Purpose Moyamoya disease (MMD) occurs predominantly in Korean and Japanese women. The aim of this study was to investigate clinical features and pregnancy outcomes in women with MMD. Materials and Methods We conducted a retrospective chart review of women with MMD who visited our Department of Obstetrics and Gynecology between January 2005 and October 2013. For all study subjects, clinical features, demographic characteristics, and perinatal outcomes were recorded. Results We identified 28 pregnancies in 22 patients who had been diagnosed with MMD. The mean maternal age at delivery was 31.9±3.5 years old. The mean gestational age at delivery was 38.0±0.9 weeks. Among the 28 pregnancies, 25 (92.5%) underwent cesarean section; 19 (76.0%) of them were performed under regional anesthesia and six (24.0%) under general anesthesia. The mean newborn weight was 3233.7±348.2 g. The 5-minute Apgar score in 85% of the newborns was higher than 8, with no other apparent complications. During the puerperal period, transient ischemic attack symptom or seizure occurred in 4 cases, although patients recovered within a few days. Conclusion For pregnant women with MMD, it is important to control blood pressure and prevent hyperventilation during the intrapartum period, and the best methods of delivery and anesthesia should be considered to avoid unfavorable sequelae. Additionally, a multidisciplinary approach (i.e., neurosurgery) is necessary to constantly manage underlying diseases.

목적: Moyamoya disease (MMD) occurs predominantly in Korean and Japanese women. The aim of this study is to investigate the clinical feature and pregnancy outcome in women with MMD. 방법: We conducted a retrospective chart review of women with MMD who visited our department of obstetrics and gynecology between January 2005 and October 2013. For all study subjects, clinical features, demographic characteristics and perinatal outcomes were recorded. 결과: 28 pregnancies in 22 patients who had been diagnosed with MMD were identified. The mean maternal age at delivery was 31.9 ± 3.5 years old. The mean gestational age at delivery was 38.0 ± 0.9 weeks. Among the 28 pregnancies, 25 (92.5%) underwent cesarean section. 19 (76.0%) of them were performed under regional anesthesia and 6 (24.0%) under general anesthesia. The mean newborn weight was 3233.7 ± 348.2 g. The 5 minute Apgar score in 85 % of newborns was higher than 8, evidently showing no other complication. During the puerperal period, transient ischemic attack symptom or seizure occurred in 4 cases but patients were soon recovered within a few days. 결론: For pregnant women with MMD, it is important to control blood pressure and prevent hyperventilation during the intrapartum period, and the best methods of delivery and anesthesia should be considered to avoid unfavorable sequelae. Additionally, a multidisciplinary approach (i.e., neurosurgery) is necessary to constantly manage underlying diseases.

Results The two groups had no difference with cardiovascular disease, history of cardiovascular disease, age, obesity, smoking, alcohol, hypertension, dyslipidemia, excluding diabetes. In the univariate logistic regression analysis, diabetes was associated with prevalence of overactive bladder than stress urinary incontinence. In the multiple logistic regression analysis, there was no factor which had influence on the status of urinary incontinence.