The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis and treatment, including the occurrence, development, progression, metastasis, and treatment of oncologic disease. It covers basic, translational and clinical research related to cancer cell biology, genomics, precision medicine, oncology internal medicine, radiotherapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neurooncology, etc.

Objective: To evaluate whether epilepsy or certain antiepileptic drugs render patients prone to develop low bone mineral density (BMD) and osteoporosis risk.Methods: Thirty-eight (27 males, 11 females) consecutive adult epileptic patients receiving antiepileptic drugs (AEDs) and 71 control individuals matched for race, gender, age and body mass index (BMI) were subjected to dual energy X-ray absorptiometry (DXA).Results: The mean lumbar spine and total hip BMD values were lower in the patients compared to control group (0.90 +/- 0.24 g/cm(2) vs 1.04 +/- 0.14 g/cm(2), p < 0.001 and 0.92 +/- 0.14 g/cm(2) vs 0.99 +/- 0.13 g/cm(2), p = 0.02, respectively). At the same skeletal sites, male patients had significantly reduced BMD compared to control males (0.90 +/- 0.21 g/cm(2) vs 1.03 +/- 0.15 g/cm(2), p = 0.004 and 0.93 +/- 0.14 g/cm(2) vs 1.02 +/- 0.13 g/cm(2), p = 0.009, respectively) while there was a trend but no significant differences in females. This BMD reduction was independent of AED type.Conclusion: Adult epileptic, predominantly male patients have lower BMD and could be screened with densitometry for early diagnosis and prevention of osteoporosis. (C) 2015 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.

PURPOSE:To evaluate the cardiac toxicity of radiotherapy (RT) in breast cancer (BC) patients employing myocardial perfusion imaging (MPI) with Tc-99 m Tetrofosmin-single photon emission computer tomography (T-SPECT).MATERIALS AND METHODS:We studied 46 BC female patients (28 patients with left and 18 patients with right BC) treated with postoperative RT compared to a control group of 85 age-matched females. The median time of RT to SPECT was 40 months (6-263).RESULTS:Abnormalities in the summed stress score (SSS) were found in 54% of left BC patients, 44.4% of right BC patients, and 32.9% of controls. In left BC patients there were significantly more SSS abnormalities compared to controls (4.0 ± 3.5 vs 2.6 ± 2.0, p = 0.05) and possible trend of increased abnormalities of right BC patients (3.7 ± 3.0 vs 2.6 ± 2.0, p = 0.14). Multiple regression analysis showed more abnormalities in the MPI of left BC patients compared to controls (SSS, p = 0.0001); Marginal toxicity was also noted in right BC patients (SSS, p = 0.045). No additional toxicity was found in patients that received adjuvant cardiotoxic chemotherapy. All T-SPECT abnormalities were clinically silent.CONCLUSION:The study suggests that radiation therapy to BC patients result in MPI abnormalities but without apparent clinical consequences.