WES analysis for all mouse SCCs and UVB-treated samples.

Opal and CODEX multiplexed tissue imaging data shows infiltration of proliferative CD8+ T-cells to the rejected SCCs.

Differentially expressed genes in tumor compartment at days 0, 6, 10, and 16 post-inoculation.

Differential expression analysis of rejected vs. non-rejected tumor cells.

Transcriptional changes in the Mif KO compared to Mif WT tumors.

List of antibodies used for IHC staining of human samples.

Supplementary data linked to the in vivo CRISPR screen.

Clinical data and characterization of the single-cell clones.

CellChat and CellPhoneDB analyses reveal increased MIF signaling from tumor cells to macrophages in non-rejected clones.

Immunopeptidomics and TCR sequencing analyses showed similar results for the rejected and non-rejected SCCs.

Cell types from scRNA-seq of tumors from mice inoculated with rejected or non-rejected SCCs.

Evaluation of Mif expression in stromal cells, and its effect on patient survival.

scRNA-seq characterization of Mif KO tumor clones.

List of antibodies used for CODEX multiplexed tissue imaging

List of primers used for sgRNA library generation

CyTOF analysis comparing tumors derived from Mif WT and Mif KO validating the scRNAseq findings.

CD8+ T cell depletion data. Supplemental figure to Figure 6F.

Analysis of tissue microarray of biopsies from cancer patients.

Pathway enrichment in samples at days 6, 10, 16, and 20 post-inoculation.

Rejection and non-rejection gene sets identified in the scRNA sequencing analysis can stratify patients with high/low ITH and hot/cold tumor annotations.