To implant deep brain stimulation (DBS) electrodes in the porcine pontine micturition centre (PMC) in order to establish a large animal model of PMC-DBS.
Background: A new intracerebral microinjection instrument (IMI) allowing multiple electrophysiologically guided microvolume injections from a single proximal injection path in rats has been adapted to clinical use by coupling the IMI to an FHC microTargeting Manual Drive, designed to be used with standard stereotactic frame-based systems and FHC frameless microTargeting Platforms. Methods: The function and safety of the device was tested by conducting bilateral electrophysiologically guided microinjections of fluorescent microspheres in the substantia nigra of 4 Göttingen minipigs. Results: The device was easy to handle and enabled accurate electrophysiologically guided targeting of the substantia nigra with minimal local tissue damage. Conclusion: The IMI is suitable for clinical use and may prove useful for various stereotactic procedures that require high levels of precision and/or three-dimensional distribution of therapeutics within the brain.
Carsten R. Bjarkam合作论文数4Lise M Fitting合作论文数3Mette S. Nielsen合作论文数3Miles G. Cunningham合作论文数3Karl Reinhart合作论文数3
Andreas N Glud合作论文数Institute of Anatomy, Aarhus University3
Jens Christian Hedemann Sørensen合作论文数Department of Neurosurgery, Aarhus University;Department of Clinical Medicine, Aarhus University;Inst, of Clinical Medicine, Aahus Universitets Hospital3Lauren E. Schrock合作论文数2
Philip A. Starr合作论文数Department of Neurosurgery, University of California, San Francisco2Margolin Lee合作论文数2Keller Jiří合作论文数2Roberts David W合作论文数2
Hana Malikova合作论文数Third Medical Faculty, Charles University in Prague2Miroslav Kalina合作论文数2Tomas Prochazka合作论文数2
Nicole Brennan合作论文数2Peter Lindvall合作论文数2
Zdenek Vojtech合作论文数2Vilibald Vladyka合作论文数2
Eric C. Leuthardt合作论文数Department of Neurological Surgery, Washington University School of Medicine in St. Louis;Division of Neurotechnology, Washington University School of Medicine in St. Louis;Barnes-Jewish Hospital;St. Louis Children’s Hospital2
Pablo A. Valdes合作论文数2
Michael Blomquist合作论文数1
Mahesh B Shenai合作论文数1Rasmus Langelund Jørgensen合作论文数1brent t harris合作论文数1Josef Vymazal合作论文数1
Nick Anderson合作论文数1
Kaare Meier合作论文数1
Tommy Bergenheim合作论文数Department of Clinical Sciences, Umeå University;Department of Pharmacology and Clinical Neuroscience, Umeå University1
Breshears Jonathan D合作论文数Dept Neurol Surg, Univ Calif San Francisco1Philip H. Gutin合作论文数Mem Sloan Kettering Canc Ctr1Kåre S. Ettrup合作论文数1Leif Østergaard合作论文数1
Arne Møller合作论文数Department of Clinical Medicine, Aarhus University1Roman Liscak合作论文数Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital1Iva Mareckova合作论文数1Graham A. Glass合作论文数1Xiaoyao Fan合作论文数1Stephanie Guthrie合作论文数1
Aage Kristian Olsen Alstrup合作论文数Department of Clinical Medicine, Aarhus University1V Dbaly合作论文数1
Harrison C Walker合作论文数1
Connie Y. Chang合作论文数Johns Hopkins University1Jill L. Ostrem合作论文数1
Chadwick Christine合作论文数School of Medicine, University of California, San Francisco1Ronald B. Franklin合作论文数1Frederikke Rosendal合作论文数1Bob L. Hou合作论文数1Kristian Nørholm Jensen合作论文数1
