PURPOSE:We assessed the performance of the ImmunoCyt immunocytochemical test for detecting bladder cancer recurrence in patients with prior superficial bladder cancers compared with cystoscopic and histological findings.MATERIALS AND METHODS:A total of 341 patients with a history of bladder cancer undergoing monitoring were evaluated at 4 sites. The results of cytology and/or ImmunoCyt were analyzed for sensitivity and specificity compared with biopsy confirmed cancer.RESULTS:The overall sensitivity of cytology alone, ImmunoCyt alone and the 2 methods combined was 23%, 81% and 81%, respectively. The specificity of cytology alone, ImmunoCyt alone and of the 2 methods combined was 93%, 75% and 73%, respectively. The immunocytochemical test was more sensitive than cytology for detecting grades 1 and 2, and stages Ta, T1, and T2 urothelial carcinoma, and it was equally sensitive for detecting grade 3 cancers and carcinoma in situ (CIS). The sensitivity of the combined tests for grades 1 to 3/CIS was 79%, 90% and 82%, while for stages Ta, T1, T2+ and CIS it was 83%, 75%, 100% and 100%, respectively. The overall positive and negative predictive values of the combined tests were 37% and 95%, respectively. Importantly the immunocytochemical test could detect 71% of small (less than 1 cm) tumors.CONCLUSIONS:ImmunoCyt is a sensitive test for detecting bladder cancer. Because of its high sensitivity for detecting small tumors, even those of low histological grade, and its high negative predictive value, this test may have a role in decreasing the frequency of cystoscopic examinations for monitoring patients with low risk bladder cancer.

You have accessJournal of UrologyDiscussed Poster, Sunday, May 9, 2004, 8:00 am - 12:00 pm1 Apr 2004284: Monitoring Superficial Bladder Cancer (BC) with the Immunocyt Fluorescent Cytology Test Edward M. Messing, Howard Korman, Edward Barker, Jeanne Underhill, Lisa Teot, and David Bostwick Edward M. MessingEdward M. Messing More articles by this author , Howard KormanHoward Korman More articles by this author , Edward BarkerEdward Barker More articles by this author , Jeanne UnderhillJeanne Underhill More articles by this author , Lisa TeotLisa Teot More articles by this author , and David BostwickDavid Bostwick More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37546-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "284: Monitoring Superficial Bladder Cancer (BC) with the Immunocyt Fluorescent Cytology Test." The Journal of Urology, 171(4S), pp. 74–75 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 74-75 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Edward M. Messing More articles by this author Howard Korman More articles by this author Edward Barker More articles by this author Jeanne Underhill More articles by this author Lisa Teot More articles by this author David Bostwick More articles by this author Expand All Advertisement Loading ...