Detection of chromosomal rearrangements involving tyrosine kinase genes such as ALK, NTRK1, ROS1 is of great importance for diagnosis of non-small cell lung cancer (NSCLC) and selection of targeted therapies. Herein, we present an extended, multiplexed Oncomine targeted RNA sequencing research assay for detection of fusion transcripts and intragenic rearrangements (exon deletion/skipping). In addition, we present our studies towards development of a transcript-based expression imbalance research assay designed to identify gene fusions in a partner agnostic manner, and apply the method for multiple key driver genes as a potential complementary method to our core fusion detection method.
S. Sadis合作论文数4P. Williams合作论文数4
Fiona Hyland合作论文数Applied Markets, Applied Biosystems/Life Technologies4
John H. Bishop合作论文数Cornell University3
Goutam J Nistala合作论文数Department of Agricultural and Biological Engineering, University of Illinois at Urbana Champaign3Charles R. Scafe合作论文数3Jon Sherlock合作论文数3A. Broomer合作论文数2S. Myrand合作论文数2J. Kilzer合作论文数2E. Wong-Ho合作论文数2C. Yang合作论文数2Amir Marcovitz合作论文数Dept Dev Biol, Stanford Univ2Y. Tseng合作论文数2
Manimozhi Manivannan合作论文数Mission Bio2Vikas Mittal合作论文数2
Nitika Garg合作论文数School of Marketing, Business School, The University of New South Wales2
Dumitru Brinza合作论文数Ultima Genomics2H. Hamidi合作论文数1S. Roman合作论文数1Rongsu Qi合作论文数1
Jeoffrey J Schageman合作论文数1
