We aimed to investigate the association of emerging infectious disorders with Guillain-Barré syndrome (GBS) in Colombia following the 2015–2016 Zika outbreak.

To characterize the epidemiological, clinical, and laboratory features of cases of encephalitis of unknown etiology included in the NEAS cohort.

To evaluate clinical, laboratory, and epidemiological features of acute neuroinflammatory disorders (ANIDs) that followed the 2016 Zika epidemic in Colombia.

Objective: NA Background: Outbreaks of Chikungunya and Zika virus infection emerged in the Americas in 2014 and 2015. Along with such outbreaks, an increase in the incidence of disorders such as Guillain-Barre syndrome (GBS), encephalitis and other acute neuroinflammatory disorders was observed. The Neuroviruses Emerging in the Americas Study (NEAS) was established in Colombia as a multicenter-based observatory of acute neuroinflammatory disorders (ANIDs) to investigate the role of viral infections as etiological factors in neuroinflammatory disease. Design/Methods: NEAS network comprises clinical centers localized in 7 cities in Colombia. Patients with ANIDs fitting the criteria for GBS, encephalitis, myelitis, meningoencephalitis and cranial nerve disorders were evaluated clinically and with molecular and/or immunological diagnostic methods to investigate the role of viral infections as etiological factors. Results: Between 2016 and August 2019, 523 patients with ANIDs were studied. Of this group, 149 were recruited prospectively along with 97 controls for studying clinical and biological biomarkers of exposure to infection. GBS cases (249, 47.6%) and facial paralysis (169, 32.3%) were the most frequent ANIDs while encephalitis (29, 5.4%), optic neuritis (18, 3.4%) and myelitis (19, 3.4%) were less frequent. Almost 60% of GBS cases had a demyelinating type as compared with 21% with axonal forms. While Zika-related GBS was frequent (36%) among GBS cases, mostly during the 2016 Zika epidemic, 22% of the GBS appeared to be associated with Campylobacter jejuni exposure, most of them during the post-Zika epidemic. Conclusions: An increased number of ANIDs was observed in Colombia after the 2016 Zika outbreak. More than half of the cases of ANIDs were related with GBS and cranial nerve involvement. Although Zika infection played an important role in the increase of GBS cases in 2016, current evidence indicates that C. jejuni is an important driver of pathogenesis of GBS during the post-Zika period in Colombia. Disclosure: Dr. Osorio has nothing to disclose. Dr. Vargas has nothing to disclose. Dr. Dominguez has nothing to disclose. Dr. Jimenez-Arango has nothing to disclose. Dr. Lizarazo has nothing to disclose. Dr. Lopez has nothing to disclose. Dr. Gonzalez-Manrique has nothing to disclose. Dr. Ramos has nothing to disclose. Dr. Zea-Vera has nothing to disclose. Dr. Angarita Diaz has nothing to disclose. Dr. Benavides has nothing to disclose. Dr. Martinez has nothing to disclose. Dr. Barreras has nothing to disclose. Dr. Garcia-Dominguez has received research support from Bart McLean Fund for Neuroimmunology Research. Dr. Quintero has nothing to disclose. Dr. Claros has nothing to disclose. Dr. Luque has nothing to disclose. Dr. Jaramillo Rojas has nothing to disclose. Dr. Rosso has nothing to disclose. Dr. Rojas has nothing to disclose. Dr. Urrego has nothing to disclose. Dr. Zuluaga has nothing to disclose. Dr. Ocampo has nothing to disclose. Dr. Morales has nothing to disclose. Dr. Rojas has nothing to disclose. Dr. Zuniga has nothing to disclose. Dr. Llanos has nothing to disclose. Dr. Moyano has nothing to disclose. Dr. Munoz-Arcos has nothing to disclose. Dr. Parra has nothing to disclose. Dr. Pardo-Villamizar has received research support from McLean’s foundation.

May 6, 2019April 9, 2019Free AccessGBS after the Zika-outbreak in Colombia: The newcomer is gone but the problem continues! (P2.6-039)Carlos Pardo-Villamizar, Guillermo Gonzalez-Manrique, Jorge Andres Jimenez-Arango, Jairo Lizarazo, Jose Vargas, Reydmar Lopez, Andres F. Zea, … Show All … , Jorge Angarita, Martha Moyano, Paula Barreras, Laura Munoz-Arcos, Jaime A. Quintero, Susana Dominguez, Gustavo Ramos, Cindy L. Beltran, Maria A. Garcia-Dominguez, Julie Benavides, David Cornblath, Beatriz Parra, and Lyda Osorio Show FewerAuthors Info & AffiliationsApril 9, 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P2.6-039 Letters to the Editor

Objetivo. Determinar el estado de salud oral de pacientes adultos atendidos en la Clínica Odontológica de la Universidad Cooperativa de Colombia sede Pasto en relación con su nivel de depresión. Métodos. Se incluyeron 88 pacientes adultos atendidos durante el año 2014, a quienes se les aplicó voluntariamente una encuesta sobre aspectos sociodemográficos, higiene oral y el test de Beck. Se hizo un análisis univariado y bivariado, con cálculo del OR y un IC95% para determinar la prevalencia de la depresión en la población y su relación con las alteraciones orales. Resultados. El 17% de los pacientes presentó depresión (leve a extrema), todos con deficiente higiene oral, aunque sin relación estadísticamente significativa entre éstas variables (OR=0,26 IC95%[0,009-7,3]). Los pacientes con depresión presentaron una alta prevalencia de caries secundaria no cavitacional. Las mujeres fueron las más afectadas. Conclusiones. Se evidencia que prevalece la mala higiene oral en todos los niveles de la escala de salud mental de los pacientes atendidos en la Clínica Odontológica de la Universidad Cooperativa de Colombia sede Pasto. La interconsulta con profesionales de la psicología es un aspecto a considerar en la prestación integral de servicios de salud oral para mejorar su salud oral y calidad de vida

ABSTRACT The therapeutic efficacy of sulfadoxine-pyrimethamine (SP) in treating uncomplicated Plasmodium falciparum malaria is unevenly distributed in Colombia. The Andes mountain range separates regions in the west where malaria is endemic from those in the east and constitutes a barrier against gene flow and the dispersal of parasite populations. The distribution of dhfr and dhps genotypes of 146 P. falciparum samples from the eastern Amazon and Orinoco basins and Northwest and Southwest Pacific regions of Colombia was consistent with the documented levels of therapeutic efficacy of SP. The diversity of four dhfr- and dhps-linked microsatellites indicated that double- and triple-mutant alleles for both resistance loci have a single origin. Likewise, multilocus association genotypes, including two unlinked microsatellite loci, suggested that genetic exchanges between the eastern Orinoco and Northwest Pacific populations has taken place across the Andes, most probably via migration of infected people.