A specific method for the quantitation of digoxin in serum has been developed and applied to determination of drug concentrations in serum from digitalized patients. One ml of the supernatant from acetonitrile denatured serum, subsequently diluted with water, was chromatographed on a reversed phase HPLC column. The eluent corresponding to the retention time of digoxin was collected and analysed using a commercial radioimmunoassay kit. The recovery at 3ng/ml was 96.1 ± 3.0%. Endogenous substances, drugs and metabolites of digoxin do not interfere with the method. The mean value of the samples estimated by the present method was 84% of those determined by direct R.I.A.

The application of greenhouse vegetable cultivation has dramatically expanded worldwide during the last several decades. However, little information is available on the distribution and uptake of pesticides in greenhouse vegetables. To bridge this knowledge gap, the present study was initiated to investigate the distribution and uptake of organochlorine pesticides (OCPs) in vegetables from plastic greenhouse and conventional cultivation methods. The uptake pathways of OCPs were not significantly different between these two cultivation methods. The arithmetic means of OCP concentrations in greenhouse vegetables were higher than those in conventional vegetables, although there was no significant difference. This small difference raised the concern of whether the tiny difference could be magnified to a significant difference by bioaccumulation in the food chain. The issue should be addressed by a well-designed scheme in future studies.

Biopharmaceutics & Drug DispositionVolume 5, Issue 1 p. 97-100 Research Paper Pharmacokinetic evaluation of a conventional and controlled release product of betamethasone J. C. K. Loo, J. C. K. Loo Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorN. Jordan, N. Jordan Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorC. Charette, C. Charette Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorR. Brien, R. Brien Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorI. J. McGilveray, I. J. McGilveray Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this author J. C. K. Loo, J. C. K. Loo Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorN. Jordan, N. Jordan Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorC. Charette, C. Charette Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorR. Brien, R. Brien Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this authorI. J. McGilveray, I. J. McGilveray Bureau of Drug Research, Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario, Canada K1A 0L2Search for more papers by this author First published: January/March 1984 https://doi.org/10.1002/bdd.2510050113Citations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 J. C. K. Loo, I. J. McGilveray, N. Jordan and R. Brien, Biopharm. Drug Dispos., 2, 265 (1981). 2 K. Yamaoka, T. Nakagawa and T. Uno, J. Pharmacokinet. Biopharm., 6, 547 (1978). 3 S. Riegelman and P. Collier, J. Pharmacokinet. Biopharm., 8, 509 (1980). 4 J. C. K. Loo, C. Charette, N. Jordan and I. J. McGilveray, in Pharmacokinetics: A Modern View, L. Z. Benet and G. Levy (Eds), Plenum, New York (in press). Citing Literature Volume5, Issue1January/March 1984Pages 97-100 ReferencesRelatedInformation