Cholangiopancreatoscopy with the SpyGlass system is a direct and minimally invasive examination method in which the lesions in the pancreatic bile tract can be observed directly by inserting an ultra-fine endoscope through the biopsy channel of a duodenoscope. Compared with endoscopic retrograde cholangiopancreatography (ERCP), enhanced computed tomography, magnetic resonance imaging, and endoscopic ultrasonography, cholangiopancreatoscopy with the SpyGlass system has unique advantages for observing and identifying lesions originating in the pancreatic bile duct. In recent years, with the upgrading of endoscopic equipment and the improvement of operating technology, the application of cholangiopancreatoscopy is becoming more and more widespread. This article reviews the use of cholangiopancreatoscopy with the SpyGlass system for the diagnosis and treatment of pancreaticobiliary disease.

Background: Pancreatic cancer (PC) is a highly lethal malignancy of digestive system, and nearly 80 percent of PC patients have lost the chance of surgery due to the lack of early diagnosis. For these patients, the only effective treatment (chemotherapy) is largely limited by drug resistance. Therefore, it is urgent to develop new therapy for PC. Endoscopic ultrasound (EUS) guided Iodine 125 (I125) seeds brachytherapy is a novel way of radiotherapy, and its role in the treatment of advanced malignant tumors is not fully explored. This study is to explore the efficacy of I125 brachytherapy on advanced pancreatic cancer.