A study of benzodiazepine receptor affinity and anticonvulsant activity of new thiazolo[4, 3-c] and pyrrolo[2, 1-c][1, 4]benzodiazepines in mice is described. Among this series, a tetracyclic triazolo compound exhibits a good affinity for benzodiazepine receptor (Ki = 0.243 μM) correlated with low toxicity and anticonvulsant activity in mice.

Synthesis of new 3-alkyl-6-arylhexahydropyrimidine-2,4-dione derivatives was achieved starting from various benzaldehydes. Their affinity towards the benzodiazepine receptor and their anticonvulsant effect were evaluated.