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1New Multi-Bridged Cryptands - Polyazamacrocyclic Schiff-Bases Formed in A Tetrapode Capping Reaction

BP CLARK,JR HARRIS,GH TIMMS,JL OLKOWSKI

Multi-bridged cryptands were formed in one step by condensation of two moles of a tetraaldehyde with four moles of a triamine. This is the first example of a tetrapode capping reaction.

1995TETRAHEDRON LETTERS（1995）引用：12

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2Stereoselectivity in the Catalytic Hydrogenation of an Enamine. Selective Formation of EitherCIS- Ortrans- Tertiary Amines

DC HORWELL,GH TIMMS

Conditions have been found where catalytic hydrogenation of the enamine (II) may produce either the trans-2- (3,4-dichlorophenyl) -3 -NN-dimethylaminomethylbicyclo[2,2,2]octane exclusively, or the cis-isomer with high stereoselectivity.

1979SYNTHETIC COMMUNICATIONS（1979）引用：16

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3ChemInform Abstract: POTENTIAL ANTIDEPRESSANT AND CNS STIMULANT ACTIVITY IN A SERIES OF CIS AND TRANS FUSED 3‐AMINOMETHYL‐2‐PHENYLBICYCLO(2,2,2)OCTANE AND ANALOGOUS OCT‐2‐ENE DERIVATIVES

CH CASHIN,J FAIRHURST,DC HORWELL,IA PULLAR, S SUTTON,GH TIMMS,E WILDSMITH,F WRIGHT

AbstractAus dem Cyclohexadien (I) und den isomeren Nitrilen (IIa) bzw. (IIb) werden die Cyanbicyclooctane (IIIa) bzw. (IIIb) synthetisiert, deren Reduktionsprodukte (IVa) bzw. (IVb) zu den Dimethylaminoderivaten (Va) bzw. (Vb) umgesetzt RI werden; die analog (IV) synthetisierten Aminomethylbicyclooctane (VI) werden nach einer modifizierten Eschweiler‐Clarke‐Methode zu den Derivaten (VII) N,N‐dimethyliert Die trans‐Diels‐Alder4Addukte (IX) ‐ zugänglich aus (I) und den trans‐Zimtaldehyden (VIII) ‐ werden durch Bromierung/Dehydrobromierung in die ungesättigten Aldehyde (X) übergeführt; Kondensation der Aldehyde (X) mit Methylamin gibt die entsprechenden Imine, die zu den sek. Aminen (XI) reduziert werden; diese lassen sich analog (VI) zu den tertiären Aminen (XII) umsetzen.

1978EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（1978）

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4ChemInform Abstract: NOVEL BICYCLO(2.2.2)OCTANYL‐1,4‐BENZODIAZEPINONES. THEIR SYNTHESES AND REARRANGEMENT TO BICYCLOOCT‐2‐ENYLBENZIMIDAZOLES

J. FAIRHURST,D. C. HORWELL,G. H. TIMMS

AbstractCyclohexadien (I) reagiert mit 2‐Chlor‐ 3‐nitro‐propionsäureester (II) zu den stereoisomeren Addukten (III) und (IV).

1978Chemischer Informationsdienst

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5Novel Bicyclo[2.2.2]octanyl‐1,4‐benzodiazepinones. Their Syntheses and Rearrangement to Bicyclooct‐2‐enylbenzimidazoles

J FAIRHURST,DC HORWELL,GH TIMMS

AbstractThe synthesis of the novel bicyclo[2.2.2]octanyl[1,4]benzodiazepinone ring system (IV) and its facile acid catalysed rearrangement to the corresponding bicyclo[2.2.2]oct‐2‐enylbenzirnid‐azole system (IX) is described.

1977JOURNAL OF HETEROCYCLIC CHEMISTRY（1977）引用：5

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6A Synthesis of Cis-Α-unsaturated Nitriles by Kinetically Controlled Decarboxylation

J FAIRHURST,DC HORWELL,GH TIMMS

AbstractAus den Aldehyden (I) und Cyanessigsäure (II) entstehen die Kondensate (III), die in Gegenwart von Kupferoxid/Benzol zu den ungesättigten Nitrilen (IV) decarboxyliert werden können.

1975Tetrahedron Letters（1975）引用：13

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7N-Substituted Derivatives of Erythromycylamine.

R RYDEN,GH TIMMS,DM PRIME,E WILDSMITH

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Substituted derivatives of erythromycylamineR. Ryden, Graham H. Timms, Diana M. Prime, and Eric WildsmithCite this: J. Med. Chem. 1973, 16, 9, 1059–1060Publication Date (Print):September 1, 1973Publication History Published online1 May 2002Published inissue 1 September 1973https://pubs.acs.org/doi/10.1021/jm00267a027https://doi.org/10.1021/jm00267a027research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

1973Journal of Medicinal Chemistry（1973）引用：22

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8The Reduction of Oximes with Tervalent Titanium, a Mild Deoximation Procedure and the Partial Synthesis of Erythromycylamine.

GH TIMMS,E WILDSMITH

With the advent of an eco-friendly era, scientists are focusing their attention more on "Greener techniques" for environmental safety reasons. In nature, chemical coupling, reaction control, fine-tuning of the product and use of the outcome of one reaction as a substrate of a next reaction are performed utilizing a well-defined reaction environment through the construction of enormously complex assemblies inside the cells. To mimic Nature, water has been chosen unanimously as benign nonconventional reaction media, not only because in nature, it is the most abundant, cheap, and environmentally friendly but it also exhibits unique chemical reactivity, selectivity, and properties that are different from those performed in volatile and toxic organic solvents. The use of water as a universal reaction media in academia and industry is a unique challenge to the synthetic organic community because reactive substrate, catalyst, reagents might be unsafe in water media. To avoid this difficulty, surfactant-assembled reaction vassals of nanometer dimensions are built up for syntheses of medicinally important heterocycles such as pyrrolines, isoxazolines, isoxazoles, benzimidazoles, pyranopyranes, and their chiral analogs through sustainable catalysis, nanocatalysis, and non-catalytic processes. This book chapter will cover reactions which availed the advantage of using micellar/reverse miller/creation of nanospace/cooperative self-assembled nanoreactors in nonconventional media for developing novel methodologies to address fundamental, practical, and industrial synthetic issues to construct natural and synthetic bioactive heterocycles. This chapter introduces to its readers discussing general organic transformations and syntheses of bioactive compounds in organized micellar aqueous media, which have been accomplished mainly in the past decade or so.

1971TETRAHEDRON LETTERS（1971）引用：115

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9ChemInform Abstract: DIE RED. VON OXIMEN MIT DREIWERTIGEM TITAN, EIN EINFACHES VERFAHREN ZUR DESOXIMIERUNG, PARTIALSYNTH. VON ERYTHROMYCYLAMIN

G. H. TIMMS,E. WILDSMITH

AbstractDas aus Erythromycin (Ia) erhaltene Oxim (Ib) kann durch Behandlung mit Ti(III)‐chlorid zum Imin (Ic) reduziert werden, dessen Isolierung unter speziellen Bedingungen möglich ist.

1971Chemischer Informationsdienst Organische Chemie（1971）

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