Background: Urinary tract infections (UTIs) remain a major problem both in hospitalized and outdoor patients. Multidrug-resistant enterococci are emerging as a major nosocomial pathogen with increasing frequency. However, the incidence of community-acquired enterococcal infections and species prevalent in India is not thoroughly investigated. Objectives: This study aims to estimate the burden of community-acquired UTIs seen at a tertiary care hospital and to identify the Enterococcus species isolated from these patients. The study also aims to determine the antibiotic susceptibility pattern with reference to high-level aminoglycosides and vancomycin. Materials and Methods: Semi-quantitative cultures from a total of 22,810 urine samples obtained from patients seen at various Outpatient Departments were analyzed. From them 115 nonduplicate isolates of enterococci were obtained as significant pure growth (>105 cfu/ml) and speciated. Antibiotic susceptibility was performed by Kirby–Bauer disc diffusion method. Vancomycin resistance screening was performed by the vancomycin screen agar method recommended by Clinical and Laboratory Standards Institute and confirmed by determination of minimum inhibitory concentration by agar dilution method. Results: Of 115 enterococcal isolates, 61 were identified as Enterococcus faecalis, 42 as Enterococcus faecium, 3 each as Enterococcus dispar, and Enterococcus pseudoavium. High-level gentamicin resistance (HLGR) was higher in E. faecium (47.6%) than E. faecalis (32.7%) and HLSR also showed the same pattern with 47.6% and 27.9% resistance, respectively. Vancomycin resistant enterococci accounted for 11.3% of the isolates, and out of them 53.8% were E. faecium by agar dilution method. Conclusion: High rate of resistance to antibiotics of penicillin group and aminoglycosides was observed in our tertiary care hospital even in community acquired UTIs. Hence, there is an urgent need for more rational and restricted use of antimicrobials.

Introduction: HIV infection represents a major public health problem for both developing and developed countries as it has grown to global pandemic. Spectrum of clinical presentation of HIV can greatly vary with geopolitical, socioeconomic and cultural environment. Aims: The aim of this study was to estimate the prevalence, socio-demographic conditions, clinical presentations, opportunistic infections and the possible associated risk factors for acquiring HIV infection. Materials and Methods: An observational prospective study was conducted from January 2010 to December 2014 at our centre situated in north India. As per the strategy and policy prescribed by NACO, tests were performed on the serum samples. Results: Out of the total 35369 clients tested for HIV infection, 292 were found to be HIV-1 seropositive. Two HIV-2 cases were found among the studied population. The seroprevalence of HIV was found to be 0.83% (294/35369). Mean age of the study group was 30 ± 5.65 (range: 02 - 80) years. Overall positivity rates among attendees were found to be 0.97% (138/14098), 0.96% (35/3610), 0.82% (7/850), 0.78% (22/2810) and 0.65% (92/14001) in the years 2010, 2011, 2012, 2013 and 2014 respectively. Heterosexual route of transmission was the major route of infection in 78.2 % patients. At the time of presentation, it was observed that Tuberculosis (14.9%) was the most common opportunistic infection. Conclusion: The study shows that there is a decreasing trend in the HIV prevalence in North India. However, the number of HIV cases is still significant and suggests the need for focused prevention efforts in high-risk groups.

The 2014–2015 Ebola epidemic is the largest in history, affecting multiple countries in West Africa. In late July 2014, the World Health Organization (WHO) declared the outbreak a Grade 3 emergency, its highest level of any emergency response. In early August, they declared it a public health emergency of international concern, meaning it is a serious public health event that endangers international public health. Indeed, by the end of September 2014, the United Nations stated the outbreak is “a threat to international peace and security.” Guinea located on the Atlantic coast of West Africa, is the first country in this geographical region in which an outbreak of Ebola virus disease has occurred. Cases having been confirmed in other countries include Guinea, Liberia, and Sierra Leone. There were a small number of cases reported in Nigeria and Mali and a single case reported in Senegal; however, these cases were contained with no further spread in these countries. Confirmed imported cases have occurred in the United States, Italy, Spain, and the United Kingdom. The WHO declared the end of the Ebola outbreak in Liberia on May 9, 2015 but on June 29, routine surveillance again detected a new confirmed case of Ebola in Liberia. On November 18, 2014, India has quarantined a man who was cured of Ebola in Liberia. As of August 21, 2015, the cumulative number of probable, suspected, and laboratory-confirmed cases attributed to Ebola virus (EBOV) is 28,036, including 11,301 deaths. Zaire EBOV strain has been identified as causative agent for 2014 Ebola epidemic.