Synthetic second generation chemotherapeutic platinum analogs are presently being tested to identify an analog with greater antitumor activity, but less ototoxicity and nephrotoxicity than cisplatin. The objective of this study was to analyze potential vestibular effects of cisplatin and of the two platinum analogs, CBDCA (cis‐diammine 1,1‐cyclobutane dicarboxylato [2]‐0,0 platinum or JM‐8) and CHIP (cis‐dichlorotransdihydroxybisisopropylamine platinum [IV] or JM‐9) using scanning and transmission electron microscopy of vestibular neuroepithelium from the albino guinea pig. Vestibular neuroepithelial damage was not demonstrated in either cisplatin‐ or the analog‐treated animals when administered at equitoxic doses.