JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 10, Issue 2 p. 103-110 Free Access Medizinprodukte in der Dermatologie: Topische halbfeste Formulierungen zur Behandlung von Hauterkrankungen Hans Christian Korting, Hans Christian Korting Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this authorClaudia Schöllmann, Claudia Schöllmann Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this author Hans Christian Korting, Hans Christian Korting Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this authorClaudia Schöllmann, Claudia Schöllmann Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this author First published: 02 February 2012 https://doi.org/10.1111/j.1610-0387.2011.07764_suppl.xCitations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume10, Issue2February 2012Pages 103-110 RelatedInformation

C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C. albicans interactions is the fungal cell wall, we aimed to identify features of the cell wall inducing epithelial responses and be associated with fungal pathogenesis. We demonstrate here the importance of cell wall protein glycosylation in epithelial immune activation with a predominant role for the highly branched N-glycosylation residues. Moreover, these glycan moieties induce growth arrest and apoptosis of epithelial cells. Using an in vitro model of oral candidosis we demonstrate, that apoptosis induction by C. albicans wild-type occurs in early stage of infection and strongly depends on intact cell wall protein glycosylation. These novel findings demonstrate that glycosylation of the C. albicans cell wall proteins appears essential for modulation of epithelial immunity and apoptosis induction, both of which may promote fungal pathogenesis in vivo.

© 2012 The Authors. doi: 10.2340/00015555-1281 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Glomus tumours are distinctive neoplasms composed of cells resembling the modified smooth muscle cells of the normal glomus body (a specialized form of arteriovenous anastomosis involved in thermal and baroregulation) (1, 2). Vascular tumours with glomus cell morphology occur in two unrelated forms, the glomus tumour per se and the glomuvenous malformation (GVM, OMIM 138000) or glomangioma (3, 4). Clinically, glomangiomas tend to resemble haemangiomas. Differentiation of these entities is important due to their divergent treatment modalities. We report here a case in which multiple glomangiomas were clinically diagnosed as haemangiomas, but histological examination rendered the diagnosis more precisely. The clinical characteristics, differential diagnosis and treatment options of this rare entity are reviewed.

In recent years, topically applied semi-solid formulations certified as medicals devices and not as topical drugs are increasingly used for the treatment of skin diseases. Medical devices primarily unfold their therapeutic effect by physical means, not by pharmacological, immunological or metabolic means. Intensified placing of medical devices on the dermatological market may at least partly be explained by a less complex marketing authorization process compared to topical drugs. If the requirements are fulfilled to certify a product as a medical device the opportunity will be offered to quickly introduce innovations onto the market and propagate them. A variety of evidence-based medical devices for several dermatological indications are presented here.

Excessive scars form as a result of aberrations of physiologic wound healing and may arise following any Insult to the deep dermis. By causing pain, pruritus and contractures, excessive scarring significantly affects the patient’s quality of life, both physically and psychologically. Multiple studies on hypertrophic scar and keloid formation have been conducted for decades and have led to a plethora of therapeutic strategies to prevent or attenuate excessive scar formation. However, most therapeutic approaches remain clinically unsatisfactory, most likely owing to poor understanding of the complex mechanisms underlying the processes of scarring and wound contraction. In this review we summarize the current understanding of the pathophysiology underlying keloid and hypertrophic scar formation and discuss established treatments and novel therapeutic strategies.

Aiming to address new drug targets, molecular modelling is gaining increasing importance although the prediction capability of the in silico method is still under debate. For an improved treatment of actinic keratosis and squamous cell carcinoma, inhibitors of human DNA polymerase alpha (pol alpha) are developed by docking nucleoside phosphonate diphosphates into the active site of pol alpha. The most promising prodrugs OxBu and OxHex were then prepared by total synthesis and tested in the squamous cancer cell line SCC25. OxBu and OxHex proved cytotoxic and antiproliferative in the nanomolar concentration range and thus exceeded activity of aphidicolin, the relevant model compound, and 5-fluorouracil, the current standard for the therapy of actinic keratosis. Interestingly, the cytotoxicity in normal human keratinocytes with OxHex was clearly less pronounced and even not detectable with OxBu. Moreover, cytotoxicity of OxBu in particular with the colorectal carcinoma cell line HT29 even surmounted cytotoxicity in SCC25, and other tumor cell lines were influenced, too, by both agents. Taken together, OxBu and OxHex may offer a new approach to cancer therapy, given the agents are sufficiently well tolerated in vivo which is to be suspected beside their chemical structure.

As well as for topically used dermatological agents, studies performed according to the rules of evidence-based medicine (EBM) are also needed for cosmetics. Although the concept of evidence-based cosmetics has been only partly developed so far, there are some agents and preparations available that can be considered as evidence-based. In this paper we present data from several studies that claim to have examined and demonstrated the efficacy of cosmetic preparations for the management of solar damage and aging skin as well as lentigo and melanosis according to EBM criteria. Certainly, further controlled studies are needed to cover the main application areas of dermocosmetics. Retinol and antioxidant agents such as vitamin C and coenzymes that positively act via several mechanisms on collagen biosynthesis can be considered evidence-based substances for the management of aging skin. According to the same criteria, the preventive effect of regularly applied dermocosmetic sun screens on the development of actinic keratosis could also be shown. Dermocosmetic sun screens should offer adequate protection against UV-B and UV-A light by combining compatible organic and/or non-organic UV-filters and at the same time be well tolerated. Furthermore, they may contain some additional agents such as antioxidants, DNA repair enzymes, dexpanthenol, glycerin or hamamelis distillate. In the treatment of melanosis, a substantial bleaching effect corresponding to that of 0.1% topical tretinoin can be achieved with 10% all-trans-retinol gel. Preparations containing urea, ammonium lactate or glycerol in different concentrations are considered the best characterized and most effective substances for the care of dry skin. However, the lack of controlled studies confirming the efficacy of dermocosmetic products as well as the superiority of the preparation incorporating the active agent over the corresponding base is a problem yet to be solved. Undoubtedly, the efficacy and the sustainability of the achieved effects have to be examined and proven accordingly to EBM criteria in further active cosmetic agents. Moreover, generally accepted guidelines for the examination of efficacy and tolerability of dermocosmetics have to be developed.

The Toll protein of Drosophila is a transmembrane receptor involved in dorsoventral polarization during embryonic development and recognition of infection. In mammals, Toll-like receptors (TLRs) constitute a novel protein family involved in innate immunity and respond to a wide spectrum of microorganisms, including fungi, bacteria, viruses, and protozoa. Specific agonists for nine of the ten members of the human TLR family have been described to date. TLRs as well as the TLR-associated adaptor molecule MyD88 have been implicated in the recognition of the fungal pathogens Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans and Pneumocystis carinii. Moreover, several pathogen associated molecular patterns (PAMPs) located in the cell wall or cell surface of fungi have been identified as potential ligands. Yeast zymosan activates TLR2/ TLR6 heterodimers, whereas Saccharomyces cerevisiae- and C alhicans-derived mannan seems to be detected by TLR4. Phospholipomannan, present in the cell surface of C. albicans has been shown to be recognized by TLR2, while TLR4 mainly interacts with glucuronoxylomannan, the major capsular polysaccharide of C. neoformans. MyD88 has been implicated in TLR signalling of linear (1-->3)-beta-glucan, and of P-glucan from P carinii. These data point towards the ability of the innate immune system to utilize TLRs that are specific to different types and components of pathogenic fungi. Recent evidence further suggests that TLRs cooperate with other immune receptors involved in fungal recognition and that the selective induction of adaptor proteins finally leads to distinct signalling events upon fungal challenge.

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 7, Issue 11 p. 996-1003 Rosacea Katharina Gauwerky, Katharina GauwerkySearch for more papers by this authorWinfried Klövekorn, Winfried KlövekornSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPercy Lehmann, Percy LehmannSearch for more papers by this authorEva-Maria Meigel, Eva-Maria MeigelSearch for more papers by this authorDieter Reinel, Dieter ReinelSearch for more papers by this authorThomas Ruzicka, Thomas RuzickaSearch for more papers by this authorMartin Schaller, Martin SchallerSearch for more papers by this authorHelmut Schöfer, Helmut SchöferSearch for more papers by this authorJulia Tietze, Julia TietzeSearch for more papers by this author Katharina Gauwerky, Katharina GauwerkySearch for more papers by this authorWinfried Klövekorn, Winfried KlövekornSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPercy Lehmann, Percy LehmannSearch for more papers by this authorEva-Maria Meigel, Eva-Maria MeigelSearch for more papers by this authorDieter Reinel, Dieter ReinelSearch for more papers by this authorThomas Ruzicka, Thomas RuzickaSearch for more papers by this authorMartin Schaller, Martin SchallerSearch for more papers by this authorHelmut Schöfer, Helmut SchöferSearch for more papers by this authorJulia Tietze, Julia TietzeSearch for more papers by this author First published: 22 October 2009 https://doi.org/10.1111/j.1610-0387.2009.07119.xCitations: 5 Dr. Julia Tietze, Dr. Katharina GauwerkyDepartment of Dermatology and AllergyLudwig Maximilian UniversityFrauenlobstraße 9–11D-80337 Munich, GermanyE-mail: Julia.Tietze@med.uni-muenchen.de;Katharina.Gauwerky@med.uni-muenchen.de Section EditorProf. Dr. Hans Christian Korting,München Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume7, Issue11November 2009Pages 996-1003 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 7, Issue 11 p. 996-1003 Rosazea Katharina Gauwerky, Katharina GauwerkySearch for more papers by this authorWinfried Klövekorn, Winfried KlövekornSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPercy Lehmann, Percy LehmannSearch for more papers by this authorEva-Maria Meigel, Eva-Maria MeigelSearch for more papers by this authorDieter Reinel, Dieter ReinelSearch for more papers by this authorThomas Ruzicka, Thomas RuzickaSearch for more papers by this authorMartin Schaller, Martin SchallerSearch for more papers by this authorHelmut Schöfer, Helmut SchöferSearch for more papers by this authorJulia Tietze, Julia TietzeSearch for more papers by this author Katharina Gauwerky, Katharina GauwerkySearch for more papers by this authorWinfried Klövekorn, Winfried KlövekornSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPercy Lehmann, Percy LehmannSearch for more papers by this authorEva-Maria Meigel, Eva-Maria MeigelSearch for more papers by this authorDieter Reinel, Dieter ReinelSearch for more papers by this authorThomas Ruzicka, Thomas RuzickaSearch for more papers by this authorMartin Schaller, Martin SchallerSearch for more papers by this authorHelmut Schöfer, Helmut SchöferSearch for more papers by this authorJulia Tietze, Julia TietzeSearch for more papers by this author First published: 22 October 2009 https://doi.org/10.1111/j.1610-0387.2009.07119_supp.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume7, Issue11November 2009Pages 996-1003 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 7, Issue 1 p. 11-20 Stellenwert von Itraconazol in der Behandlung von Pilzinfektionen der Haut, Nägel und Schleimhäute Hans Christian Korting, Hans Christian Korting Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this authorClaudia Schöllmann, Claudia Schöllmann Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this author Hans Christian Korting, Hans Christian Korting Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this authorClaudia Schöllmann, Claudia Schöllmann Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, MünchenSearch for more papers by this author First published: 24 December 2008 https://doi.org/10.1111/j.1610-0387.2008.06751_supp.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume7, Issue1January 2009Pages 11-20 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 6, Issue 7 p. 593-597 Orale Candidose Dieter Reinel, Dieter ReinelSearch for more papers by this authorAndreas Plettenberg, Andreas PlettenbergSearch for more papers by this authorClaus Seebacher, Claus SeebacherSearch for more papers by this authorDietrich Abeck, Dietrich AbeckSearch for more papers by this authorJochen Brasch, Jochen BraschSearch for more papers by this authorOliver Cornely, Oliver CornelySearch for more papers by this authorIsaak Effendy, Isaak EffendySearch for more papers by this authorGabriele Ginter-Hanselmayer, Gabriele Ginter-HanselmayerSearch for more papers by this authorNorbert Haake, Norbert HaakeSearch for more papers by this authorGudrun Hamm, Gudrun HammSearch for more papers by this authorUta-Christina Hipler, Uta-Christina HiplerSearch for more papers by this authorHerbert Hof, Herbert HofSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPeter Mayser, Peter MayserSearch for more papers by this authorMarkus Ruhnke, Markus RuhnkeSearch for more papers by this authorKurt-Heiner Schlacke, Kurt-Heiner SchlackeSearch for more papers by this authorHans-Jürgen Tietz, Hans-Jürgen TietzSearch for more papers by this author Dieter Reinel, Dieter ReinelSearch for more papers by this authorAndreas Plettenberg, Andreas PlettenbergSearch for more papers by this authorClaus Seebacher, Claus SeebacherSearch for more papers by this authorDietrich Abeck, Dietrich AbeckSearch for more papers by this authorJochen Brasch, Jochen BraschSearch for more papers by this authorOliver Cornely, Oliver CornelySearch for more papers by this authorIsaak Effendy, Isaak EffendySearch for more papers by this authorGabriele Ginter-Hanselmayer, Gabriele Ginter-HanselmayerSearch for more papers by this authorNorbert Haake, Norbert HaakeSearch for more papers by this authorGudrun Hamm, Gudrun HammSearch for more papers by this authorUta-Christina Hipler, Uta-Christina HiplerSearch for more papers by this authorHerbert Hof, Herbert HofSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPeter Mayser, Peter MayserSearch for more papers by this authorMarkus Ruhnke, Markus RuhnkeSearch for more papers by this authorKurt-Heiner Schlacke, Kurt-Heiner SchlackeSearch for more papers by this authorHans-Jürgen Tietz, Hans-Jürgen TietzSearch for more papers by this author First published: 16 July 2008 https://doi.org/10.1111/j.1610-0387.2008.06801.xCitations: 23 Leitlinie der Deutschen Dermatologischen Gesellschaft und der Deutschsprachigen Mykologischen Gesellschaft AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume6, Issue7July 2008Pages 593-597 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 5, Issue 1 Onychomykose Claus Seebacher, Claus SeebacherSearch for more papers by this authorJochen Brasch, Jochen BraschSearch for more papers by this authorDietrich Abeck, Dietrich AbeckSearch for more papers by this authorOliver Cornely, Oliver CornelySearch for more papers by this authorIsaak Effendy, Isaak EffendySearch for more papers by this authorGabriele Ginter-Hanselmayer, Gabriele Ginter-HanselmayerSearch for more papers by this authorNorbert Haake, Norbert HaakeSearch for more papers by this authorGudrun Hamm, Gudrun HammSearch for more papers by this authorUta-Christina Hipler, Uta-Christina HiplerSearch for more papers by this authorHerbert Hof, Herbert HofSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPeter Mayser, Peter MayserSearch for more papers by this authorMarkus Ruhnke, Markus RuhnkeSearch for more papers by this authorKurt-Heiner Schlacke, Kurt-Heiner SchlackeSearch for more papers by this authorHans-Jörgen Tietz, Hans-Jörgen TietzSearch for more papers by this author Claus Seebacher, Claus SeebacherSearch for more papers by this authorJochen Brasch, Jochen BraschSearch for more papers by this authorDietrich Abeck, Dietrich AbeckSearch for more papers by this authorOliver Cornely, Oliver CornelySearch for more papers by this authorIsaak Effendy, Isaak EffendySearch for more papers by this authorGabriele Ginter-Hanselmayer, Gabriele Ginter-HanselmayerSearch for more papers by this authorNorbert Haake, Norbert HaakeSearch for more papers by this authorGudrun Hamm, Gudrun HammSearch for more papers by this authorUta-Christina Hipler, Uta-Christina HiplerSearch for more papers by this authorHerbert Hof, Herbert HofSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPeter Mayser, Peter MayserSearch for more papers by this authorMarkus Ruhnke, Markus RuhnkeSearch for more papers by this authorKurt-Heiner Schlacke, Kurt-Heiner SchlackeSearch for more papers by this authorHans-Jörgen Tietz, Hans-Jörgen TietzSearch for more papers by this author First published: 03 January 2007 https://doi.org/10.1111/j.1610-0387.2007.06134_supp.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume5, Issue1January 2007 RelatedInformation

A new, single-application formulation containing terbinafine has recently been approved for the treatment of athlete’s foot. An expert panel of dermatologists was convened to provide guidance on the important attributes of this new film-forming solution (FFS), how best to inform potential users on these benefits and how to ensure appropriate use. A consumer survey about tinea pedis revealed an average disease duration of 7 years, an average of four recurrences per year, patient concerns about itching and foot odor, but a poor level of patient knowledge on the cause of tinea pedis and available treatments. A review of the clinical trial data that led to the successful registration of the FFS demonstrated that treatment was both effective and well tolerated. The panel also considered data supporting the treatment of the entire lateral and undersurface areas of both feet, rather than lesions that are just symptomatic, usually the interdigital spaces, as previously recommended, and discussed guidelines for use of the new formulation. Discussion focused on the value of single-dose treatment in addressing noncompliance with treatment for the correct duration, guidelines for treatment of both feet and the need for an educational program on the FFS for dermatologists and pharmacists, and appropriate instructions for patients. The panel concluded that new single-dose therapy with terbinafine FFS presents a novel treatment opportunity owing to its simplicity of application. This provides an opportunity to develop new ways of increasing interaction between dermatologists, pharmacists, scientific/news media and patients, so that there is full understanding of the value of the new treatment.

The family of secreted aspartic proteinases (Sap) encoded by 10 SAP genes is an important virulence factor during Candida albicans (C. albicans) infections. Antagonists to Saps could be envisioned to help prevent or treat candidosis in immunocompromised patients. The knowledge of several Sap structures is crucial for inhibitor design; only the structure of Sap2 is known. We report the 1.9 and 2.2 Å resolution X‐ray crystal structures of Sap3 in a stable complex with pepstatin A and in the absence of an inhibitor, shedding further light on the enzyme inhibitor binding. Inhibitor binding causes active site closure by the movement of a flap segment. Comparison of the structures of Sap3 and Sap2 identifies elements responsible for the specificity of each isoenzyme. Proteins 2007. © 2007 Wiley‐Liss, Inc.

Summary Background: Hydroxyethyl starch (HES) is widely used as a plasma substitute for improving microcirculation. A major side effect of HES is severe pruritus caused by HES deposits in the skin. Since specific changes are difficult to see in paraffin sections, electron microscopy is the golden standard technique in the diagnosis of HES‐induced skin disease. Our aim was to compare electron microscopic search for HES deposits with other techniques. Patients and Methods: During the last ten years, we biopsied 21 patients suspected of having HES‐induced pruritus. We compared conventional microscopy with hematoxylin & eosin and toluidine blue‐stained paraffin sections, toluidine blue‐stained glycide ether‐embedded, semithin sections and transmission electron microscopy. Results: In 9 patients specific HES deposits could be found by evaluating toluidine blue stained semithin sections by light microscopy alone. In 6 of these cases electron microscopy was also done and confirmed the findings. In contrast, no specific findings due to HES deposits could be detected by conventional histology. Conclusions: If specific HES deposits are found in toluidine blue‐stained, glycide ether‐embedded semithin sections, electron microscopy is not required.

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 4, Issue 7 p. 591-596 Candidose der Haut Claus Seebacher, Claus SeebacherSearch for more papers by this authorDietrich Abeck, Dietrich AbeckSearch for more papers by this authorJochen Brasch, Jochen BraschSearch for more papers by this authorIsaak Effendy, Isaak EffendySearch for more papers by this authorGabriele Ginter-Hanselmayer, Gabriele Ginter-HanselmayerSearch for more papers by this authorNorbert Haake, Norbert HaakeSearch for more papers by this authorGudrun Hamm, Gudrun HammSearch for more papers by this authorHerbert Hof, Herbert HofSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPeter Mayser, Peter MayserSearch for more papers by this authorMarkus Ruhnke, Markus RuhnkeSearch for more papers by this authorKurt-Heiner Schlacke, Kurt-Heiner SchlackeSearch for more papers by this authorHans-Jürgen Tietz, Hans-Jürgen TietzSearch for more papers by this author Claus Seebacher, Claus SeebacherSearch for more papers by this authorDietrich Abeck, Dietrich AbeckSearch for more papers by this authorJochen Brasch, Jochen BraschSearch for more papers by this authorIsaak Effendy, Isaak EffendySearch for more papers by this authorGabriele Ginter-Hanselmayer, Gabriele Ginter-HanselmayerSearch for more papers by this authorNorbert Haake, Norbert HaakeSearch for more papers by this authorGudrun Hamm, Gudrun HammSearch for more papers by this authorHerbert Hof, Herbert HofSearch for more papers by this authorHans Christian Korting, Hans Christian KortingSearch for more papers by this authorPeter Mayser, Peter MayserSearch for more papers by this authorMarkus Ruhnke, Markus RuhnkeSearch for more papers by this authorKurt-Heiner Schlacke, Kurt-Heiner SchlackeSearch for more papers by this authorHans-Jürgen Tietz, Hans-Jürgen TietzSearch for more papers by this author First published: 19 June 2006 https://doi.org/10.1111/j.1610-0387.2006.05888.xCitations: 11AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume4, Issue7July 2006Pages 591-596 RelatedInformation