目的 观察急性肠粘膜损伤大鼠体表伊文思蓝(Evans Blue,EB)渗出点分布情况.方法 SD雄性大鼠30只,按5％、7.5％、10％、12.5％、15％芥子油浓度随机分组,每组6只.采用肠道注射芥子油造成急性肠粘膜损伤模型,造模后4小时背部备皮、尾静脉注射EB,分别观察造模后5小时、10小时、15小时、20小时、25小时EB渗出点的分布.采用经纬网格计数结合多元统计分析的方法,分析EB渗出点随浓度与时间变化的分布规律.结果 造模后25小时内各浓度芥子油组大鼠均存活.①聚类分析渗出点在S1、N1、O14、L11网格分布特异性突出,轮廓分析结果表明上述四个"特征网格"在不同浓度与不同时间变化无明显差异(P>0.05).②因子分析渗出"特征区域"在距正中线旁约0～10 mm或15～20 mm范围内分布较多.轮廓分析结果表明,在各时间点随浓度变化的EB渗出"特征区域"有显著性差异(P<0.05).在各个浓度随时间变化的EB渗出"特征区域"无明显差异(P>0.05).结论 急性肠黏膜损伤大鼠EB渗出网格点分布规律主要在胸腰段的脊柱两侧,特征区域分布与大鼠肺、脾俞及肾俞相近,并存在与病情变化相关的规律性.

Objective:To observe the clinical effect of meridian-collateral scraping therapy on active rheumatoid arthritis.Methods:60 cases with rheumatoid arthritis were randomly divided into a control group and a treatment group,30 cases of each.The control group was treated with methotrexate and hydroxychloroquine; while the treatment group,based on the treatment of the control group,was treated with meridian-collateral scraping therapy.After a 3-month course of treatment,the time of morning stiffness,HAQ score and DAS28 score of the two groups were observed.Results:The time of morning stiffness of the two groups was shortened and the HAQ score was lowered,but the treatment group was better than the control group (P< 0.05).The DAS28 score of the two groups was reduced,there being no signiifcant differences between groups (P> 0.05).Conclusion:For patients with active rheumatoid arthritis,meridian-collateral scraping can improve the symptoms of morning stiffness,joint function and their life quality.

<正>现代的多方位研究提示:穴位的功能活动是一个动态的概念,在生理状态下以"沉寂"为主,活动微弱甚至感觉不到它的存在,而在病理状态下则具有和生理状态完全不同的特征,穴区反映疾病和治疗疾病的功能大大加强,其面积的大小也会产生相应的变化,这一特征称为穴位的敏化[1-2],这种"敏化"是穴位反映疾病的具体体现,也是指导临床选穴和提高临床疗效的核心。其关键在于与病理相关,与机体的疾病过程相关,即

Objective Observed ear pressure treating adolescent insomnia pill clinical efficacy.Methods 68 cases of young patients with insomnia were randomly divided into two groups,control group,34 patients treated with acupuncture treatment group,34 patients treated with ear pressure pill method.Treatment using Pittsburgh sleep quality index rating scale (PSQI),a comprehensive analysis and valuation.Results The test group after treatment of sleep quality,sleep efficiency improved significantly than in the control group,there are statistically significant(P0.05).But the two sets of total sleep score were not significantly different(P0.05).Conclusion Using ear pressure pill method for treatment of insomnia with acupuncture treatment of the disease are quite effective,but the ear acupuncture pressure pill law is less convenient,simple, easy to operate and safe.