Jeffrey Eummer | AMiner学者主页

1Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.(vol 47, pg 1609, 2004)

BN Balasubramanian, DRS Laurent,MG Saulnier,BH Long,C Bachand,F Beaulieu,W Clarke,M Deshpande,J Eummer,CR Fairchild,DB Frennesson,R Kramer,

2005JOURNAL OF MEDICINAL CHEMISTRY（2005）

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2Discovery of a 1H-Benzoimidazol-2-yl)-1h-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

M Wittman,J Carboni,R Attar,B Balasubramanian, P Balimane,P Brassil,F Beaulieu, CY Chang,W Clarke,J Dell,J Eummer,D Frennesson,

Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is described. The in vitro and in vivo biological activity of this interesting compound is also reported.

2005JOURNAL OF MEDICINAL CHEMISTRY（2005）引用：129

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3Design and Synthesis of a Fluoroindolocarbazole Series As Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β-d-glucopyranosyl]-5h,13h-benzo[b]thienyl[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione (BMS-251873) with Curative Antitumor Activity Against Prostate Carcinoma Xenograft Tumor Model.

Bn Balasubramanian, Drs Laurent,Mg Saulnier,Bh Long,C Bachand,F Beaulieu,W Clarke,M Deshpande,J Eummer,Cr Fairchild,Db Frennesson,R Kramer,

A series of fluoroindolocarbazoles were studied with respect to their topoisomerase I activity, cytotoxicity, selectivity, and in vivo antitumor activity. Emerging from this series was BMS-251873, a potential clinical candidate possessing a robust pharmacological profile including curative antitumor activity against prostate carcinoma.

2004Journal of Medicinal Chemistry（2004）引用：35

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4The Synthesis of Structurally Novel Bridged Glycosidic Fluoroindolocarbazoles as Topoisomerase I Inhibitors

Edward Ruediger,Byron Long,Carol Bachand,Francis Beaulieu, Karen Bedingfield,Jeffrey Eummer,Craig Fairchild,David Frennesson,Mikael Mahler,Alain Martel,Mark Saulnier, Denis Laurent,

200319th International Congress on Heterocyclic Chemistry

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