From ancient history, complementary and alternative medicines have played a significant role as holistic therapeutic treatments of various human diseases including cancer, diabetes, neurological diseases, and skin problems. One Indian medicinal plant (herb), Bacopa monnieri has been used in many parts of the world as such medicine, particularly for the treatment of various neurological disorders. It is well known as a potent “tonic for the human brain,” which serves as a memory enhancer. Multiple studies proved that this herb contains a plethora of potential bioactive, phytochemical compounds with synergistic properties. The main purpose of the present review is to shed light on the use of Bacopa monnieri and its active principles (bacosides) in the management of neurological disorders. Furthermore, the signaling pathways modulated by bacosides have been critically discussed in this review. Moreover, we have critically summarized the present knowledge of this perennial creeping herb based upon the literature mining from different scientific engines.

Copyright: © 2015 | Author(s), This is an open access article under the terms of the Creative Commons AttributionNon-Commercial No Derivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made. In the present study correlation between the body and testis weight with that of mean plasma testosterone concentration was investigated from the pteropid bat, Pteropus giganteus giganteus. The cyclic variations in the body and testis weight were found to in consonance with the hormonal fluctuations. The total body and testis weight beginning to rise in July-August which is after 1-2 months after food availability (mango fruiting) in the local study area of this bat. And then, further reach to its peak level during Oct-Nov. which may be correlated with higher mean plasma concentration. Early rise in the body and testis weight which is complemented by the increase in plasma testosterone concentration may be due to initiation of spermatogenesis. Availability of food may act as stimulus for the onset of spermatogenesis.