Intrahepatic cholestasis of pregnancy (ICP) is a hepatobiliary disorder characterized by elevated bile acid levels and liver dysfunction and usually occurs in the third trimester. Although the ICP has been associated with various fetal complications, its effects on maternal coagulation are poorly understood. Recent studies suggest that ICP may both cause hypercoagulability and increase bleeding tendency by impairing the synthesis of clotting factors. The aim of this study was to evaluate the relationships between ICP and coagulation parameters and to examine their potential clinical implications. This retrospective case‒control study included 175 pregnant women with ICP and 162 healthy women matched for gestational age. Demographic, biochemical and hematologic parameters were analyzed. The prothrombin time (PT), activated partial thromboplastin time (aPTT), international normalized ratio (INR) and fibrinogen levels were evaluated. Fibrinogen levels were significantly greater in the ICP group (p < 0.01), but PT, aPTT and INR values were not significantly different (p > 0.05). In the postpartum period, 2 cases of venous thromboembolism (VTE) were observed in the ICP group, whereas no cases of VTE were observed in the control group. Furthermore, the mean gestational age at delivery was significantly lower in ICP patients (253.75 ± 15.53 days vs. 271.43 ± 10.26 days, p < 0.01). Fetal complication rates were also significantly higher; the most common complications were fetal distress (7.4

Objectives: Postpartum hemorrhage (PPH) is a significant global health risk for mothers. This study investigated the predictive capacity of the systemic immune inflammatory index (SII) to assess the risk of PPH. The SII, which is predicated on cell types of integral to inflammatory processes, correlates with high values of increased inflammatory activity and potentially adverse prognoses. Material and methods: This retrospective cohort study included female patients aged 15–49 diagnosed with PPH who continued to bleed post-treatment, received transfusions of four or more units of erythrocyte suspension, or underwent laparotomy/re-laparotomy. Results : The study found that Hemoglobin, hematocrit, platelet, and SII values were significantly lower, and lymphocyte counts were elevated in the PPH group. Both univariate and multivariate analyses identified hemoglobin and SII levels as significant determinants of PPH. An SII cutoff value of 915 proved to be an effective predictor of PPH. In subjects with an SII ≥ 915, leukocyte, platelet, and neutrophil values were higher, and lymphocyte counts were lower. Furthermore, the rates of PPH and Intensive Care Unit admissions increased in this cohort. Conclusions: The findings suggest that the SII is a potentially significant marker for PPH risk prediction. Elevated SII levels beyond the threshold of 915 were associated with heightened PPH risk of PPH.

This study aimed to evaluate the prevalence of von Willebrand disease (VWD) among women presenting with menorrhagia and to assess the diagnostic utility of the VWD simple screening tool. A prospective cohort study was conducted involving 70 women, aged 18–48 years, who presented to gynecology clinics with complaints of menorrhagia. Patients were administered an 8-question screening tool, routine tests and underwent further testing for von Willebrand factor antigen (VWF:Ag) and ristocetin cofactor activity (VWF:RCo). Hematologic and coagulation parameters, including hemoglobin, ferritin, activated partial thromboplastin time and prothrombin time were compared between the groups. Of the 70 patients, 22 (31%) were prediagnosed with VWD based on low VWF:Ag and VWF:RCo levels. The VWD group had a higher body mass index (31.19±3.74 vs. 28.20±5.36 kg/m², p<0.05), higher parity (4 vs. 3, p<0.05), and slightly elevated activated partial thromboplastin time levels (26.9 vs. 25.5 seconds, p<0.05) compared to the control group. Hemoglobin, ferritin, and other hematologic parameters were similar between the groups. Using the method applied in this study, 31% of patients with menorrhagia were suspected to have von Willebrand disease, a higher prevalence than reported in other studies. While the VWD simple screening tool was effective in identifying patients with menorrhagia, it fell short in accurately distinguishing those with VWD. Larger prospective studies are needed to enhance the diagnosis of VWD in menorrhagia patients and to better determine its true prevalence.

Objective:Although there are several guidelines in the literature on "recurrent abortion", there is no comprehensive guideline on "threatened abortion". The overall purpose of this guideline is to provide healthcare providers with the best available evidence for examination and treatment of pregnant women with threatened abortion. Materials and Methods:The scope of the guideline and the first version of the questions were prepared by the Perinatology and High Risk Pregnancies Association (PERİDER) guideline development group in January 2024. Meetings were held to discuss key questions and redefine them. A final list of 8 key questions was created. Keywords were defined for each question and ranked in order of importance and used in searches for all English-language publications in PubMed/Medline and Cochrane libraries. These databases were thoroughly scanned for publications that were published until February 1, 2024. Literature reviews were conducted as an iterative process. In the first step, systematic reviews and meta-analyses were collected. If no results were found, the research was expanded to randomized controlled trials and then to cohort studies and case reports, following the hierarchy of evidence levels. Results:This guideline was presented to the board of directors of the Turkish Gynecology and Obstetrics Society (TJOD). With their suggestions, guideline was finalized, and it was decided to be published as a joint guideline of PERİDER-TJOD. Conclusion:This guideline provides an overview of threatened abortion and the recommended treatments. In addition, by recognizing the deficiencies in the literature, suggestions were made regarding research that could help clinicians' decisions in the future.

This study aimed to investigate the prenatal features, genetic findings, and perinatal outcomes of fetuses with congenital anomalies of the kidney and urinary tract (CAKUT), with a particular focus on associations with additional structural or chromosomal abnormalities. A retrospective cohort analysis was conducted on 277 fetuses diagnosed with CAKUT between December 2020 and December 2024 at a tertiary center. Data on anomaly subtypes, associated findings, genetic testing, pregnancy outcomes, and postnatal follow-up were evaluated. Logistic regression was used to identify predictors of termination. Urinary tract dilatation was the most frequent anomaly (28.2

Background: Cesarean hysterectomy is a common approach to managing placenta accreta spectrum (PAS); however, the morbidities related to cesarean hysterectomy are not yet fully understood. This study aimed to investigate urinary incontinence (UI) symptoms and sexual function in patients who underwent hysterectomy due to PAS. Methods: This prospective cohort study was conducted at Basaksehir Cam and Sakura City Hospital in Istanbul, Turkey. The study group included 51 patients who had a cesarean hysterectomy due to PAS and 51 patients in the control group who underwent a cesarean section (CS) at term. Patients in both groups were evaluated 6 to 12 months after surgery. The patients completed the International Consultation on Incontinence Questionnaire for Female Lower Urinary Tract Symptoms Modules (ICIQ-FLUTS) for UI symptoms and the Female Sexual Function Index (FSFI). The PAS group was further divided into patients with and without bladder invasion of the placenta. Results: The ICIQ-FLUTS total score, as well as the filling, voiding, and incontinence subdomain scores, and post-void residual urine volume, were statistically significantly higher in the PAS group than in the control group (p < 0.05). The FSFI total score and the subdomain scores for arousal, lubrication, orgasm, satisfaction, and pain were statistically significantly lower in the PAS group than in the control group (p < 0.05). Subgroup analysis of the PAS group showed no statistically significant difference in UI and sexual function between hysterectomized patients with and without placental invasion of the bladder. Conclusions: Patients with PAS who undergo cesarean hysterectomy have a higher incidence of UI and impaired sexual function postoperatively compared to patients who undergo ordinary CS, regardless of bladder invasion.

BACKGROUND:To evaluate the feasibility and safety of performing myomectomy during cesarean delivery using a novel bleeding-reducing suture technique. METHODS:This retrospective cohort study included pregnant women with intramural uterine fibroids. A total of 120 patients were divided into two groups: Group A consisted of women who underwent myomectomy during cesarean section between January 2020 and June 2024, and Group B included women who underwent cesarean section alone without myomectomy. The following data were obtained from hospital records and compared between the groups: maternal age, gravidity, parity, myoma size, gestational age at time, preoperative and postoperative hemoglobin (Hb) levels, need for blood transfusion, hospital stay, and duration of surgery. The primary outcome of the study was the change in Hb levels before and after the operation. RESULTS:The demographic and laboratory characteristics of 120 pregnant women with intramural leiomyomas who underwent either cesarean myomectomy or cesarean section alone were analyzed. Of these, 60 underwent cesarean section alone, while 60 underwent cesarean section with myomectomy. No statistically significant difference was found between the two groups in terms of preoperative Hb, postoperative 24-hour Hb, or Hb decrease (p = .240, p = .270, and p = .420, respectively). Similarly, there was no significant difference in operation duration (p = .160). A weak but statistically significant negative correlation was observed between myoma size and gestational age at delivery (r = -0.21, p = .0009). No statistically significant correlations were found between myoma size and either operation time or hospital stay. CONCLUSION:Cesarean myomectomy appears to be a feasible and safe option when performed using the bleeding-reducing uterine isthmic circumferential suture technique. However, further multicenter studies with larger sample sizes are required to confirm these findings before recommending cesarean myomectomy as a routine approach.

Fetal intra-abdominal cystic lesions are relatively common. The morphological assessment of the cyst, determination of the fetal sex, and evaluation of its relationship with adjacent structures can guide the differential diagnosis. The aims of this study were to evaluate the diagnostic accuracy of ultrasound in detecting fetal intra-abdominal cysts and to develop a predictive model for spontaneous regression or persistence. We retrospectively reviewed 61 fetuses with intra-abdominal cystic lesions between October 2020 and November 2024. Maternal-fetal characteristics, ultrasonographic features of cystic lesions, and postnatal outcomes were collected. A total of 61 fetuses with intra-abdominal cysts were analyzed. Spontaneous regression occurred in 15 cases (24.6%) during the prenatal period, while 46 (75.4%) persisted postnatally. Mean cyst size was 24.1 mm (+/– 11.2) in the regression group and 40 mm (– 16.5) in the persistent group. Cysts that regressed were diagnosed at a median of 25 weeks, whereas persistent cases were diagnosed at 30 weeks. In univariate logistic regression analyses, gestational age at diagnosis and initial cyst diameter were identified as significant predictors of spontaneous prenatal regression (p=0.006, 0.003, respectively). Prenatal US is an effective tool to accurately diagnose fetal intra-abdominal cysts. The combination of a lower gestational age at diagnosis and a smaller initial cyst diameter is associated with a higher likelihood of spontaneous prenatal regression. An evaluation based on gestational age at diagnosis and ultrasound characteristics with a primary focus on the largest diameter of the cystic lesions may help to guide parental counseling.

Objectives: In the neonatal period, 25% of cases with critical congenital heart disease (CCHD) require surgical or interventional palliative and corrective procedures. Prenatal diagnosis and timely intervention can positively impact neonatal mortality and morbidity. This study evaluated the effects of perinatal follow-up on the management of CCHD. Methods: The study was conducted on term neonates diagnosed with CCHD, who were monitored in the neonatology and pediatric cardiac intensive care unit between 1 January 2023 and 1 January 2024. The cases were categorized into CCHD with prenatal follow-up (Group I), CCHD born without follow-up at our hospital (Group II), and CCHD accepted from external centers (Group III). Neonatal mortality and morbidity outcomes of these cases that underwent surgical or interventional procedures were statistically evaluated. Results: During the study period, there were 280 neonatal cases (50% male). Among these cases, 30% were in Group I (n = 84), 20% in Group II (n = 56), and 50% in Group III (n = 140). The cesarean section rate was higher in Group I compared to the other groups (80% vs. 52% vs. 45%), and the preoperative lactate levels were lower (0.9 vs. 1.7 vs. 2.1). The anatomical diagnoses, ventricular physiology, operation time, and interventional procedure time were similar. After interventional or surgical procedures, morbidity (22% vs. 25% vs. 36%) and mortality rates (6% vs. 9% vs. 18%) were lower in Group I and Group II compared to Group III. Conclusions: All infants diagnosed with CCHD before birth should be delivered in a tertiary heart center, which positively contributes to neonatal mortality and morbidity. More effort is needed to improve prenatal screening programs.

OBJECTIVE:This study aimed to evaluate the value of platelet activation markers in predicting preeclampsia and its severity. Preeclampsia is a serious pregnancy complication that affects 3-5% of pregnancies and can lead to significant morbidity and mortality for both the mother and the fetus.METHODS:The study included 99 patients diagnosed with preeclampsia and 60 healthy pregnant women as a control group. Platelet activation markers such as mean platelet volume (MPV), platelet distribution width (PDW), platelet count, and plateletcrit were evaluated along with other clinical parameters.RESULTS:The results of the study showed that platelet activation markers, particularly PDW and MPV, are valuable in the diagnosis and follow-up of preeclampsia. However, they are not sufficient to predict the severity of the disease.CONCLUSION:The study suggests that platelet activation markers could aid in predicting, diagnosing, and managing preeclampsia. However, further research is needed to determine the role of these markers in predicting the severity of the disease. The findings of this study could contribute to the development of more effective strategies for the prevention and management of preeclampsia, which could ultimately improve maternal and fetal outcomes.

Objective: Abnormal localization of the placenta with complete or partial closure of the cervix is called placenta previa. Placenta previa occurs in approximately 0.3-0.5% of pregnancies. In this study, we aimed to determine the risk factors and adverse fetal outcomes by comparing the neonatal outcomes of patients who underwent cesarean section for placenta previa with those of patients who underwent cesarean section for other indications. Method: Patients with singleton pregnancies diagnosed with placenta previa were retrospectively analyzed. Placenta previa, risk factors, and adverse neonatal outcomes were estimated using multivariate logistic regression models. Results: A total of 61,110 deliveries were analyzed, and 632 deliveries (288 patients, 344 controls) were included in the study. The prevalence of placenta previa was 0.47%. Advanced maternal age [odds ratio (OR)=3.03], multigravida (≥5) (OR=2.31), previous abortion (OR=1.58) and curettage (OR=2.32) were significant risk factors for placenta previa. However, these patients had an increased risk of 1st minute Apgar score <7 (OR=1.59) and neonatal intensive care unit (NICU) admission (OR=2.15). At the same time, the risk of Apgar score <7 at 1 min (OR=5.59) and 5 min (OR=3.94) and NICU admission (OR=28.47) increased in infants of patients with placenta previa <34 weeks. Newborns in the >37 weeks gestational age group with placenta previa were more likely to have a lower birth weight (OR=4.21) and an Apgar score <7 at 5 min (OR=1.89). Conclusion: Pregnancies with a diagnosis of placenta previa were associated with an increased risk of serious fetal outcomes compared with cesarean deliveries for all other indications, regardless of delivery timing.

OBJECTIVE:To compare salpingectomy and detorsion procedures and investigate the biochemical and histopathological changes in the fallopian tubes in the experimentally isolated fallopian tube torsion model in rats. DESIGN:Experimental study. SETTING:Experimental surgery laboratory in a training and research hospital. ANIMAL(S):Twenty-seven Sprague-Dawley rats in the reproductive period. INTERVENTION(S):Group 1, control group (n = 6); group 2, bilateral total salpingectomy group after 4 hours of tubal ischemia (n = 7); group 3: 4 hours of bilateral tubal ischemia plus 1 week of reperfusion (n = 7); and group 4, 4-hour period of bilateral tubal ischemia plus 30 days of reperfusion (n = 7). A 22-gauge catheter was administered before and after surgery using methylene blue through the uterine horn of the rat to evaluate tubal patency. MAIN OUTCOME MEASURE(S):Preoperative and postoperative serum antimüllerian hormone (AMH) levels, histopathological examination of the rat tuba uterine and histopathological damage scores, antioxidant compounds (superoxide dismutase [SOD], catalase, and glutathione peroxidase [GSH-Px]), and oxidative stress end product levels (malondialdehyde [MDA] and 8-hydroxy-2'-deoxyguanosine [8-OHdG]). RESULT(S):Although a significant difference was observed in the tissue SOD, GSH-Px, MDA, and 8-OHdG values, no significant difference was observed between the groups in serum samples. The tissue SOD and tissue GSH-Px levels in group 2 significantly decreased, and a significant increase was observed in the tissue MDA and 8-OHdG values in group 2. Among the histopathological parameters, epithelial changes, vascular congestion, and the total fallopian tube mean damage score of 4 showed a significant decrease in group 4. When the methylene blue transitions before and after ischemia-reperfusion injury were compared, the values of the methylene blue transition after ischemia-reperfusion injury in groups 2-4 significantly decreased. When the serum AMH levels were analyzed, the postoperative AMH value in group 2 significantly increased. CONCLUSION(S):This study reveals that biochemical and histopathological improvement is observed in the fallopian tube tissues gradually when the detorsion procedure is performed for the necrotized tubal tissue instead of salpingectomy. Although there is restoration of epithelial integrity after reperfusion, tubal passage remains absent. CLINICAL TRIAL REGISTRATION NUMBER:This study was approved by the Local Ethics Committee for Animal Experiments of the Health Sciences University, Istanbul Hamidiye Medicine Faculty (approval number 27.05.2022-9269). The study followed the ethics standards recommended by the Declaration of Helsinki.

Objetivo: El estudio tuvo como objetivo determinar el valor de los marcadores de activación plaquetaria en la predicción de la preeclampsia y su gravedad. Método: Se incluyeron 99 pacientes diagnosticadas con preeclampsia, incluyendo 36 casos graves, y un grupo control de 60 mujeres embarazadas sanas. Se evaluaron diversas variables, como el volumen plaquetario medio, el recuento de plaquetas, el hematocrito plaquetario y la amplitud de distribución plaquetaria. Resultados: Los resultados mostraron que el volumen plaquetario medio y la amplitud de distribución plaquetaria son parámetros valiosos en el diagnóstico y seguimiento de la preeclampsia, aunque no son suficientes para predecir su gravedad. El análisis estadístico reveló que la edad, el volumen plaquetario medio, la amplitud de distribución plaquetaria, la semana de gestación y los puntajes de Apgar al primer y quinto minuto fueron significativamente diferentes en el grupo de preeclampsia en comparación con el grupo control. Conclusiones: En conclusión, estos resultados sugieren que los marcadores de activación plaquetaria pueden ser útiles para el diagnóstico y seguimiento de la preeclampsia, y que el volumen plaquetario medio y la amplitud de distribución plaquetaria, por ser parámetros económicos y accesibles, podrían ayudar a predecir, diagnosticar y manejar esta complicación durante el embarazo.

Entrapped placenta following vaginal delivery is an uncommon complication. In resistant cases, it needs to be removed by laparotomy, although this is exceptionally rare. Here, we report a 28-year-old woman, 33 weeks pregnant through in vitro fertilization, who delivered a premature male baby weighing 2400 grams with an Apgar score of 7. After delivery, the placenta remained in the unicornuate uterus. Ultrasound ruled out placenta accreta spectrum, and manual removal attempts under anesthesia failed due to lower uterine segment contraction despite using nitroglycerine. Conservative management with misoprostol and broadspectrum antibiotics was initiated. However, increasing C-reactive protein levels and abdominal pain necessitated a computerized tomography scan, revealing the placenta trapped in the unicornuate uterus. Thirty-six hours after the delivery, the decision was made to remove the placenta laparoscopically instead of laparotomy. A unicornuate uterus containing a placenta on the right and the left rudimentary horn connected to the right uterus with bilateral adnexa, including theca cysts, were revealed during laparoscopic observation. No pelvic organ injury was noted. The placenta was removed via a fundal incision with a monopolar hook and using claw traumatic forceps. The uterus was closed with V-lock sutures; additional Zsutures were applied. A 270-gram entire placenta was extracted using an endo bag successfully. The patient was discharged several days after the procedure without any complications. Laparoscopic extraction of a third-trimester placenta can successfully be used in resistant cases while avoiding laparotomy, even in the early postpartum period.

OBJECTIVE:This study focuses on evaluating the effectiveness, safety and efficacy of 2 surgical tissue extraction methods for treating bowel endometriosis: natural orifice specimen extraction (NOSE) and minilaparotomy. DATA SOURCES:A systematic search was conducted in MedLine, Embase, and Cochrane Library databases in October 2023, without date restrictions. METHODS OF STUDY SELECTION:This study included studies that directly compared NOSE and minilaparotomy in colectomy patients due to endometriosis. Primary outcomes were defined as operation duration, length of hospital stay, intraoperative blood loss, and major postoperative complication rates. The Clavien-Dindo classification was used to categorize complications. Statistical analysis was performed using Review Manager Software by Cochrane, with a DerSimonian and Laird random-effects model to account for anticipated high heterogeneity. Subgroup analysis was conducted for patients undergoing full laparoscopic (L/S) resection. TABULATION, INTEGRATION AND RESULTS:Out of 1236 identified studies, 6 met the inclusion criteria, comprising 372 patients. One study was a randomized controlled trial, and 5 were observational. Operation duration did not significantly differ between NOSE and minilaparotomy (MD: -10.85 min; 95% CI: [-23.33, 1.63]; p = .09). NOSE was associated with a significantly reduced length of hospital stay (MD: -0.76 day; 95% CI: [-1.21, -0.31]; p = .008). The major postoperative complication rates were 3.77% for NOSE and 5.55% for minilaparotomy, with no significant difference (OR: 0.84; 95% CI: [0.27, 2.60]; p = .76). Subgroup analysis revealed that Full L/S had significantly shorter operation duration (MD: -26.06 min; 95% CI: [-45.85, -6.27]; p = .01), reduced length of stay (MD: -0.75 day; 95% CI: [-1.25, -0.25]; p = .003), and lower blood loss (MD: -15.01 mL; 95% CI: [-29.64, -0.37]; p = .04). CONCLUSION:NOSE emerged as a potentially safer alternative to minilaparotomy for tissue extraction in colectomy for bowel endometriosis. However, standardization of the procedure and additional randomized controlled trials are needed to validate these findings.

The aim of this study was to evaluate maternal serological status and fetal sonographic findings of Cytomegalovirus (CMV) infection. This is a retrospective study performed at Perinatology Department of Istanbul Başakşehir Çam and Sakura City Hospital. A computerized search was conducted to identify cases who underwent prenatal diagnosis of fetal CMV infection between September 2020 and December 2023. We identified nine cases with fetal CMV infection. The clinical data of the patients, gestational age at the time of diagnosis, serological, sonographic findings, and pregnancy outcomes were analyzed. A computer search of the database was made for the seroprevalance of CMV-IgM and CMV-IgG in our population. The CMV-IgM and IgG results of the 1235 patients who underwent CMV screening in the first trimester between September 2020 and December 2023 were evaluated. Fetal CMV infection was identified in nine patients. None of the 9 cases showed maternal CMV-IgM positivity. Seven of the 9 patients showed high IgG avidity index. Pregnant population had 98 % positivity for CMV-IgG. The evaluation of serologic tests for CMV is not straightforward in the second and third trimester. IgM and IgG avidity should be interpreted with caution in the second and third trimester. In the presence of ultrasound findings suggesting fetal CMV infection and CMV-IgG positivity, invasive diagnostic tests rather than serological test should be discussed with the patient, and non-primary infections should always be considered to minimize overlooked fetal cytomegalovirus infections and missed antiviral treatment opportunity.

Background: The perinatal and neonatal outcomes of Syrian refugees during the coronavirus disease 2019 (COVID-19) pandemic are unknown. Therefore, in this study, we aimed to evaluate these outcomes. Methods: Turkish (n = 303) and Syrian refugees (n = 303) who delivered in our hospital between June 1, 2020 and December 31, 2020 were included in the study. Demographic, perinatal, and neonatal data were obtained by retrospectively evaluating hospital records. Results: Adolescent pregnancy was more common in Syrian refugees (p < 0.001). The rates of antenatal visits, performed combined test, triple test, quadruple test, fetal anatomy ultrasound, and glucose tolerance test were lower in all refugees (p < 0.01). Furthermore, there was no difference in the mode of delivery, Hb after delivery, gestational age, birth weight, Apgar score, stillbirth, and fetal anomaly (p > 0.05 for all). Conclusion: Despite poorer antenatal care during the COVID-19 pandemic, Syrian refugee pregnant women had similar perinatal and neonatal outcomes compared with the Turkish pregnant population.

Objective: This study aims to assess Bisphenol-A levels in serum samples from preeclampsia patients and determine potential distinctions by comparing them against samples from healthy pregnant women Material-Methods: This single-center prospective case-control study aimed to investigate the potential differences in serum Bisphenol-A (BPA) levels between pregnant patients diagnosed with preeclampsia and healthy pregnant women. The study encompassed two distinct groups: the study group consisted of 30 pregnant patients diagnosed with preeclampsia, while the control group included 30 healthy pregnant women matched in terms of gestational weeks and demographic characteristics, maintaining a 1:1 ratio. Serum samples were subjected to analysis using a BPA ELISA kit Results: The study encompassed a total of 60 patients, who were categorized into two groups: preeclampsia (n=30) and control (n=30). Upon comparison of the BPA values between the two groups, no statistically significant difference was detected (p=0.579). Conclusion: Clear-cut scientific evidence establishing a conclusive causal link between BPA and preeclampsia is still lacking. Further research is needed in this area

Amaç: Bu çalışmada plasenta previa tanılı hastaların, operasyonlarından sonraki dönemde depresif belirti şiddetleri araştırıldı ve uterusu kaybetmenin sonucunda duygu durumlarındaki değişim incelendi. Gereçler ve Yöntem: Çalışmaya Mart 2012-Kasım 2014 tarihleri arasında plasenta previa nedeniyle sezaryen histerektomi yapılan toplam 59 hasta ile aynı tanı nedeniyle sezaryen olan ancak histerektomi yapılmayan toplam 60 hasta alındı. Hastalarda depresyon varlığı araştırıldı ve Beck Depresyon Ölçeği (BDÖ) ile depresif belirti şiddeti değerlendirildi. Bulgular: Peripartum histerektomi yapılan hasta grubunda ortalama BDÖ puanı 11±6, histerektomi yapılmayan grupta ise 4±2 bulundu. Histerektomi yapılan grupta ortalama BDÖ puanları istatistiksel olarak anlamlı bulundu (p