1. Malondialdehyde (MDA) levels of erythrocyte membranes of sickle-cell disease patients were measured as an indicator of peroxidative damage and allopurinol was used as a lipid peroxide scavenger. 2. Incubating sickle-cell erythrocytes with allopurinol significantly reduced MDA levels of erythrocyte membranes compared with before-treatment values. 3. Allopurinol seems to reduce the peroxidative damage in sickle-cell erythrocytes, but the mechanism is still unknown.

The purpose of this prospective study was to investigate the levels of Lp(a), Apo(a), VLDL, LDL and HDL in 23 patients with pregnancy induced hypertension (PIH) and in 20 control. The Mann-Whitney U tests was used for comparisons between the two groups. Serum Lp(a) and Apo(a) levels were significantly raise in the PIH group (p<0.05 and p<0.05 respectively) and no significant correlations could be demonstrated for other lipoproteins.

1. The effect of topical CCNU treatment on lipid peroxidation of glial tumors transplanted on rat brain has been investigated in 22 rats. 2. Four groups have been selected as normal brain tissue, normal brain tissue+CCNU, tumour tissue, tumour tissue+CCNU. In these groups malondialdehyde (MDA) levels have been measured as a marker of lipid peroxidation. 3. Lipid peroxidation was high in tumour tissue in respect to controls (P < 0.05). In normal tissues topical CCNU treatment caused increase in lipid peroxidation (P < 0.05). In tumor tissues, topical CCNU decreased lipid peroxidation (P < 0.05). It is concluded that further studies have to be performed in order to determine whether increases in lipid peroxidation on CCNU treated normal brain tissues is a result of the inhibitory effect on cellular defence systems or promotion of free radical production.

The activity of Na+,K(+)-ATPase in the microsomal fraction of rabbit kidney cortex was strongly decreased by ischemia and increased slightly, but not significantly, after reperfusion. These changes were correlated with a dramatic increase in lipid peroxidation in microsomes isolated from both ischemic and reperfused kidneys. This correlation may point to irreversible impairment of the enzymatic function under the influence of either oxygen free radicals or lipid peroxidation.

İnsan kan serumunda Avustralya antij eni tayininde antiko ı la kaplanmış lateks partikülleri aglitünasyonu metodu, tekni ğin basitliği ve çabukluğu yönünden özellikle diğer tekniklerden faydalanılması mümkün olmayan hallerde faydalan ılabilir bir metod olarak gözükmektedir. Bu metoddan faydalanarak yapt ığımız araştırmalarda 100 sağlı klı öğrenciden sadece birisinde yalanc ı pozitif reaksiyona, karaci ğer hastalığı dışındaki sebeplerle hastanelerde bulunan ve transaminaz aktivitesi normal olan 411 hasta serumundan 5 tanesinde pozitif reaksiyona raslad ı k. Yaptığımız bu araştırmada, kendileri sarılık veya karaciğer hastalığı geçirmedikleri halde kan serumlarında Avustralya antijeni bulunan kimselerin orantı sı nın %0.978 civarı nda olduğu tesbit edilmi ştir. Bu sonuç ve diğer araş tırıcıların değişik metotlarla elde ettikleri sonuçlar memleketimizde görünüşte sağlam olan kimselerden kanlar ında Avustralya antijeni tesbit edilenlerin orant ı sını n diğer batı ülkelerine kıyasla yüksek olduğunu göstermektedir. Ancak bu orant ının bölgelere göre kesilnikle saptanabilmesi için daha geni ş araştırmalara ihtiyaç vardır.