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Ex-type culture of Spicellum roseum isolated from silage in France has been known to produce some trichothecenes. As the causative agent of the pink mold damping-off disease, we isolated some strains of S. roseum from a cultivated mushroom Flammulina velutipes at Nagano, Japan. To examine whether the Japanese strains of S. roseum produce trichothecenes or not, the isolates were cultivated on rice medium and extraction was made for mycotoxin analysis. 8-Deoxy-trichothecin was accordingly detected and confirmed with GC/MS by means of EI and CI mode. However, deoxynivalenol, 3-acetyldeoxynivalenol, fusarenon-X and nivalenol were not detected in the extract, all of which are well known to be detected from scabby wheat.

A new cell growth inhibitor, curvularol, was isolated from the fermentation broth of Curvularia sp. RK97-F166. Curvularol showed no antibacterial activity, and very weak antifungal activity. However, curvularol inhibited the cell cycle progression of normal rat kidney (NRK) cells in G1 phase at 150 ng/ml. Curvularol induced the morphological reversion of srcts-transformed NRK cells at 100 ng/ml, and inhibited protein synthesis same as cycloheximide.