The Ya’nan sag has experienced more than 40 years of exploration, but only the Ya 13-1 large gas field has been found. In recent years, no oil or gas field has been found, and exploration work is difficult. To clarify the main controlling factors of the oil and gas reservoirs in Ya’nan Sag, the direction of oil and gas exploration is highlighted. Based on 3D seismic data combined with drilling information, this paper determines the basic geological conditions, clarifies the main controlling factors of reservoir formation, and predicts strong exploration directions. The research revealed the following: ① The source rocks of the Yacheng Formation in the Ya’nan sag are developed, and the types are II2-III, with excellent resource potential. ② In-depth analysis of the drilled wells revealed that high-quality reservoirs, oil-source faults, and caprock conditions are the main controlling factors of hydrocarbon accumulation in Ya’nan sag.

OBJECTIVE:To investigate the clinical characteristics of systemic lupus erythematosus accompanied by autoimmune liver cirrhosis (SLE-ALC) patients and differences from the non-cirrhosis group.METHODS:Forty-three patients with SLE-ALC were enrolled in this study from 2653 patients with SLE in Peking University People's Hospital. A descriptive case-control study was performed between SLE-ALC patients and the entry time-matched non-cirrhosis group.RESULTS:Among the 43 SLE-ALC patients, 41 (95.3%) were female. Eight patients (18.6%) were first found to have cirrhosis and then diagnosed with SLE. Eighteen patients (41.9%) had jaundice and 27 (62.8%) had esophageal and gastric varices. The age of SLE-ALC patients was 51.1 ± 17.2 years, which was significantly older than the non-cirrhosis group (P < 0.001). Lung involvement was more common as initial manifestations in SLE-ALC patients during the SLE course (P=0.027). Compared with the non-cirrhosis group, SLE-ALC patients had worse liver function. A significantly higher rate of hematological system involvement (anemia, leucopenia, and thrombocytopenia) and a higher level of immunoglobulins were observed in SLE-ALC patients (P<0.05). Moreover, SLE-ALC patients displayed a lower positive rate of anti-double-stranded DNA and anti-ribosomal P protein (P<0.05). The most common radiologic manifestations are ascitic fluid (72.1%) and splenomegaly (71.4%) in SLE-ALC patients. Six SLE-ALC patients underwent liver biopsy, and interface hepatitis was present in all patients.CONCLUSIONS:Cirrhosis is rare in SLE patients but is manifested as a unique pattern of clinical features characterized by late-onset age, lung involvement, high immunoglobulins, and impaired liver function.

High-temperature and high-pressure (high-grade) metamorphic complexes of variable ages are common in the Central Asian orogenic belt (CAOB), and their precise geochronology and origin are essential to unravel the orogenic architecture and crust-production rate of the CAOB. Hereby it is essential to differentiate between pre-orogenic Precambrian basement and Paleozoic arc-accretionary complexes. This study provides precise in situ zircon U−Pb ages for the metasedimentary rocks in the Wuwamen ophiolitic mélange, which is traditionally thought to represent the pre-orogenic basement of the southwestern CAOB. A meta-sandstone from the meta-flysch sequence revealed a widespread ca. 1.8 Ga high-grade metamorphic overprint similar to that of the underlying orthogneisses and, thus, was interpreted to represent pre-orogenic basement fragments that occur as tectonic blocks in the Paleozoic ophiolitic mélange. In contrast, a schist from the mélange matrix is characterized by a ca. 333 Ma high-grade metamorphic overprint, indicating that the northward subduction of the South Tianshan Ocean was still active at this time. The thrust-imbricated high-grade metamorphic rocks of contrasting origins in an accretionary complex have important implications for the understanding the accretionary history and crustal growth of the CAOB. Furthermore, the strongly deformed ophiolitic mélange was intruded by an undeformed granite dyke with an emplacement age younger than ca. 294 Ma, thus providing a minimum age limit for the final closure of the South Tianshan Ocean.

Background: NUT carcinoma is a rare aggressive squamous cell carcinoma subtype genetically characterized by NUTM1 rearrangements. NUT carcinoma can be easily misdiagnosed as an undifferentiated carcinoma or Ewing sarcoma due to its primitive differentiation. Case presentation: We report a case of renal-derived NUT carcinoma diagnosed as a malignant small round-cell tumor resembling Ewing sarcoma/primitive neuroectodermal tumor where the diagnosis was revised to NUT carcinoma with a characteristic NUTM1 rearrangement based on next-generation sequencing (NGS). The patient received a standard NUT carcinoma treatment after recurrence but died of first-line chemotherapy failure due to advanced neoplasm progression. Conclusion: Routine NUT immunohistochemistry staining, NGS, and/or fluorescent in situ hybridization for poorly differentiated carcinoma and sarcoma can help avoid misdiagnosis of NUT carcinoma-related tumors, allowing patients to benefit from bromodomain and extra-terminal motif inhibitor therapy.

Retroperitoneal fibrosis (RPF) is an uncommon condition characterized by inflammation and fibrosis in the retroperitoneal space. More than two-thirds of RPF are idiopathic, with the remaining stemed from a variety of secondary causes. It was suggested that IgG4-related RPF is a secondary form of RPF. We undertook this study to compare detailed demographic, clinical and laboratory characteristics of IgG4-related RPF and IRPF in a large Chinese cohort. We retrospectively reviewed the medical records of 132 RPF patients diagnosed at Peking University People's Hospital between March 2010 and March 2018. Among the 132 patients, the mean age at disease onset was 54.8 years. IgG4-related RPF group showed greater male predominance compared to IRPF group. IgG4-related RPF patients showed a longer interval between symptom onset and diagnosis, and allergic diseases were more common in this group. Sixty-four patients (48.4%) had lower back pain, which was more common in IRPF group than that in IgG4-related RPF patients. In terms of organ involvement, although 42 of 47 patients (89.3%) with IgG4-related RPF had other organ involvement, there were no patients in the IRPF group with other organ involvement. In addition, the serum IgG4 level, elevated eosinophils counts and IgE level were significantly higher in IgG4-related RPF patients. We described the demographic, clinical and laboratory differences between IgG4-related RPF and IRPF patients, indicating their potential differences in pathogenesis, which was of great importance to diagnose and manage the two phenotypes.

It is of great significance to research spatial-temporal variations of groundwater tables from the perspective of the whole groundwater variable field in a basin. In this study, the original observation matrix was constructed using 38 monitoring wells data from 1984 to 2019 in the Heihe River Basin in the middle section of the Hexi Corridor and processed to be centered and standardized, respectively. The empirical orthogonal function (EOF) method was used to decompose the transformed matrices to obtain spatial and temporal variation patterns of groundwater tables which were represented by the spatial weights of typical uncorrelated modes with the corresponding temporal functions (TF). The resulting main variation pattern showed general drops in regional groundwater tables for both centered and standardized cases, especially in the southeast regions when using centered EOF modes. The second to fifth modes presented reverse distribution characteristics from the northwest to southeast directions. The downward trend in the first TF series indicated that the groundwater depth of the whole basin varied to be deeper. The local rise occurring at some sites demonstrated the positive effects of continuous ecological water delivery since 2000, but was still not recovered to the previous level due to long-term serious groundwater overdrawing.

OBJECTIVE:The growing utilization of needle biopsy has challenged the current pathology consensus of IgG4-related disease (IgG4-RD). The aims of this study were to identify the histological characteristics of needle biopsy and surgical specimens and evaluate the ability of needle biopsy in histological diagnosis of IgG4-RD. METHODS:Biopsies from patients who were referred to as IgG4-RD by the 2019 ACR/EULAR IgG4-RD classification criteria in Peking University People's Hospital from 2012 to 2019 were re-evaluated. Typical histological features and diagnostic categories were compared between needle biopsy and surgical biopsy. RESULTS:In total, 69 patients met the 2019 ACR/EULAR classification criteria and 72 biopsies of them were re-evaluated. All cases showed lymphoplasmacytic infiltrate, while storiform fibrosis and obliterative phlebitis were only present in 35 (48.6%) and 23 (31.9%) specimens, respectively. Storiform fibrosis was more likely to be seen in retroperitoneum lesion (P = 0.033). Surgical biopsy showed significantly higher IgG4+ plasma cells/high-power field (IgG4/HPF) count (P < 0.01) and higher proportion of IgG4/HPF > 10 (P < 0.01). No significant difference was observed with regard to the ratio of IgG4+ plasma cells/IgG+ plasma cells (IgG4/IgG) (P = 0.399), storiform fibrosis (P = 0.739), and obliterative phletibis (P = 0.153). According to the 2011 comprehensive diagnostic criteria, patients who performed a needle biopsy were less likely to be probable IgG4-RD (P = 0.045). Based on the 2011 pathology consensus, needle biopsy was less likely to be diagnosed as IgG4-RD (P < 0.01), especially to be highly suggestive IgG4-RD (P < 0.01). Only 1/18 (5.6%) needle salivary specimens fulfilled the cutoff of IgG4/HPF > 100, which was significantly less than 15/23 (65.2%) of surgical ones (P < 0.01). CONCLUSIONS:Needle biopsy shows an inferiority in detecting IgG4/HPF count but not in IgG4/IgG ratio, storiform fibrosis, and obliterative phlebitis. Compared with surgical samples, needle biopsy is less likely to obtain a histological diagnosis of IgG4-RD. A different IgG4/HPF threshold for needle biopsy of the salivary glands may be considered.

Phosphorus (P) is an important nutrient and has an important impact on global primary productivity. Presently, the dynamics of the P cycle in low sulfate, anoxic settings are largely unknown. In this study, the adsorption-desorption behavior of Fe-bound P, organic-P, loosely-bund P, detrital apatite P, and refractory P was described in the sulfate and methane transition zone (SMTZ) at site 973-4 in the cold-seep area of the Taixinan Basin, South China Sea. Results showed that the Fe-bound P and organic-P were influenced by sulfate-driven anaerobic oxidation of methane (SD-AOM) and metal-driven anaerobic oxidation of methane (MD-AOM), and subsequently, the Fe-bound P and organic-P were released as HPO42- into the pore water. Meanwhile, significant increases were detected in authigenic carbonate fluorapatite (P-C(FA)) and vivianite within the MD-AOM zone, which indicate that this zone is an important P-sink area. The MD-AOM plays an important role in the formation of P CFA and vivianite because MD-AOM provide the necessary HPO42- and Fe2+ for the formation of these minerals. Our findings have major implications for understanding the P cycle in low sulfate, anoxic settings and are important for understanding the influence of MD-AOM on the phosphate cycle.

Objectives. Patients with IgG4-related disease (IgG4-RD) typically respond well to initial glucocorticoid therapy, but always relapse with tapered or maintenance dosage of steroid. We aimed to identify the risk factors for relapse of IgG4-RD and explore the impact of active intervention on the serologically unstable condition. Methods. We performed a retrospective study of 277 IgG4-RD patients at Peking University People's Hospital from February 2012 through February 2019. They were all followed for >4 months. The primary outcome was patient relapse. Data on recurrence of IgG4-RD symptoms, laboratory and image findings were recorded, along with information on treatment in the serologically unstable condition. Results. The cumulative relapse rate was 12.86%, 27.84% and 36.1% at 12, 24 and 36 months, respectively. Younger age at onset, younger age at diagnosis, longer time from diagnosis to treatment and history of allergy were associated with relapse. Identified independent risk factors were longer time from diagnosis to treatment and history of allergy. When serum IgG4 level was 20%, 50% or 100% higher than that of the remission period, similar percentages of patients finally relapsed, regardless of whether they were in the immunosuppression intensified or non-intensified group. Median duration from serum IgG4 level instability to relapse in the intensified and non-intensified group was not statistically different. Conclusion. The risk factors of relapse were longer time from diagnosis to treatment and history of allergy. Intervention in the serologically unstable condition was not helpful for reducing relapse rate.

OBJECTIVES:IgG4-related disease (IgG4-RD) is recently recognized as a fibro-inflammatory condition featured by tumefactive lesions in multiple organs, and the retroperitoneum is one of the common involved sites. We undertook this study to compare detailed demographic, clinical and laboratory characteristics of IgG4-RD patients with retroperitoneum lesion (IgG4-RD RPF+) and retroperitoneum free IgG4-RD (IgG4-RD RPF-) in a large cohort.METHODS:We carried out a retrospective review of the medical records of 407 cases of IgG4-RD diagnosed at Peking University People's Hospital between March 2009 and May 2019.RESULTS:Among 407 patients, 58 had retroperitoneum affected. As compared with IgG4-RD RPF- patients, IgG4-RD RPF+ patients showed older age at disease onset and diagnosis. IgG4-RD RPF+ group involved more male patients. In terms of organ involvement, IgG4-RD RPF+ group was more frequently presented with kidney involvement, while salivary gland, lacrimal gland and pancreas were more prominent in the IgG4-RD RPF- group. In addition, the CRP, ESR level and creatinine level were significantly higher in IgG4-RD RPF+ patients, and hypocomplementemia were more common in this group.CONCLUSION:We have revealed demographic, clinical and laboratory differences between IgG4-RD RPF+ and RPF- patients, which indicated potential differences in pathogenesis and important implications for the diagnosis and management of these two phenotypes.

Recent studies have shown that specific geochemical characteristics of sediments can be used to reconstruct past methane seepage events. In this work, the correlation between the Sr/Ca and Mg/Ca ratios of sediment samples is analyzed and the sulfate concentration profile in Site C14 from cold-seep sediments in the Qiongdongnan Basin in northern South China Sea is obtained. The results confirmed that, sulfate at 0-247 cm below sea floor (Unit I) is mainly consumed by organic matter sulfate reduction (OSR), while sulfate at 247-655 cm (Unit II) is consumed by both the OSR and the anaerobic oxidation of methane (AOM). In addition, the bottom sediment layer is affected by weak methane seepage. The Mo and U enrichment factors also exhibit similar trends in their respective depth profiles. The responses of trace elements, including Co/Al, Ni/Al, Cr/Al and Zn/Al ratios to methane seepage allowed the study of depositional conditions and methane seepage events. Based on the results, it is speculated that the depositional conditions of Unit II changed with depth from moderate conditions of sulfidic and oxic conditions to locally anoxic conditions, and finally to suboxic conditions due to methane fluid leakage. The stable isotope values of chromium-reducible sulfide produced by AOM and those of sulfide formed by OSR in the early diagenetic environment suffered serious depletion of 34S. This was probably due to weak methane leakage, which caused the slower upward diffusion and the effect of early diagenesis on the samples. It is necessary to consider the effects of depositional environments and diagenesis on these geochemical parameters.

The Jiulong Methane Reef, located on the northern slope of the South China Sea, is characterized by several features, such as bottom-simulating reflections and authigenic carbonates, which are indicative of methane seeps that are currently occurring as well as those that occurred in the past. However, to date, the effect that these methane seeps have on the sedimentary environment is not completely clear. To provide further insights into the biogeochemical processes involved in methane seeps, a 6.73 m piston core (973-2) was retrieved from this area in 2011 to perform an in-depth analysis. The chronology of the core has been established by [Formula: see text] dating, and sedimentary events since the last glacial period have been recorded. The results indicate abnormally low abundance and diversity, as well as high infaunal percentages of benthic foraminiferal assemblages in the lower part of the core from 673 to 350 centimeters below the sea floor (cmbsf), indicating impacts from methane activities. Major elemental barium, bromine, and titanium, which serve as proxies of the paleoproductivity, organic contents, and terrestrial supply, respectively, are found to make little contribution in [Formula: see text] content. However, regardless of the factors mentioned above, the [Formula: see text] content is still higher in the lower part of core, indicating the presence of authigenic carbonates. In addition, the total organic carbon/total sulfur ratios of less than 400 cmbsf are found to be beyond the normal range, which is [Formula: see text], reflecting the effects of methane oxidation. In one of the sections, the trace metals and molybdenum profiles show enrichments that are closely related to those of the methane seeps. The results indicate that this area experienced methane seep events in the last glacial period.

A novel complex nanostructured TiO2 electrode and fabrication process were proposed and demonstrated to improve the performance of dye-sensitized solar cells (DSSCs). In the proposed process, a nanoporous TiO2 layer was firstly fabricated on the FTO (fluorine-doped tin oxide) conducting substrate by an anodization process, then a nanoparticulate TiO2 film was deposited on the nanoporous TiO2 layer by the screen printed method to form the complex nanostructured TiO2 electrode. The experiments demonstrated that the nanoporous TiO2 layer can enhance the light scattering, decrease the contact resistance between TiO2 electrode and FTO, and suppress the recombination of I 3 − ion with the injected electrons of FTO. The process variables are crucial to obtain the optimized performance of DSSCs. By adopting the optimized process, improved conversion efficiency of DSSCs was achieved at AM 1.5 sunlight.