The Anatomical RecordVolume 66, Issue 2 p. 201-215 Article Studies on the physiology of lactation. V. The induction of lactation in depancreatized dogs† Warren O. Nelson, Warren O. Nelson Departments of Anatomy and Physiology, Yale University School of MedicineSearch for more papers by this authorHarold E. Himwich, Harold E. Himwich Departments of Anatomy and Physiology, Yale University School of MedicineSearch for more papers by this authorJ. F. Fazekas, J. F. Fazekas Departments of Anatomy and Physiology, Yale University School of MedicineSearch for more papers by this author Warren O. Nelson, Warren O. Nelson Departments of Anatomy and Physiology, Yale University School of MedicineSearch for more papers by this authorHarold E. Himwich, Harold E. Himwich Departments of Anatomy and Physiology, Yale University School of MedicineSearch for more papers by this authorJ. F. Fazekas, J. F. Fazekas Departments of Anatomy and Physiology, Yale University School of MedicineSearch for more papers by this author First published: September 1936 https://doi.org/10.1002/ar.1090660206Citations: 4 † Aided by grants from the National Research Council, Committe for Research in Problems of Sex, and from the Anna Fuller Fund. Grants administered by Dr. Edgar Allen. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume66, Issue2September 1936Pages 201-215 RelatedInformation

ArticleMETABOLIC ASPECTS OF THYROID-ADRENAL INTERRELATIONSHIPS. B. Barker, J. F. Fazikas, and H. E. HimwichS. B. BarkerFrom the Laboratory of Physiology, Yale University School of Medicine, J. F. FazikasFrom the Laboratory of Physiology, Yale University School of Medicine, and H. E. HimwichFrom the Laboratory of Physiology, Yale University School of MedicinePublished Online:31 Mar 1936https://doi.org/10.1152/ajplegacy.1936.115.2.415MoreSectionsPDF (460 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 115Issue 2March 1936Pages 415-418 Copyright & PermissionsCopyright © 1936 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1936.115.2.415History Received 16 January 1936 Published online 31 March 1936 Published in print 31 March 1936 Metrics

The effects of sodium deprivation were observed in 5 dogs over periods varying from 4 to 7 days. Sodium loss produces a condition similar to that of adrenal insufficiency, namely, increased concentration of the blood and a retention of blood urea, loss of serum chlorides and a creatinuria.

We are reporting experiments elsewhere on the effects of cysteine and cystine on the metabolism of rats (Goldfarb, Fazekas, Himwich). The present communication is a report of further experiments on isolated brain tissue. The observations were limited to the effects of cysteine, since cystine was soluble in solutions too alkaline or acid to support respiration. In all experiments the tissue was suspended in a phosphate medium buffered at pH 7.4 with lactate as a substrate. The tissues were inserted in the Warburg respirometer and one-half hour elapsed, the time required for equilibration, before observations were begun. The data disclose that the O2 consumption of the brain tissue treated with cysteine exhibits a diphasic response. During the first 30 to 45 minutes there is a marked stimulation which is followed by a profound depression in the later periods. Cysteine, moreover, retains an early stimulatory effect on O2 consumption despite the presence of cyanide. In order to obtain further information as to the character of the increased O2 consumption, a group of observations was made on the R.Q. after the addition of cysteine hydrochloride in a concentration of 0.01 M. In most instances the R.Q. of unwashed, minced brain tissue is approximately 0.9, (Himwich, Fazekas, Barker, Hurlburt) and in these studies the addition of cysteine resulted in a depression of the quotient. In 8 experiments they were found to be 0.50, 0.65, 0.65, 0.54, 0.59, 0.52, 0.30, and 0.83. The presence of the sulphydryl group had obviously caused a consumption of O2 without the simultaneous production of CO2.

ArticleTHE CARBOHYDRATE METABOLISM OF THE HEART DURING PANCREAS DIABETESH. E. Himwich, W. Goldfarb, and J. F. FazikasH. E. HimwichFrom the Laboratory of Physiology, Yale University School of Medicine, W. GoldfarbFrom the Laboratory of Physiology, Yale University School of Medicine, and J. F. FazikasFrom the Laboratory of Physiology, Yale University School of MedicinePublished Online:31 Dec 1935https://doi.org/10.1152/ajplegacy.1935.114.2.273MoreSectionsPDF (658 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 114Issue 2December 1935Pages 273-277 Copyright & PermissionsCopyright © 1935 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1935.114.2.273History Received 2 July 1935 Published online 31 December 1935 Published in print 31 December 1935 Metrics

Back to table of contents Previous article Next article ARTICLENo AccessA COMPARATIVE STUDY OF SOME OF THE CHANGES PRODUCED BY VARIOUS TYPES OF DRUGS IN SCHIZOPHRENIC PATIENTSE. F. Gildea, H. E. Himwich, O. E. Hubbard, and J. F. FazikasE. F. Gildea, H. E. Himwich, O. E. Hubbard, and J. F. FazikasPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.91.6.1289AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail PDFThis content is only available as a PDF. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited ByA historical perspective on the role of state hospitals viewed from the era of the "revolving door"1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 11PSYCHIATRIC USES OF INTRAVENOUS SODIUM AMYTAL1 April 2006 | American Journal of Psychiatry, Vol. 99, No. 3 Volume 91Issue 6 May 1935Pages 1289-1309 Metrics PDF download History Published online 1 April 2006 Published in print 1 May 1935

ArticleTHE RESPIRATORY QUOTIENT OF MUSCLE OF DEPANCREATIZED DOGSH. E. Himwich, W. Goldfarb, N. Rakeiten, L. H. Nahum, and D. DuBoisH. E. HimwichFrom the Laboratory of Physiology, Yale University School of Medicine, W. GoldfarbFrom the Laboratory of Physiology, Yale University School of Medicine, N. RakeitenFrom the Laboratory of Physiology, Yale University School of Medicine, L. H. NahumFrom the Laboratory of Physiology, Yale University School of Medicine, and D. DuBoisFrom the Laboratory of Physiology, Yale University School of MedicinePublished Online:30 Nov 1934https://doi.org/10.1152/ajplegacy.1934.110.2.352MoreSectionsPDF (651 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 110Issue 2November 1934Pages 352-356 Copyright & PermissionsCopyright © 1934 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1934.110.2.352History Received 19 August 1934 Published online 30 November 1934 Published in print 30 November 1934 Metrics

ArticleA STUDY OF SUBCUTANEOUS ABSORPTION IN THE ADRENALECTOMIZED RATSamuel B. Barker, Joseph F. Fazikas, and Harold E. HimwichSamuel B. BarkerFrom the Laboratory of Physiology, Yale University School of Medicine, Joseph F. FazikasFrom the Laboratory of Physiology, Yale University School of Medicine, and Harold E. HimwichFrom the Laboratory of Physiology, Yale University School of MedicinePublished Online:31 Oct 1934https://doi.org/10.1152/ajplegacy.1934.110.1.153MoreSectionsPDF (733 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 110Issue 1October 1934Pages 153-158 Copyright & PermissionsCopyright © 1934 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1934.110.1.153History Received 4 July 1934 Published online 31 October 1934 Published in print 31 October 1934 Metrics

ArticleCHANGES OF THE CARBOHYDRATE METABOLISM OF THE HEART FOLLOWING CORONARY OCCLUSIONH. E. Himwich, W. Goldfarb, and L. H. NahumH. E. HimwichFrom the Laboratory of Physiology, Yale University School of Medicine, W. GoldfarbFrom the Laboratory of Physiology, Yale University School of Medicine, and L. H. NahumFrom the Laboratory of Physiology, Yale University School of MedicinePublished Online:31 Aug 1934https://doi.org/10.1152/ajplegacy.1934.109.3.403MoreSectionsPDF (701 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 109Issue 3August 1934Pages 403-408 Copyright & PermissionsCopyright © 1934 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1934.109.3.403History Received 20 May 1934 Published online 31 August 1934 Published in print 31 August 1934 Metrics

ArticleTHE LIPID COMPONENTS OF THE LYMPH OF THE THORACIC DUCT OF THE DOGSusan H. Brockett, Mary A. Spiers, and Harold E. HimwichSusan H. BrockettFrom the Laboratory of Physiology, Yale University School of Medicine, Mary A. SpiersFrom the Laboratory of Physiology, Yale University School of Medicine, and Harold E. HimwichFrom the Laboratory of Physiology, Yale University School of MedicinePublished Online:30 Nov 1934https://doi.org/10.1152/ajplegacy.1934.110.2.342MoreSectionsPDF (809 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 110Issue 2November 1934Pages 342-347 Copyright & PermissionsCopyright © 1934 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1934.110.2.342History Received 13 August 1934 Published online 30 November 1934 Published in print 30 November 1934 Metrics

ArticleDIABETIC HYPERPYREXIAH. E. Himwich, J. F. Fazikas, L. H. Nahum, D. DuBois, L. Greenburg, and A. GilmanH. E. HimwichFrom the Departments of Physiology, Public Health, and Pharmacology and Toxicology, Yale University School of Medicine, J. F. FazikasFrom the Departments of Physiology, Public Health, and Pharmacology and Toxicology, Yale University School of Medicine, L. H. NahumFrom the Departments of Physiology, Public Health, and Pharmacology and Toxicology, Yale University School of Medicine, D. DuBoisFrom the Departments of Physiology, Public Health, and Pharmacology and Toxicology, Yale University School of Medicine, L. GreenburgFrom the Departments of Physiology, Public Health, and Pharmacology and Toxicology, Yale University School of Medicine, and A. GilmanFrom the Departments of Physiology, Public Health, and Pharmacology and Toxicology, Yale University School of MedicinePublished Online:31 Oct 1934https://doi.org/10.1152/ajplegacy.1934.110.1.19MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 110Issue 1October 1934Pages 19-27 Copyright & PermissionsCopyright © 1934 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1934.110.1.19History Received 20 June 1934 Published online 31 October 1934 Published in print 31 October 1934 Metrics

Amytal, nembutal, luminal, Dial-Ciba and urethane in narcotic doses have a decided effect on the acid-base equilibrium and produce a definite acidosis. The effects of amytal, nembutal and luminal on the blood constituents studied may be grouped together. With the exception of its effect on pH Dial-Ciba with its barbituric acid and urethane components has a different action. The effect on CO2 content is the result of both its components while the urethane action predominates on the other blood constituents. The change in O2 and CO2 content and capacity and blood sugar are given in table 4 together with possible causes for these changes.