The aim of this study was to evaluate the type and incidence of untoward clinical events associated with the stimulation of ovulation for in vitro fertilization (IVF). Ovarian stimulation in 156 patients was based upon the combination of agonist of GnRH and hMG in a long protocol). Mean weight gain was 0,62 kg (range : 0-4 kg). It occurred in 65% of cases. Tiredness was noted during 40,3% of cycles, above all during the period of administration of hMG. The influence of the agonist was predominant in terms of headache (24,3%) and menorrhagia (16%). Abdominal distension (25,3%), breast discomfort (10BX), mucus (8,8 X) and leucorrhea (7,5%) were accentuated after the administration of hMG. Pelvic pain often occurred following injections of hCG. There was no difference between the various treatment periods concerning hot flushes (18,9%) and nausea (11%). Other side-effects (constipation, diarrhea, articaria, memory lose, visual disturbances, changes in libido) were found to a lesser extent.

81 patients who had consulted for infertility, of whom 26 had recurrent spontaneous abortions (RSA), 28 unexplained infertility (UI), and 27 with difficulties for implantation following in vitro fertilization (IVF) were tested by a cross-match for the presence of the partner's lymphocyte antibodies. When the result was negative, leucocyte transfusions were carried out (200 million of the partner's lymphocytes in 3 successive injections at intervals of one month). Positive antipaternal cytotoxic antibodies were found in 81% of cases. There was, however, no benefit in groups of unexplained infertility or implantation difficulties. In the RSA group there was a 50% recurrence of spontaneous abortions.