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1Stimulation of Acetyl Coa Carboxylase by (-)-Hydroxycitrate

J HACKENSCHMIDT,C BARTH,K DECKER

FEBS LettersVolume 27, Issue 1 p. 131-133 Full-length articleFree Access Stimulation of acetyl-CoA carboxylase by (−)-Hydroxycitrate J. Hackenschmidt, J. Hackenschmidt Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, W. GermanySearch for more papers by this authorC. Barth, C. Barth Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, W. GermanySearch for more papers by this authorK. Decker, K. Decker Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, W. GermanySearch for more papers by this author J. Hackenschmidt, J. Hackenschmidt Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, W. GermanySearch for more papers by this authorC. Barth, C. Barth Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, W. GermanySearch for more papers by this authorK. Decker, K. Decker Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, W. GermanySearch for more papers by this author First published: October 15, 1972 https://doi.org/10.1016/0014-5793(72)80425-3Citations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume27, Issue1October 15, 1972Pages 131-133 ReferencesRelatedInformation

1972PubMed引用：26

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2Influence of Kynurenate on Cholesterol and Fatty-Acid Synthesis in Isolated Perfused Rat-Liver

C BARTH,J HACKENSCHMIDT,E WEIS,K DECKER

Cholesterol and fatty acid synthesis of the isolated perfused rat liver were measured by the 3H2O method. Kynurenate (10 to 40 mm) inhibited the rate of fatty acid synthesis by 60 to 88%. The rate of cholesterol synthesis, on the contrary, was not reduced at all by this inhibitor. These findings show that malonyl coenzyme A is not an intermediate in β-hydroxy-β-methylglutaryl-CoA formation in the intact organ and exclude the existence of a malonyl-CoA pathway of cholesterol synthesis in rat liver.

1972HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE（1972）引用：24

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3Die Wirkung von Gallensäuren auf die Cholesterinsynthese in der perfundierten Rattenleber

Ch. Barth,M. Liersch,J. Hackenschmidt, J. Ullmann,K. Decker

In der Rattenleber sind die Geschwindigkeit der Cholesterinsynthese und die Aktivität der HMG-CoA-Reduktase (E.C. 1.1.1.34) nach einer Diät mit hohem Cholsäuregehalt vermindert [1, 2]. Dieser Effekt tritt nach 4 bis 8 Std ein [3, 2]. Er wurde einerseits als direkter regulatorischer Angriff der Cholsäure am Schrittmacherenzym der Cholesterinsynthese („Gallensäure-Cholesterin-feedback“) [4] andererseits als sekundäre Folge der gesteigerten Resorption von Nahrungscholesterin durch die Darmmucosa („Cholesterin-Cholesterin-feedback”) [5] gedeutet. Versuche mit zellfreien Systemen ergaben ebenfalls widersprüchliche Ergebnisse [6, 2]; deren Relevanz wird generell dadurch gemindert, daß die in vivo in der Umgebung der HMG-CoA-Reduktase vorhandenen Gallensäurenkonzentrationen unbekannt sind.

1972Verhandlungen der Deutschen Gesellschaft für Innere MedizinAchtundsiebzigster Kongress（1972）

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4Influence of Bile Salts on Cholesterol Synthesis in the Isolated Perfused Rat Liver.

C BARTH,H ULLMANN,M LIERSCH,K DECKER,J HACKENSCHMIDT

The effect of taurocholate and cholate on hepatic cholesterol synthesis has been studied with the isolated perfused rat liver. By the infusion of bile salts at a constant rate to the portal vein, conditions in the enterohepatic circulation of taurocholate and cholate in vivo were simulated. A 1‐h infusion of sodium taurocholate, at a rate of 10mg × (100g body wt) −1 × h −1 , did not inhibit cholesterol synthesis, as measured by 3 H 2 O incorporation. The same results were obtained, when livers with enhanced cholesterol synthesis were studied or when bile salt infusions were extended to 2 h before starting incorporation measurements. Stimulation was achieved by feeding a 2% cholestyramine diet during 7 days to the donor animals. A 3‐h infusion of taurocholate, at the above rate, exerted no toxic effect on liver metabolism, as judged from hepatic enzyme leakage to the perfusion medium, from the rate of ketone body production and the 3‐hydroxybutyrate/acetoacetate ratio. Cholic acid in amounts equivalent to those of taurocholate did not influence cholesterol synthesis under these conditions. It is concluded, that inhibition of cholesterol synthesis by bile salts in vivo is not mediated by a short‐acting ( e.g. allosteric) mechanism at the enzymatic level, but rather by a change of enzyme content.

1972HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE（1972）引用：62

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5[Effect of Bile Acids on Cholesterol Synthesis in the Perfused Rat Liver].

C Barth,M Liersch,J Hackenschmidt, J Ullmann,K Decker

1972Verhandlungen der Deutschen Gesellschaft fur Innere Medizin（1972）引用：23

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6Inhibition of Cholesterol Synthesis by (−)‐hydroxycitrate in Perfused Rat Liver. Evidence for an Extramitochondrial Mevalonate Synthesis from Acetyl Coenzyme A

C BARTH,H ULLMANN,J HACKENSCHMIDT,K DECKER

FEBS LettersVolume 22, Issue 3 p. 343-346 Full-length articleFree Access Inhibition of cholesterol synthesis by (−)-hydroxycitrate in perfused rat liver. Evidence for an extramitochondrial mevalonate synthesis from acetyl coenzyme A C. Barth, C. Barth Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this authorJ. Hackenschmidt, J. Hackenschmidt Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this authorH. Ullmann, H. Ullmann Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this authorK. Decker, K. Decker Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this author C. Barth, C. Barth Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this authorJ. Hackenschmidt, J. Hackenschmidt Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this authorH. Ullmann, H. Ullmann Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this authorK. Decker, K. Decker Biochemisches Institut an der Medizinischen Fakultät I, Universität Freiburg im Breisgau, West GermanySearch for more papers by this author First published: May 15, 1972 https://doi.org/10.1016/0014-5793(72)80266-7Citations: 26AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume22, Issue3May 15, 1972Pages 343-346 ReferencesRelatedInformation

1972FEBS Letters（1972）引用：35

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