Background: The incidence of cutaneous melanoma is increasing in Italy, in parallel with the implementation of gene panels. Therefore, a revision of national genetic assessment criteria for hereditary melanoma may be needed. The aim of this study was to identify predictors of susceptibility variants in the largest prospective cohort of Italian high-risk melanoma cases studied to date. Materials and methods: From 25 Italian centers, we recruited 1044 family members and germline sequenced 940 cutaneous melanoma index cases through a shared gene panel, which included the following genes: CDKN2A, CDK4, BAP1, POT1, ACD, TERF2IP, MITF and ATM. We assessed detection rate according to familial status, region of origin, number of melanomas and presence and type of non-melanoma tumors. Results: The overall detection rate was 9.47% (5.53% analyzing CDKN2A alone), ranging from 5.14% in sporadic multiple melanoma cases (spoMPM) with two cutaneous melanomas to 13.9% in familial cases with at least three affected members. Three or more cutaneous melanomas in spoMPM cases, pancreatic cancer and region of origin predicted germline status [odds ratio (OR) = 3.23, 3.15, 2.43, P < 0.05]. Conversely, age > 60 years was a negative independent predictor (OR = 0.13, P = 0.008), and was the age category with the lowest detection rate, especially for CDKN2A. Detection rate was 19% when cutaneous melanoma and pancreatic cancer clustered together. Conclusions: Gene panel doubled the detection rate given by CDKN2A alone. National genetic testing criteria may need a revision, especially regarding age cut-off (60) in the absence of strong family history, pancreatic cancer and/or a high number of cutaneous melanomas.

Apocrine adenocarcinoma (AA) of the axilla is an uncommon adnexal neoplasm, typically manifesting as a slow-growing, solitary nodule or multinodular mass, with variable ulceration or hemorrhage. Available evidence concerning this clinicopathological entity is limited to individual case reports and small case series, often lacking dermoscopic description.

Since SARS-COV-2 pandemic began, frontline healthcare workers demonstrated to develop facial dermatoses, such as acne, rosacea and seborrheic dermatitis, secondary to prolonged use of personal protective equipment (PPE).

Journal of the European Academy of Dermatology and VenereologyVolume 33, Issue 2 p. e84-e87 Letter to the Editor Comparison of clinical and ultrasound scores in patients with hidradenitis suppurativa: results from an Italian ultrasound working group M. Napolitano, Corresponding Author M. Napolitano maddy.napolitano@gmail.com Department of Medicine and Health Sciences, Vincenzo Tiberio, University of Molise, Campobasso, ItalyCorrespondence: M. Napolitano. E-mail: maddy.napolitano@gmail.comSearch for more papers by this authorP.G. Calzavara-Pinton, P.G. Calzavara-Pinton Department of Dermatology, University of Brescia, Brescia, ItalySearch for more papers by this authorA. Zanca, A. Zanca Department of Dermatology, University of Brescia, Brescia, ItalySearch for more papers by this authorL. Bianchi, L. Bianchi Department of Dermatology, University of Rome Tor Vergata, Rome, ItalySearch for more papers by this authorR.D. Caposiena Caro, R.D. Caposiena Caro Department of Dermatology, University of Rome Tor Vergata, Rome, ItalySearch for more papers by this authorA.M. Offidani, A.M. Offidani Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, ItalySearch for more papers by this authorG. Ganzetti, G. Ganzetti Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, ItalySearch for more papers by this authorE. Molinelli, E. Molinelli Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, ItalySearch for more papers by this authorV. Dini, V. Dini Department of Dermatology, University of Pisa, Pisa, ItalySearch for more papers by this authorT. Oranges, T. Oranges Department of Dermatology, University of Pisa, Pisa, ItalySearch for more papers by this authorM. Romanelli, M. Romanelli Department of Dermatology, University of Pisa, Pisa, ItalySearch for more papers by this authorC.G. Egan, C.G. Egan CE Medical Writing, Pisa, ItalySearch for more papers by this authorG. Fabbrocini, G. Fabbrocini Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalySearch for more papers by this authorG. Monfrecola, G. Monfrecola Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalySearch for more papers by this authorF. Lacarrubba, F. Lacarrubba Dermatology Clinic, University of Catania, Catania, ItalySearch for more papers by this authorM.L. Musumeci, M.L. Musumeci Dermatology Clinic, University of Catania, Catania, ItalySearch for more papers by this authorE. Passoni, E. Passoni Unit of Dermatology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy Department of Medical and Surgical Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalySearch for more papers by this authorM. Venturini, M. Venturini Department of Dermatology, University of Brescia, Brescia, ItalySearch for more papers by this authorG. Micali, G. Micali Dermatology Clinic, University of Catania, Catania, ItalySearch for more papers by this author M. Napolitano, Corresponding Author M. Napolitano maddy.napolitano@gmail.com Department of Medicine and Health Sciences, Vincenzo Tiberio, University of Molise, Campobasso, ItalyCorrespondence: M. Napolitano. E-mail: maddy.napolitano@gmail.comSearch for more papers by this authorP.G. Calzavara-Pinton, P.G. Calzavara-Pinton Department of Dermatology, University of Brescia, Brescia, ItalySearch for more papers by this authorA. Zanca, A. Zanca Department of Dermatology, University of Brescia, Brescia, ItalySearch for more papers by this authorL. Bianchi, L. Bianchi Department of Dermatology, University of Rome Tor Vergata, Rome, ItalySearch for more papers by this authorR.D. Caposiena Caro, R.D. Caposiena Caro Department of Dermatology, University of Rome Tor Vergata, Rome, ItalySearch for more papers by this authorA.M. Offidani, A.M. Offidani Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, ItalySearch for more papers by this authorG. Ganzetti, G. Ganzetti Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, ItalySearch for more papers by this authorE. Molinelli, E. Molinelli Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, ItalySearch for more papers by this authorV. Dini, V. Dini Department of Dermatology, University of Pisa, Pisa, ItalySearch for more papers by this authorT. Oranges, T. Oranges Department of Dermatology, University of Pisa, Pisa, ItalySearch for more papers by this authorM. Romanelli, M. Romanelli Department of Dermatology, University of Pisa, Pisa, ItalySearch for more papers by this authorC.G. Egan, C.G. Egan CE Medical Writing, Pisa, ItalySearch for more papers by this authorG. Fabbrocini, G. Fabbrocini Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalySearch for more papers by this authorG. Monfrecola, G. Monfrecola Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, ItalySearch for more papers by this authorF. Lacarrubba, F. Lacarrubba Dermatology Clinic, University of Catania, Catania, ItalySearch for more papers by this authorM.L. Musumeci, M.L. Musumeci Dermatology Clinic, University of Catania, Catania, ItalySearch for more papers by this authorE. Passoni, E. Passoni Unit of Dermatology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy Department of Medical and Surgical Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalySearch for more papers by this authorM. Venturini, M. Venturini Department of Dermatology, University of Brescia, Brescia, ItalySearch for more papers by this authorG. Micali, G. Micali Dermatology Clinic, University of Catania, Catania, ItalySearch for more papers by this author First published: 03 September 2018 https://doi.org/10.1111/jdv.15235Citations: 21Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume33, Issue2February 2019Pages e84-e87 RelatedInformation

Journal of the European Academy of Dermatology and VenereologyVolume 33, Issue 5 p. e195-e198 Letter to the Editor Multisystem non-arthropathic reticulohistiocytosis: problems and pitfalls in the differential diagnosis of multisystem non-Langerhans-cell histiocytoses A. Bonometti, Corresponding Author A. Bonometti arturo.bonometti11@gmail.com Unit of Anatomic Pathology, Department of Molecular Medicine, IRCCS San Matteo Foundation, University of Pavia, Via Forlanini 14, 27100 Pavia, ItalyCorrespondence: A. Bonometti. E-mail: arturo.bonometti11@gmail.comSearch for more papers by this authorG. Sacco, G. Sacco Unit of Dermatology, University of Padua, Via Gallucci, 4, 35121 Padua, ItalySearch for more papers by this authorE. De Juli, E. De Juli Division of Pneumology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162 Milan, ItalySearch for more papers by this authorR. Invernizzi, R. Invernizzi Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 16, 27100 Pavia, ItalySearch for more papers by this authorL. Venegoni, L. Venegoni Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, 20122 Milan, ItalySearch for more papers by this authorF. Bagnoli, F. Bagnoli Department of Oncology and Hematology, University of Milan, Via Festa del Perdono, 7, 20122 Milan, ItalySearch for more papers by this authorC. Moltrasio, C. Moltrasio Unit of Dermatology, IRCCS Ca’ Granda - Maggiore Policlinico Hospital Foundation Milan, University of Milan, Via Pace, 9, 20122 Milan, ItalySearch for more papers by this authorE. Passoni, E. Passoni Unit of Dermatology, IRCCS Ca’ Granda - Maggiore Policlinico Hospital Foundation Milan, University of Milan, Via Pace, 9, 20122 Milan, ItalySearch for more papers by this authorF. Bellistri, F. Bellistri Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 16, 27100 Pavia, ItalySearch for more papers by this authorP. Bianchi, P. Bianchi Department of Oncohematology, Anemia Pathophysiology Section, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore di Milano, Via Mangiagalli 32, Milan, ItalySearch for more papers by this authorM. Alaibac, M. Alaibac Unit of Dermatology, University of Padua, Via Gallucci, 4, 35121 Padua, ItalySearch for more papers by this authorM. Paulli, M. Paulli Unit of Anatomic Pathology, Department of Molecular Medicine, IRCCS San Matteo Foundation, University of Pavia, Via Forlanini 14, 27100 Pavia, ItalySearch for more papers by this authorE. Berti, E. Berti Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, 20122 Milan, Italy Department of Oncology and Hematology, University of Milan, Via Festa del Perdono, 7, 20122 Milan, ItalySearch for more papers by this author A. Bonometti, Corresponding Author A. Bonometti arturo.bonometti11@gmail.com Unit of Anatomic Pathology, Department of Molecular Medicine, IRCCS San Matteo Foundation, University of Pavia, Via Forlanini 14, 27100 Pavia, ItalyCorrespondence: A. Bonometti. E-mail: arturo.bonometti11@gmail.comSearch for more papers by this authorG. Sacco, G. Sacco Unit of Dermatology, University of Padua, Via Gallucci, 4, 35121 Padua, ItalySearch for more papers by this authorE. De Juli, E. De Juli Division of Pneumology, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162 Milan, ItalySearch for more papers by this authorR. Invernizzi, R. Invernizzi Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 16, 27100 Pavia, ItalySearch for more papers by this authorL. Venegoni, L. Venegoni Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, 20122 Milan, ItalySearch for more papers by this authorF. Bagnoli, F. Bagnoli Department of Oncology and Hematology, University of Milan, Via Festa del Perdono, 7, 20122 Milan, ItalySearch for more papers by this authorC. Moltrasio, C. Moltrasio Unit of Dermatology, IRCCS Ca’ Granda - Maggiore Policlinico Hospital Foundation Milan, University of Milan, Via Pace, 9, 20122 Milan, ItalySearch for more papers by this authorE. Passoni, E. Passoni Unit of Dermatology, IRCCS Ca’ Granda - Maggiore Policlinico Hospital Foundation Milan, University of Milan, Via Pace, 9, 20122 Milan, ItalySearch for more papers by this authorF. Bellistri, F. Bellistri Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 16, 27100 Pavia, ItalySearch for more papers by this authorP. Bianchi, P. Bianchi Department of Oncohematology, Anemia Pathophysiology Section, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore di Milano, Via Mangiagalli 32, Milan, ItalySearch for more papers by this authorM. Alaibac, M. Alaibac Unit of Dermatology, University of Padua, Via Gallucci, 4, 35121 Padua, ItalySearch for more papers by this authorM. Paulli, M. Paulli Unit of Anatomic Pathology, Department of Molecular Medicine, IRCCS San Matteo Foundation, University of Pavia, Via Forlanini 14, 27100 Pavia, ItalySearch for more papers by this authorE. Berti, E. Berti Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Via Pace, 9, 20122 Milan, Italy Department of Oncology and Hematology, University of Milan, Via Festa del Perdono, 7, 20122 Milan, ItalySearch for more papers by this author First published: 01 February 2019 https://doi.org/10.1111/jdv.15461Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume33, Issue5May 2019Pages e195-e198 RelatedInformation

Background Ultrasound (US) is a real-time non-invasive technique that has been demonstrated to support an early diagnosis and a more precise assessment of hidradenitis suppurativa (HS). Objectives To compare the clinical and US evaluation of a series of HS patients. Methods 434 HS patients (259 F, 175 M; mean age 33.82 +/- 13.31 years) observed across 19 Italian dermatology centres [members of the Italian Ultrasound Working Group (IUWG)] were enrolled in a retrospective study. Clinical staging was obtained by the Hidradenitis Suppurativa Physician's Global Assessment score (HS-PGA), while the ultrasonographic staging was determined by the US HS-PGA, based on the same scores as clinical HS-PGA but performed with the aid of US. Results At the end of the study, the mean clinical and US HS-PGA scores were 2.70 and 2.92, respectively. Direct comparison of clinical and ultrasonographic assessment revealed that a higher proportion of patients was classified as having moderate and very severe disease by US. In particular, 117 patients (26.96%) had a worse classification by US HS-PGA compared to clinical assessment. Conclusion Our findings confirm that the use of clinical grading only to assess HS severity may underestimate the real disease severity. US examination can be considered an essential non-invasive imaging tool available to dermatologists for a more accurate diagnosis, staging, treatment planning and monitoring of HS and should be included in the pathway to an optimal standard of care of HS.

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The clinical characteristics associated with hidradenitis suppurativa (HS) severity are poorly understood. In this study, 124 patients with HS from 6 Italian dermatology centres participated in this study. Disease severity was assessed using the Hidradenitis Suppurativa Physician's Global Assessment score (HS-PGA) and Hurley score. The impact of clinical characteristics on disease severity was assessed by logistic regression. Clinical characteristics were similar between men (n = 53) and women (n = 71). Disease severity was also similar; 75% of the patients had Hurley stage II or III disease, and > 60% had moderate, severe or very severe HS as judged by HS-PGA. Lesions were more frequent in the gluteal region in men (32.3% in men vs. 8.7% in women, P < 0.001) and more frequent on the breast in women (16.3% in women vs. 4.6% in men, P = 0.02). Obesity was associated with increased disease severity as measured by HS-PGA (OR: 3.28, 95% CI 1.55-6.95, P < 0.01) and Hurley classification (OR: 3.22, 95% CI 1.34-7.31, P < 0.01). Although severity of HS is similar between the sexes, the localization of lesions is different.

EDITOR, A 7yearold boy was admitted to our Dermatology Unit because of some nodular lesions located on the scalp. The patient came from Brazil and was in Italy for summer vacation. His mother observed the appearance of 4 nodular lesions 2 weeks earlier, when both of them were in Brazil. The child was in good general health. No systemic symptoms were reported. General physical examination did not reveal anything pathological. Dermatological examination revealed 4 nodular lesions covered with scales and crusts (Figure 1). The lesions were round, 1 cm in diameter, tender and not floating by palpation; the manual pressure induced some pain. Also after scales and crusts removal, no orifice was visible on the surface of the nodules. Moreover, the lesions did not drain any purulent material. A clinical diagnosis of myiasis was made. In order to confirm this diagnosis, an ultrasound examination was performed. It showed 4 teardropshaped, segmented, hyperechoic areas, with hypoechoic rim and a well defined link crossing the dermis and leading to the surface (Figure 2). No larva movements were detected at realtime Doppler ultrasound scanning, while a scant surrounding vascular flow was present, most probably due to oedema and inflammation (Figure 3). The surgical removal of the dead larvae was performed in Brazil, where the suspect of Dermatobia hominis myiasis was confirmed.

Skin Research and TechnologyVolume 24, Issue 4 p. 701-703 LETTER TO THE EDITOR Rosacea-like cutaneous localization of small lymphocytic lymphoma unmasked by high-frequency-ultrasound G. Genovese, Corresponding Author G. Genovese [email protected] orcid.org/0000-0002-7636-958X Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy Correspondence Giovanni Genovese, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, 20122 - Milano, Italy. Email: [email protected]Search for more papers by this authorG. Nazzaro, G. Nazzaro Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this authorS. Alberti Violetti, S. Alberti Violetti Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this authorE. Passoni, E. Passoni Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this authorE. Berti, E. Berti Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this author G. Genovese, Corresponding Author G. Genovese [email protected] orcid.org/0000-0002-7636-958X Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy Correspondence Giovanni Genovese, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace, 9, 20122 - Milano, Italy. Email: [email protected]Search for more papers by this authorG. Nazzaro, G. Nazzaro Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this authorS. Alberti Violetti, S. Alberti Violetti Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this authorE. Passoni, E. Passoni Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this authorE. Berti, E. Berti Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, ItalySearch for more papers by this author First published: 23 May 2018 https://doi.org/10.1111/srt.12586Citations: 6Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume24, Issue4November 2018Pages 701-703 RelatedInformation

PURPOSE:Early breast cancer follow-up guidelines for patients who underwent surgery suggest a regular and accurate clinical examination of the breast area, for an early identification of cutaneous or subcutaneous breast cancer relapse. Nonetheless, breast skin lesions arising in patients treated with mastectomy for breast cancer can be caused by several diseases. A series of diagnostic hypotheses should be considered, not only focusing on cutaneous metastasis, but also on dermatologic and systemic diseases.CASE REPORT:In February 2015, a 37-year-old patient underwent a right subcutaneous mastectomy for stage IIA breast cancer. Five months after beginning adjuvant chemotherapy, she noted hyperpigmentation and thickening of the skin on the right breast. Differential diagnosis included local relapse, skin infection, lymphoma, or primary cutaneous disease, and a skin biopsy was performed. The histopathologic specimen showed full-thickness sclerosis, with features of localized morphea. Therapy with clobetasol was prescribed, with progressive resolution of the thickness. The collaboration between many professionals in a multidisciplinary team (oncologist, dermatologist, plastic surgeon, and pathologist) was crucial to achieving the diagnosis.CONCLUSION:In the literature, some articles describe correlation between connective tissue diseases and silicone breast implants, but the pathogenetic mechanisms are unknown. We report a rare case of breast morphea after positioning a silicone implant in a patient who had undergone mastectomy. This clinical report represents an interesting model of multidisciplinary management of a patient with breast cancer who developed an uncommon dermatologic disease. Further studies are needed to clarify the association between silicone implants and breast morphea.

Indeterminate cell histiocytosis (ICH) is a proliferation of indeterminate CD1a+, CD68+, S100+ and CD207- dermal dendritic cells. We describe a 39-year-old man who developed diffuse ICH and, 6 years later, acute myeloblastic leukaemia (AML). He was treated with cyclophosphamide, etoposide and vinblastine until 2003. In August 2004, he presented dyspnoea, hyperpyrexia and infiltration of the lung parenchyma, compatible with an AML invasion, and died after a course of induction chemotherapy. Cytomorphology and immunophenotype analyses suggested an ICH clonal evolution. The leukaemogenic role of etoposide is discussed. ICH has previously been reported in association with B-cell malignancy, but only one case has shown systemic progression.

British Journal of DermatologyVolume 153, Issue 1 p. 206-207 Chemotherapeutic experience in indeterminate cell histiocytosis R. Caputo, R. Caputo Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this authorA.V. Marzano, A.V. Marzano Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this authorE. Passoni, E. Passoni Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this authorM. Bellinvia, M. Bellinvia Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this author R. Caputo, R. Caputo Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this authorA.V. Marzano, A.V. Marzano Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this authorE. Passoni, E. Passoni Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this authorM. Bellinvia, M. Bellinvia Istituto di Scienze Dermatologiche, University of Milan, Via Pace 9, 20122 Milan, Italy, IRCCS Ospedale Maggiore of Milan, ItalySearch for more papers by this author First published: 05 July 2005 https://doi.org/10.1111/j.1365-2133.2005.06644.xCitations: 26 Dr Angelo Valerio Marzano E-mail: monicabellinvia@hotmail.com Conflict of interest: None declared Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume153, Issue1July 2005Pages 206-207 RelatedInformation