A rapidly growing tumor in the temporal area extended into the infratemporal fossa. Imaging findings favored a hypervascularized meningo-sarcoma type extracranial tumor, but the pathology report on the surgical specimen confirmed the diagnosis of capillaro-venous angioma. The therapeutic approach was preoperative hyperselective embolization then access via the temporal and infra-temporal fossa for simple tumor exeresis. Mature angiomas and access via the infra-temporal fossa are reviewed.

Accumulation of p53 protein has been considered an intermediate biomarker in multistage oesophageal carcinogenesis. The aim of the present study was to investigate p53 expression by immunohistochemistry in 13 thoroughly sampled oesophagectomy specimens from a geographical area with a high oesophageal cancer incidence (Basse Normandie, France). Expression of p53 was looked for in tissue samples of cancer, intraepithelial neoplasia, and uninvolved mucosa. The streptavidin biotin peroxidase complex method was used for p53 immunostaining. p53 expression was found in invasive squamous cell carcinoma in 8 out of 11 cases and in intraepithelial neoplasia in 10 out of 11 cases. In all 13 cases, in uninvolved oesophageal mucosa, expression of p53 was focally present in areas of chronic oesophagitis. Chronic oesophagitis has been regarded by epidemiologists as a precursor lesion for squamous cell carcinoma of the oesophagus. Since oesophageal carcinogenesis is a multistage process, the study of precursor lesions could provide information on the timing of p53 gene abnormalities during oesophageal carcinogenesis. These preliminary data require to be confirmed by molecular analysis of the p53 gene.

DNA ploidy abnormalities of 21 archival human esophageal intraepithelial neoplasia samples were assessed, using image cytometry of deparaffinized samples, with reference to invasive squamous cell carcinoma and corresponding uninvolved squamous epithelium. Cytometric parameters investigated were proportion of G0G1 aneuploid cell population, histogram typing, proportion of G0G1 diploid nuclei, coefficient of variation, mean DNA content, crude 5c exceeding proportion, 2c deviation index, malignancy index and grade, and entropy. The distributions of the above parameters were compared using the paired t test and Fisher's exact test. Among 10 parameters used, Auer typing of DNA histograms, crude 5c exceeding rate, 2c deviation index and malignancy grade according to Böcking allowed discrimination between uninvolved epithelium and invasive squamous cell carcinoma as well as intraepithelial neoplasia. In particular, the distribution of 2c deviation index in the uninvolved epithelium did not overlap that of intraepithelial and invasive carcinomas. The above four parameters, however, were unable to discriminate intraepithelial neoplasia from invasive carcinoma.

Introduction. T cell prolymphocytic leukemia (T PLL) is a rare variant of mature lympho-proliferative disorder. The main physical sign is a gross splenic enlargment contrasting with no enlargment of lymph nodes. Skin involvement is found in 30 p. 100 cases. Twenty-one cases of cutaneous lesions of PLL have been reported, mainly with T PLL, only 2 cases of B PLL. Clinical lesions are polymorphous; histology shows a dermal prolymphocytic infiltrate. The main cytogenetic abnormalities are: translocation (14; 14) (q11; q32), inversion of chromosome 14 (q11; q32), isochromosome 8q. Case report. We report a case of an 87-year-old patient presenting a T cell prolymphocytic leukemia CD4+ with specific papular lesions of the back. Electron microscopy showed typical prolymphocytes and cytogenetic studies showed a tendency to polyploidy, with the lost of chromosome 14, translocation 8-22 and inversion of chromosome 13. After 12 months of treatment with a combination of chloraminophen and prednisone the patient was in partial remission and the cutaneous lesions disappeared. Discussion. This case is rare and the patient has an unusual long survival (mean survival is 7 months). Contrary to the other hematologic disorders, cutaneous involvement does nor change the prognosis of T PLL.

The authors describe the anatomopathological, clinical and evolutive characteristics of the metatypical carcinoma, based on four cases and on the existing literature. Evolution of these tumors, with a maxillo-facial preferential location, is usually longer than for other cutaneous carcinomas. Cases presented in this article illustrate the severity of such lesions, whose treatment requires extensive amputations and rather unusual reconstruction procedures.

International Journal of DermatologyVolume 33, Issue 8 p. 538-542 CUTANEOUS MALACOPLAKIA BRIGITTE RÉMOND M.D., Corresponding Author BRIGITTE RÉMOND M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Address for correspondence: Brigitte Remond, M.D., Service de Dermatologie, CHU Avenue Georges Clemenceau, 14033 Caen Cedex, France.Search for more papers by this authorANNE DOMPMARTIN M.D., ANNE DOMPMARTIN M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorANNE MOREAU M.D., ANNE MOREAU M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorPASCALE ESNAULT M.D., PASCALE ESNAULT M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorANNE THOMAS M.D., ANNE THOMAS M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorJEAN-CLAUDE MANDARD M.D., JEAN-CLAUDE MANDARD M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorDOMINIQUE LEROY M.D., DOMINIQUE LEROY M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this author BRIGITTE RÉMOND M.D., Corresponding Author BRIGITTE RÉMOND M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Address for correspondence: Brigitte Remond, M.D., Service de Dermatologie, CHU Avenue Georges Clemenceau, 14033 Caen Cedex, France.Search for more papers by this authorANNE DOMPMARTIN M.D., ANNE DOMPMARTIN M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorANNE MOREAU M.D., ANNE MOREAU M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorPASCALE ESNAULT M.D., PASCALE ESNAULT M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorANNE THOMAS M.D., ANNE THOMAS M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorJEAN-CLAUDE MANDARD M.D., JEAN-CLAUDE MANDARD M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this authorDOMINIQUE LEROY M.D., DOMINIQUE LEROY M.D. From the Service de Dermatologie, Centre Hospitalier Universitaire de Caen, France, and the Laboratoire d'Anatomo-pathologie, Caen, France.Search for more papers by this author First published: August 1994 https://doi.org/10.1111/j.1365-4362.1994.tb02888.xCitations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume33, Issue8August 1994Pages 538-542 RelatedInformation

BACKGROUND:The benefits of preoperative chemotherapy and radiation for esophageal carcinoma are under investigation. A pilot study was undertaken to determine if pathologic assessment of tumor regression correlated with disease free survival.METHODS:Ninety-three resected specimens from patients treated with cis-dichloro-diamino cisplatin and irradiation before surgery were examined on semiserial sections. Patients selected for surgery were all Status 1 according to the World Health Organization (WHO) classification. Histologic typing was based on the WHO classification. Tumor regression grade (TRG) was quantitated in five grades: TRG 1 (complete regression) showed absence of residual cancer and fibrosis extending through the different layers of the esophageal wall; TRG 2 was characterized by the presence of rare residual cancer cells scattered through the fibrosis; TRG 3 was characterized by an increase in the number of residual cancer cells, but fibrosis still predominated; TRG 4 showed residual cancer outgrowing fibrosis; and TRG 5 was characterized by absence of regressive changes. Survival curves were estimated according to the Kaplan-Meier method. A quantification of the relationship between treatment failure and confounding variables (age, tumor location, tumor size, esophageal wall involvement by residual cancer and/or regressive changes, histology, treatment, adequacy of surgery, pathologic lymph node status, and tumor regression grade) was done using Cox's proportional hazards model.RESULTS:Forty-two percent of specimens were TGR 1-2; 20%, TGR 3; and 33%, TGR 4-5. Univariate analysis found that tumor size, pathologic lymph node status, tumor regression grade, and esophageal wall involvement were highly correlated with disease free survival (P < 0.05). After multivariate analysis, only tumor regression (i.e., TRG 1-3 versus TRG 4-5) remained a significant (P < 0.001) predictor of disease free survival.CONCLUSIONS:This study highlights the importance of tumor regression in the survival of patients with esophageal carcinoma treated with preoperative chemoradiotherapy. These findings suggest that tumor regression grade should be considered when evaluating therapeutic results.

La malakoplakie est une maladie inflammatoire granulomateuse rare. Individualisee en 1902 par Michaelis et Gutmann, son nom revient a Von Hansemann qui la decrivit sous forme de plaques molles au niveau de la vessie. Environ 300 cas sont colliges dans la litterature, touchant surtout l'appareil urinaire (60 p. 100), digestif (20 p. 100) et retroperitoneal (15 p. 100) (1, 2). Plus recemment, ont ete decrites des atteintes ganglionnaires, de l'appareil genital, des poumons, des os, du cerveau et exceptionnellement de la peau (3, 4). D'etiopathogenie mal definie, la maladie est particulierement frequente chez l'immunodeprime. Nous rapportons ici un cas de malakoplakie cutanee chez un transplante cardiaque

Hyperplasia of Brunner's glands is a dysembryoplasic or hyperplasic lesion with an elective location of the proximal duodenum. Symptoms are often non-specific but severe manifestations can occur (haemorrhage, duodenal obstruction). Two cases of hyperplasia of Brunner's glands were reported due to their particularly large size and a misguiding clinical appearance. Difficulties in diagnosis due to this rare benign entity were discussed.

La malakoplakie est une maladie inflammatoire granulomateuse rare. Individualisee en 1902 par Michaelis et Gutmann, son nom revient a Von Hansemann qui la decrivit sous forme de plaques molles au niveau de la vessie. Environ 300 cas sont colliges dans la litterature, touchant surtout l'appareil urinaire (60 p. 100), digestif (20 p. 100) et retroperitoneal (15 p. 100) (1, 2). Plus recemment, ont ete decrites des atteintes ganglionnaires, de l'appareil genital, des poumons, des os, du cerveau et exceptionnellement de la peau (3, 4). D'etiopathogenie mal definie, la maladie est particulierement frequente chez l'immunodeprime. Nous rapportons ici un cas de malakoplakie cutanee chez un transplante cardiaque

Hyperplasia of Brünner's glands is a dysembryoplastic or hyperplasic lesion with an elective location of the proximal duodenum. Symptoms are often non-specific but severe manifestations can occur (haemorrhage, duodenal obstruction). Two cases of hyperplasia of Brünner's glands were reported due to their particularly large size and a misguiding clinical appearance. Difficulties in diagnosis due to this rare benign entity were discussed.

Cystic chondromalacia is a clinical and histopathological entity which can be clearly distinguish from all other cystic lesions of the auricle. We report a case which was clinically asymptomatic and involved the scaphoid fossa of the anterior surface of the pinna. The pathological process consisted of degenerative changes of the auricular cartilage which produced a cavity containing a serous fluid. No etiologic factor was found, in particular no trauma. The posterior wall of the cyst was excised under local anesthesia. This case allowed us to review the clinical, histopathological features and surgical difficulties of this rare lesion.

Two cases of acute megakaryoblastic leukemia in a 4 month-old and a 13 year-old girl are described. In the first case who presented with a large hepatomegaly and portal fibrosis, the diagnosis was made from the surface phenotyping of megakaryoblasts; a trisomy 13, 14 and 19 and an extra chromosome X were present in the bone marrow. An electron microscopy study of megakaryoblasts was necessary to identify the second case. Both children died shortly after treatment (cytosine-arabinoside at low dosage in the first case and polychemotherapy in the second). The 51 other cases reported in the literature are reviewed.

A 6 year - old boy with urinary incontinence, sensory loss and spastic weakness in lower limbs underwent surgical repair for low - lying spinal cord ending in an intradural lipoma. Within the lipoma, bundles and fascicles of striated muscles fibers were intimately associated with nerve fibers. This extremely rare histological appearance has been reported as benign << triton tumor >>. Our case allows a discussion of its histogenesis.