In classic scabies, mite burden is typically low, whereas crusted scabies exhibits massive infestation. During recent surges in presentations, we observed immunocompetent patients with non-crusted scabies referred for persistent or relapsing symptoms after standard topical therapy, who appeared to carry higher burdens. We aimed to estimate the frequency of a pragmatic high-load scabies phenotype among patients presenting with apparent topical treatment failure and to summarize its clinical features and outcomes. In a prospective, multicenter cohort across 10 dermatology centers in Türkiye, we enrolled patients with suspected scabies who had persistent or relapsing symptoms despite standard therapy and fulfilled a predefined high-load phenotype (≥ 50 mite-confirmed burrows on dermoscopy). The primary endpoint was Day-28 dermoscopic clearance, defined as no mites/ova and no new burrows at index sites. At baseline, all burrows were counted under a shared standard operating procedure (SOP). High-load scabies was defined a priori as ≥ 50 burrows. Of 3,316 patients screened, 76 (2.3

BACKGROUND:Demodex mites have been implicated in the pathogenesis of many dermatologic diseases, especially rosacea. Although many case reports have been published about the treatment of skin diseases caused by Demodex folliculorum mite, no relevant treatment algorithm has been developed so far. In this context, we investigated the lethal effects of different doses of benzyl benzoate on this mite. OBJECTIVE:To compare the lethal effects of 3 different doses of benzyl benzoate on Demodex folliculorum mites with those of a control group consisting of immersion oil. MATERIALS AND METHODS:Waste samples collected from rosacea patients were included in the study. Four different groups of 20 mites were formed. Each group was exposed to 5%, 10%, and 25% concentrations of benzyl benzoate, respectively. Immersion oil was used as a negative control group. The movements of the mites were monitored with a digital microscope. The time to death of the mites was recorded. RESULTS:The mean time to death of mites was 26 ± 2,9, 120 ± 7.6, and 168 ± 15 min after application of benzyl benzoate at concentrations of 25%, 10%, and 5%, respectively. The mean time to death of mites in immersion oil applied as a negative control group was 192 ± 6.4 min. Among the study groups, only the 25% benzyl benzoate group had a statistically significantly shorter mean time to death compared to the control group (p = 0.03). CONCLUSION:While low concentrations of benzyl benzoate were ineffective in the treatment of demodicosis, benzyl benzoate at high concentrations, e.g., 25%, was found to be effective in its treatment.

Aims: The aim of this study is to evaluate the prevalence of Demodex mites in the intranasal follicles of patients with allergic rhinitis and investigate their potential role in the etiology of allergic rhinitis. Methods: The study involved 50 patients diagnosed with allergic rhinitis and 50 healthy controls matched for age and gender. The severity of the disease was evaluated using the Score for Allergic Rhinitis and the Total Nasal Symptom Score (TNSS). To evaluate the presence of Demodex in nasal follicles, a total of 8 terminal follicles, 4 from each of the right and left nasal vestibules, were epilated using sterile forceps. The samples were examined under a light microscope at 10x, 40x, and 100x magnification by two dermatologists. Results: Demodex mites were found in the intranasal follicles of 3 (6%) individuals from the healthy control group. Intranasal Demodex mites were found in 3 (6%) patients with allergic rhinitis, showing no statistically significant difference between the two groups (p=1). The mean total nasal symptom score was 7.66±1.52 in the 3 allergic rhinitis patients with Demodex positivity, and 7.61±1.13 in the 47 patients without Demodex infestation, with no statistically significant difference between the two groups (p>0.05). No significant correlation was observed between Demodex positivity, disease severity, and TNSS in patients with allergic rhinitis (p>0.05). Conclusion: Based on our study results, we think that intranasal antiparasitic treatments may be unnecessary in patients with allergic rhinitis.

In this study, we have aimed to determine the in vitro and in silico effects of 23 frequently used dermatologic drugs on human carbonic anhydrase I (hCA I) and II (hCA II). The inhibitory effects of the drugs on hCA I and hCA II were determined by esterase methods. The most potent inhibitors were isotretinoin for hCA I (Ki= 5.75 µM) and valaciclovir for hCA II (Ki= 5.74 µM). Ketotifen (Ki= 6.98 µM), pantoprazole (Ki= 7.16 µM) and acyclovir (Ki= 7.31 µM) were also potent inhibitors for hCA I. Isotretinoin (Ki= 6.54 µM), brivudine (Ki= 7.44 µM) and fluconazole (Ki= 7.91 µM) were also potent inhibitors for hCA II. Terbinafine hydrochloride was a weak CA inhibitor for both of these isoenzymes (Ki= 20.58 µM for hCA I and 20.32 µM for hCA I). Therefore, the drug, having a weak CA inhibitory activity, may be preferred primarily in patients with a skin disease compared to the other drugs due to important physiological functions of CAs. Molecular docking studies have shown that acitretin and isotretinoin, in particular, will inhibit hCA I at lower concentrations and have higher docking scores. For hCA II, it was shown that Isotretinoin and Ketotifen would inhibit at lower concentrations and have higher placement scores.

Purpose: The aim of this study was to evaluate the in vitro scabicidal activity of vinegar at concentrations of 100%, 50%, and 25%, and to compare its efficacy with 5% permethrin to determine its potential as an alternative therapeutic option Materials and Methods: A total of 50 intact and motile Sarcoptes scabiei mites were included. The mites were extracted from patients' burrows under dermoscopic guidance using a 22G needle, and only intact, actively moving specimens were selected. Five groups were tested: Group I (100% vinegar), Group II (50% vinegar), Group III (25% vinegar), Group IV (5% permethrin; positive control), and Group V (oil immersion; negative control). Survival time was defined as the interval from exposure to the test solution until the complete cessation of mite movement, and this was monitored in real time using a digital microscope. Ten mites were evaluated in each group. Results: In Group I (100% vinegar; 0.6 +/- 0.1 min), Group II (50% vinegar; 11.8 +/- 1.4 min), and Group IV (5% permethrin; 336 +/- 37.2 min), complete mortality of Sarcoptes scabiei was achieved within the first eight hours of exposure. In contrast, mites in Group III (25% vinegar; 1782 +/- 87.9 min) and Group V (oil immersion; 1836 +/- 82.3 min) remained viable at the 8-hour evaluation. Both undiluted and 50% vinegar exhibited markedly greater scabicidal activity compared with the other groups. Conclusion: Although undiluted vinegar carries a risk of irritant contact dermatitis, 50% diluted grape vinegar retains substantial scabicidal efficacy. It exhibited a significantly greater killing effect compared with 5% permethrin while simultaneously reducing the risk of skin irritation, thereby representing a potentially safer alternative.

Aims: Scabies is a highly contagious ectoparasitic infestation commonly observed in childhood. Its diagnosis and treatment can be challenging due to atypical clinical presentations that overlap with other dermatological conditions. This study aims to evaluate the diagnostic and therapeutic approaches of pediatricians toward scabies and highlight the variabilities in their clinical practices. Methods: Online survey forms were distributed to pediatric specialists and residents practicing across Turkiye. The questionnaire included items on demographic characteristics, clinical approaches, treatment preferences, and management of close contacts. Results: A total of 459 pediatricians participated in the study. The most commonly preferred first-line treatment agent was permethrin lotion (60.3%), while the use of ivermectin was limited (1.3%). In addition, 64.5% of the participants reported prescribing magistral preparations in their daily practice, and 90% stated that they recommended treatment for family members. Clinical findings were most frequently used for diagnosis (96.5%), whereas laboratory confirmation was rarely requested. Approximately one-quarter of the participants believed that scabies could also be transmitted from animals. These results demonstrate considerable variability in knowledge and clinical practice. Conclusion: This study has revealed notable variabilities among pediatricians in the diagnostic and therapeutic approaches used to treat scabies. Practical challenges in the clinical setting underscore the need for improved integration of current guidelines and implementation of targeted educational programs.

Aim: This study aims to compare serum paraoxonase 1 (PON1) activity between patients diagnosed with acne vulgaris (AV) and a healthy control group, and to determine the PON1 phenotype. Materials and Methods: The study sample consists of 50 patients with moderate to severe AV who presented to the Clinic of Dermatology at Bal & imath;kesir University Faculty of Medicine. Additionally, healthy volunteers (n = 52) with similar age and gender characteristics to the patient group were included as the control group. The diagnosis of AV was made using the Global Acne Grading System. The serum PON1 activities in both AV patients and healthy volunteers were measured by spectrophotometric methods, and statistical comparisons were made among the groups. Furthermore, the PON1 phenotypic polymorphism was determined. Results: In our study, serum PON1 activity levels were found to be significantly lower in AV patients (36,149 +/- 14,536) compared to the control group (48,173 +/- 18,753) (P = 0.001). The distribution of PON1 phenotypes demonstrated a trimodal pattern. In the patient group, the QQ phenotype was observed in 48%, odds ratio in 24%, and risk ratio in 28%. In the control group, these rates were 5.8%, 44.2%, and 50%, respectively. Conclusion: The notably reduced activity of the antioxidant enzyme PON1 in patients with AV, as compared to the control group, indicates that oxidative stress could be a significant factor in its etiopathogenesis.

The working principle of a dark-field microscope is to block the central light from illuminating the preparation and to ensure that only oblique-oriented light reaches the specimen. Initially, the view appears dark, but when placing the appropriate specimen, the sample's particles change the direction of the oblique light toward the objective and ocular.1 Dark-field microscopy is useful for displaying Treponema pallidum spirochetes. However, dark-field microscopes are quite expensive compared to light microscopes and are not widely available among dermatology practices.

OBJECTIVE:Cutaneous larva migrans (CLM) is a parasitic disease seen in people in contact with soil in tropical countries. Almost all cases reported in regions without a tropical climate have a history of travel to a tropical region. AIM:In our study, we aimed to investigate the effect of climate change on CLM cases and the demographic characteristics of these cases. For this purpose, the climate information of the period in which we determined the case series and the characteristics of the patients were investigated. MATERIAL AND METHOD:The study was designed retrospectively. Patient files and pre- and post-treatment photographic archives were reviewed retrospectively. In addition, the region's weather history over the last 50 years was examined. RESULTS:The records of patients diagnosed with CLM in 2018 were reviewed retrospectively. In total, 22 cases were detected. The common feature of all cases was that they worked as tea pickers. After examining the weather conditions of the period when the cases were commonly reported, it was determined that there was a sharp temperature increase compared with previous years. CONCLUSION:Due to climate change, an increase in the number of CLM cases is observed in non-tropical regions. Since it is considered a disease-specific to tropical regions, the diagnosis may be overlooked in cases outside these regions. However, CLM should be kept in mind as a diagnostic possibility by clinicians practicing in non-tropical regions as well, especially when treating patients who work with soil, such as tea harvesters.

''Beyaz gömleğinle bir laboratuvardaİnsanlar için ölebileceksin,Hem de yüzünü bile görmediğin insanlar için,Hem de hiç kimse seni buna zorlamamışken,Hem de en güzel,En gerçek şeyin yasamak olduğunu bildiğin halde’’Nazım Hikmet COVID-19 pandemisinde aramızdan ayrılan tüm Azizsağlık şehitlerimize ithaf olunur

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Ozturk S, Can I. Perifolliculitis capitis abscedens et suffodiens accompanied by marginal keratitis. Archives of Medical Science - Aging. 2018;1(1):1-2. doi:10.5114/amsa.2018.73356. APA Ozturk, S., & Can, I. (2018). Perifolliculitis capitis abscedens et suffodiens accompanied by marginal keratitis. Archives of Medical Science - Aging, 1(1), 1-2. https://doi.org/10.5114/amsa.2018.73356 Chicago Ozturk, Savas, and Ilkay Can. 2018. "Perifolliculitis capitis abscedens et suffodiens accompanied by marginal keratitis". Archives of Medical Science - Aging 1 (1): 1-2. doi:10.5114/amsa.2018.73356. Harvard Ozturk, S., and Can, I. (2018). Perifolliculitis capitis abscedens et suffodiens accompanied by marginal keratitis. Archives of Medical Science - Aging, 1(1), pp.1-2. https://doi.org/10.5114/amsa.2018.73356 MLA Ozturk, Savas et al. "Perifolliculitis capitis abscedens et suffodiens accompanied by marginal keratitis." Archives of Medical Science - Aging, vol. 1, no. 1, 2018, pp. 1-2. doi:10.5114/amsa.2018.73356. Vancouver Ozturk S, Can I. Perifolliculitis capitis abscedens et suffodiens accompanied by marginal keratitis. Archives of Medical Science - Aging. 2018;1(1):1-2. doi:10.5114/amsa.2018.73356.

Dermatolojik muayenede ilk bakıda tüm vücutta yaygın ve dağınık yerleşimli, çeşitli boyutlarda eritemli skuamlı papüller ve plaklar dikkat çekiyordu (Resim 1). Lezyonların dikkatli incelemesinde bazı papüllerin oldukça keratotik olduğu (Resim 2), bazılarının ise daha yüzeyel olup etrafında bir bordür ve bu bordürün altında ip gibi uzanan ince bir oluk bulunduğu gözlendi (Resim 3). Hastanın ayrıca sırtında sağ skapula alt kısmında 0,5x1 cm Arzu Kılıç, Hande Akıncı*, Sevim Harman**, İlkay Can***, Ali Can Kazandı**** Bir Olgu, Dört Dermatoz: Psoriasis, Porokeratoz, Bazal Hücreli Karsinoma ve Verruka Vulgaris A Case, Four Diagnoses: Psoriasis, Porokeratosis, Basal Cell Carcinoma and Verruca Vulgaris

Introduction Renal involvement in leprosy has previously been described in the literature and can include amyloidosis, glomerulonephritis, nephrosclerosis, tubulointerstitial nephritis, and granulomas. Aim To evaluate renal involvement in Turkish patients with leprosy. Material and methods In total, 32 patients with lepromatous leprosy but without any co-morbidities and 35 healthy control subjects were evaluated for renal involvement at the Elazig Training and Research Hospital in Turkey. The laboratory tests and radiological results concerning renal function were taken from both the patients’ medical records and from current examinations. Results The levels of creatinine, urea, and leukocyturia in the lepromatous leprosy patients were significantly higher than in the controls (p < 0.001, p < 0.001; p = 0.001, p < 0.01; p = 0.036, p < 0.05, respectively). No significant differences in the proteinuria, hematuria, sodium, or potassium levels were found between the leprosy and control groups (p > 0.05). On ultrasonographic examination, the prevalence of renal cortical cysts and renal cortical echogenicity in the leprosy patients was significantly higher than in the controls (p = 0.020, p < 0.05, respectively). There were no significant differences in terms of nephrolithiasis, parapelvic cysts, or hydronephrosis between the leprosy and control groups (p > 0.05). Conclusions Evaluating the renal function in all leprosy patients is important to detect abnormalities and to prevent renal failure, which remains a potential cause of death in this disease.

Indian Journal of Dermatology, Venereology, and Leprology | March-April 2017 | Vol 83 | Issue 2 218 necrosis in the biopsy specimen. The Mantoux test is positive in most cases, as in our case. The absolute criteria for the diagnosis of cutaneous tuberculosis include a positive culture of M. tuberculosis from the lesion or deoxyribonucleic acid amplification by polymerase chain reaction. However, the culture was negative and polymerase chain reaction could not be performed in our case. A therapeutic trial with antitubercular therapy is justified, if clinical suspicion is strong and the diagnosis can be made based on the therapeutic response.