Polymorphic Eruption of Pregnancy, also known as Pruritic Urticarial Papules and Plaques of Pregnancy, is a common benign dermatosis of pregnancy related to stretching of the abdominal wall, frequent misdiagnosed with an allergic reaction. It usually appears during late third trimester and resolves within few days or weeks or after deliver.

European Journal of PainVolume 13, Issue S1 p. S112a-S112 371 EFFECT OF THE INJECTION OF CRPS IgG SERUM FRACTION IN MICE A. Goebel, A. Goebel Liverpool University and the Walton Centre NHS Trust, Liverpool, United KingdomSearch for more papers by this authorC.M. Cendan, C.M. Cendan Molecular Nociception Group, UCL, London, United KingdomSearch for more papers by this authorB. Abrahmson, B. Abrahmson Molecular Nociception Group, UCL, London, United KingdomSearch for more papers by this authorR. Deacon, R. Deacon Experimental Psychology, Oxford University, Oxford, United KingdomSearch for more papers by this authorA. Lewis, A. Lewis Experimental Psychology, Oxford University, Oxford, United KingdomSearch for more papers by this authorL. Clover, L. Clover Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this authorI. Leite, I. Leite Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this authorL. Zhang, L. Zhang Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this authorA. Vincent, A. Vincent Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this author A. Goebel, A. Goebel Liverpool University and the Walton Centre NHS Trust, Liverpool, United KingdomSearch for more papers by this authorC.M. Cendan, C.M. Cendan Molecular Nociception Group, UCL, London, United KingdomSearch for more papers by this authorB. Abrahmson, B. Abrahmson Molecular Nociception Group, UCL, London, United KingdomSearch for more papers by this authorR. Deacon, R. Deacon Experimental Psychology, Oxford University, Oxford, United KingdomSearch for more papers by this authorA. Lewis, A. Lewis Experimental Psychology, Oxford University, Oxford, United KingdomSearch for more papers by this authorL. Clover, L. Clover Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this authorI. Leite, I. Leite Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this authorL. Zhang, L. Zhang Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this authorA. Vincent, A. Vincent Department of Neuroimmunology, Oxford University, Oxford, United KingdomSearch for more papers by this author First published: 12 January 2012 https://doi.org/10.1016/S1090-3801(09)60374-8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume13, IssueS1September 2009Pages S112a-S112 RelatedInformation

Background: There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease. Methods: Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability. Results: Cross-sectional EDSS measurements made after the first year were representative of overall disease severity. The MSSS was more powerful than the other methods the authors tested for detecting different rates of disease progression. Conclusion: The Multiple Sclerosis Severity Score (MSSS) is a powerful method for comparing disease progression using single assessment data. The Global MSSS can be used as a reference table for future disability comparisons. While useful for comparing groups of patients, disease fluctuation precludes its use as a predictor of future disability in an individual.

Background:There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease. Methods:Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability. Results:Cross-sectional EDSS measurements made after the first year were representative of overall disease severity. The MSSS was more powerful than the other methods the authors tested for detecting different rates of disease progression. Conclusion:The Multiple Sclerosis Severity Score (MSSS) is a powerful method for comparing disease progression using single assessment data. The Global MSSS can be used as a reference table for future disability comparisons. While useful for comparing groups of patients, disease fluctuation precludes its use as a predictor of future disability in an individual.

We have completed a survey of European neurological practice concerning cerebral vasculitis. Twenty‐nine respondents from 15 countries provided information concerning the diagnosis and management. The results confirmed the anticipated low frequency of the disease, but also illustrated the power of any putative collaborative effort. Interestingly, there was a wide variation in clinical practice, in particular concerning the perceived importance of cerebral angiography as a diagnostic test and the very common use of steroids as first‐line treatment, rather than more potent immunosuppressive agents. This variation is probably to be explained at least, in part, by the absence of any firm evidence base to inform clinical practice. A European collaborative effort – in which there has emerged considerable interest – offers a realistic opportunity to generate sound clinical evidence and thence scientifically robust practical guidelines.

Pre-eclampsia is a disease that can affect several organs and systems. Neurologic repercussions are particularly feared, provoking, among other manifestations, seizures and blindness. Imaging techniques are available to elucidate the pathogenesis of this complication, also allowing us to diagnose other brain lesions: CT, MRI and transcranial Doppler. The authors present some aspects of imaging techniques related to the neurologic complications in preeclampsia/eclampsia.

Pre-eclampsia is a disease that can affect several organs and systems. Neurologic repercussions are particularly feared, provoking, among other manifestations, seizures and blindness. Imaging techniques are available to elucidate the pathogenesis of this complication, also allowing us to diagnose other brain lesions: CT, MRI and transcranial Doppler. The authors present some aspects of imaging techniques related to the neurologic complications in preeclampsia/eclampsia.

We reviewed 44 cases of ischemia and infarction of the spinal cord at two university hospitals.Three patients experienced transient ischemic attacks. Etiologies of completed strokes were diverse and included rupture and surgical repair of aortic aneurysms, aortic dissection, aortic rupture and thrombosis, global ischemia, anterior spinal artery embolism, repair and thrombosis of spinal arteriovenous malformations, hematomyelia, epidural hematoma, cervical osteophytosis, celiac plexus block, systemic lupus erythematosus, coagulopathy, and decompression sickness. Motor function improved in 12 patients, was substantial in only one, and occurred largely within the first 2 to 4 weeks. Favorable ambulatory outcome correlated with improving neurologic examinations and relatively preserved strength in hip abductors and knee extensors. More extensive deficits without initial improvement portended a more severe prognosis. Autonomic dysfunction, pain, paresthesia, and depression were common and impeded recovery in some patients. The mean level of deficit was at T-8 and in cases of global ischemia was at T-9, which leads us to dispute the classical view of a midthoracic watershed zone of ischemic vulnerability near T-4. NEUROLOGY 1996;47: 321-330

Transient cortical blindness in the postpartum period is a rare neurological event. Usually bilateral occipital involvement appears as a manifestation of pre‐eclampsia or eclampsia (Royburt et al., 1991; Cunningham and Lindheimer, 1992). We report a case of isolated cortical blindness as the only manifestation of pregnancy‐induced hypertension in the postpartum period.