In this study, the germanium detector assembly, installed at the Accurate Neutron-Nuclear Reaction measurement Instruments (ANNRI) in the Material and Life Science Facility (MLF) operated by the Japan Proton Accelerator Research Complex (J-PARC), has been characterized for extension to the measurement of the angular distribution of individual gamma-ray transitions from neutron-induced compound states. We have developed a Monte Carlo simulation code using the GEANT4 toolkit, which can reproduce the pulse-height spectra of gamma-rays from radioactive sources and (n,gamma) reactions. The simulation is applicable to the measurement of gamma-rays in the energy region of 0.5-11.0 MeV.

There is a need for a high-counting-rate neutron detector in order to search for CP-violations using compound nucleus resonances.A pixel-type detector based on a Li-glass scintillator, called the LiTA detector, is one candidate for this search.We measured the performance of this detector at MLF, J-PARC, and confirmed that it is usable up to a counting rate of 0.8 Mcps/cm 2 .A boron-loaded liquid scintillator is another candidate for the high-counting-rate detector.The 3.7 ns decay time of this scintillator is shorter than that of the Li-glass scintillator.However, this liquid scintillator is sensitive to both neutrons and gamma rays.Pulse-shape analysis to remove the undesired gamma-ray signals was attempted.

"Neutron Optics and Physics (NOP/ BL05)" at MLF in J-PARC is a beamline for studies of fundamental physics. The beamline is divided into three branches so that different experiments can be performed in parallel. These beam branches are being used to develop a variety of new projects. We are developing an experimental project to measure the neutron lifetime with total uncertainty of 1 s (0.1%). The neutron lifetime is an important parameter in elementary particle and astrophysics. Thus far, the neutron lifetime has been measured by several groups; however, different values are obtained from different measurement methods. This experiment is using a method with different sources of systematic uncertainty than measurements conducted to date. We are also developing a source of pulsed ultra-cold neutrons (UCNs) produced from a Doppler shifter are available at the unpolarized beam branch. We are developing a time focusing device for UCNs, a so called "rebuncher", which can increase UCN density from a pulsed UCN source. At the low divergence beam branch, an experiment to search an unknown intermediate force with nanometer range is performed by measuring the angular dependence of neutron scattering by noble gases. Finally the beamline is also used for the research and development of optical elements and detectors. For example, a position sensitive neutron detector that uses emulsion to achieve sub-micrometer resolution is currently under development. We have succeeded in detecting cold and ultra-cold neutrons using the emulsion detector.

The MTV (Mott Polarimetry for T-Violation) experiment is running at TRIUMF-ISAC (Isotope Separator and ACcelerator), searching for a large T violation in polarized Li-8 beta decay via measurements of the triple vector correlation, R, in the beta decay rate function. The left/right backward scattering asymmetry of Mott scattering from a thin metal foil is measured using an electron tracking detector including a cylindrical drift chamber (CDC). To achieve 10-ppm precision in the Mott scattering asymmetry, we performed multiple studies on the expected systematic effects. The sources of the systematics have been identified and calibration systems have been developed to evaluate the fake effects. The first physics data was collected in 2016 and significantly improved on the result of our previous measurement, which achieved 100-ppm precision in 2010 using the first generation detector (planer drift chamber) at TRIUMF. The data measurement status, together with the results of the systematics studies, is described here. In addition to the T violation, we are preparing to test the Lorentz invariance in the weak sector via our Mott analyzer system. Unexplored Lorentz violating correlations can be tested using the MTV experimental setup. The testing principle and preparation status are also described here.

The MTV experiment (Mott Polarimetry for T-Violation Experiment) is running at TRIUMF, to search for a large T-violating transverse electron-polarization in polarized 8Li β-decay. We aim at reaching precision of 10−4 for the R-correlation, which is defined as a T-violating triple vector correlation in the β-decay rate function. A Mott polarimeter system using a CDC (Cylindrical Drift Chamber) is used to measure the left-right scattering asymmetry in the Mott scattering from a thin metal foil. In the present study, we aim to discuss systematic effects in Mott polarimetry using the CDC.

The interactions between leukopenia induced by vinblastine and the cyclooxygenase inhibitor indomethacin on the toxicity of tumor necrosis factor (TNF) were studied. When indomethacin was injected 60 min before the administration of recombinant TNF, it provided significant protection against rapid killing by TNF; leukopenia also prevented the toxic action of TNF. However, their inhibition of the activity of TNF was not sufficient, and 17-25% of the rats died within 48 hr following TNF administration. Every rat that received peritoneal polymorphonuclear leukocytes (PMNLs) died within 24 hr following the administration of TNF. On the other hand, administration of indomethacin to the rats in leukopenia prevented the toxic action of TNF completely, and all rats lived for 48 hr and showed no changes, compared to normal rats, in hematocrit, plasma transaminase, and body temperature. From these findings, the toxic action of TNF seems to result from increases in synthesis of prostaglandins (PGs) and activation of PMNLs.