SYNOPSIS. An electron microscopic study of the structure of the flagellate Crithidia oncopelti was carried out with particular reference to the nature of the bipolar body which occurs in the organism. Apart from the bipolar body, the fine structure of C. oncopelti is similar to that of the related flagellate, C. fasciculata. The bipolar body is typically a sausage‐shaped organelle limited by 2 unit membranes. Outpouchings of these membranes into the cytoplasm of C. oncopelti were found, along with a constant absence of (a) ribosomes on the outer aspect of the external of the 2 membranes, (b) structures analogous to nuclear pores and (c) an internal structure analogous to a nucleolus. It is concluded that the balance of structural and biochemical evidence favors the idea that the bipolar body is a bacterial protoplast rather than a 2nd nucleus.

Journal Article Determination of molecular weights of dihydrofolate reductases from trypanosomatid flagellates Get access W.E. Gutteridge, W.E. Gutteridge National Institute for Medical Research, Mill Hill, London; and Department of Pharmacology, University of Vermont, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar J.J. Jaffe, J.J. Jaffe National Institute for Medical Research, Mill Hill, London; and Department of Pharmacology, University of Vermont, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar J.J. McCormack, Jr. J.J. McCormack, Jr. National Institute for Medical Research, Mill Hill, London; and Department of Pharmacology, University of Vermont, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 64, Issue 1, 1970, Pages 174–175, https://doi.org/10.1016/0035-9203(70)90226-9 Published: 01 January 1970

Journal Article Presence and properties of dihydrofolate reductases in Trypanosomatid flagellate Get access W.E. Gutteridge, W.E. Gutteridge National Institute for Medical Research, Mill Hill, London Search for other works by this author on: Oxford Academic PubMed Google Scholar J.J. Jaffe, J.J. Jaffe Nuffield Institute of Comparative Medicine, London Search for other works by this author on: Oxford Academic PubMed Google Scholar J.J. McCormack, Jr. J.J. McCormack, Jr. Department of Pharmacology, University of Vermont, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 63, Issue 1, 1969, Page 119, https://doi.org/10.1016/0035-9203(69)90083-2 Published: 01 January 1969