To examine the feasibility of a breast cancer-related lymphoedema (BCRL) screening programme. Additionally, to investigate the efficacy of bioimpedance analysis (BIA) compared to circumferential measurements (CM) in detecting BCRL.

This study aims to explore gynecological cancer survivors' perceptions and experiences following participation in a randomised controlled trial (RCT) testing the efficacy of a home-based physical activity behavioral change intervention (Donnelly et al., Gynecol Oncol 122:618–624, 2011).

OBJECTIVE:To determine the feasibility and efficacy of a physical activity behavioural change intervention in managing cancer-related fatigue among gynaecological cancer survivors during and post anti-cancer treatments. METHODS:A two arm, single blind, randomised controlled trial was conducted within the Northern Ireland regional Cancer Centre. Thirty three sedentary gynaecological cancer survivors (stage I-III; ≤3 years post diagnosis), experiencing cancer-related fatigue (mild-severe) took part. Participants were randomly assigned to a behavioural change, moderate intensity physical activity intervention (n=16) or a Contact Control group (n=17). The primary outcome was fatigue (Multidimensional Fatigue Symptom Inventory-Short Form and Functional Assessment in Chronic Illness Therapy-Fatigue subscale). Secondary outcomes included quality of life, physical functioning, positive and negative affect, depression, body composition, sleep dysfunction and self-reported physical activity. Feasibility was assessed based on the recruitment rate, programme and physical activity adherence and participants' programme evaluation, including optional focus groups (n=16). RESULTS:Twenty five percent of eligible women took part (33/134). Participants were 8.7 (SD=9.1) months post diagnosis, with a mean age of 53 (SD=10.3) years. The majority of the sample had a diagnosis of ovarian (n=12) or endometrial cancer (n=11). Significant differences favouring the intervention group were observed for fatigue at 12 weeks and 6 months follow-up (12 week: mean difference=-11.06; 95% confidence interval (CI)=-21.89 to -0.23; effect size (d)=0.13; p=0.046; 6 month: mean difference=-19.48; 95% CI=-19.67 to -19.15; effect size (d)=0.20; p=0.01). A mean of 10 calls (SD=1.2 calls) were delivered to the Physical Activity Group, and 10 (SD=1.6 calls) to the CC group. The intervention was positively perceived based on exit questionnaire and focus group findings. CONCLUSIONS:A physical activity behavioural change intervention for gynaecological cancer survivors is feasible in terms of participants' programme adherence and evaluation, and the intervention demonstrates improvements in fatigue. However, confirmation in the form of a larger fully powered RCT is warranted.

Objective To investigate the exercise barriers, facilitators and preferences of a mixed sample of cancer survivors as well as fatigue levels, quality of life (QoL) and the frequency and intensity of exercise that cancer survivors typically engage in. Methods An anonymous, postal questionnairesurvey with a convenience sample of 975 cancer survivors was used. Standardised measures were used to establish fatigue (Multidimensional Fatigue Symptom Inventory-Short Form), QoL (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30), exercise frequency and intensity (Leisure Score Index). Results A 52.3% response rate (n?=?456) was achieved. A total of 76.0% were female, with stage I (18.3%) or stage II (21.0%) breast cancer (64.4%), and 62.3% were =3?years post treatment. A total of 73.5% reported fatigue with 57.2% experiencing fatigue on a daily basis. A total of 68.1% had never been given any advice on how to manage fatigue. A total of 9.4% reported to engage in strenuous physical activity, 43.5% in moderate physical activity and 65.5% in mild physical activity. Respondents experienced difficulties with emotional, cognitive and social functioning and the symptoms of fatigue, insomnia and pain. Barriers that interfered with exercise often/very often were mainly related to respondents' health and environmental factors. A total of 50.2% were interested in exercise and 52.5% felt able to exercise. Exercise facilitators, preferences and motivators provide some insight into cancer survivors' needs in terms of becoming more physically active. Conclusions Although cancer survivors continue to experience fatigue and QoL issues long after treatment completion, over half are willing and feel able to participate in exercise. Exercise barriers were mainly health related or environmental issues, however, the main barriers reported were those that had the potential to be alleviated by exercise. Copyright (c) 2011 John Wiley & Sons, Ltd.

Background Despite the evidence to support exercise as an effective management strategy for patients with cancer-related fatigue (CRF), many of the general cancer population are sedentary. Objective The aim of this study was to explore the barriers to and facilitators of exercise among a mixed sample of patients with CRF. Design An exploratory, descriptive, qualitative design was used. Methods Purposive sampling methods were used to recruit patients with CRF who were representative of the cancer trajectory, that is, survivors of cancer and patients in palliative care who were recently diagnosed and undergoing treatment. Focus group discussions were transcribed verbatim and analyzed using a grounded theory approach. Lower-level concepts were identified and ordered into subcategories. Related subcategories then were grouped to form the main categories, which were linked to the core category. Results Five focus groups were conducted with 26 participants. Within the core category of the cancer rehabilitation journey were 3 main categories: (1) exercise barriers, (2) exercise facilitators, and (3) motivators of exercise. Exercise barriers were mainly related to treatment side effects, particularly fatigue. Fatigue was associated with additional barriers such as physical deconditioning, social isolation, and the difficulty of making exercise a routine. Environmental factors and the timing of exercise initiation also were barriers. Exercise facilitators included an exercise program being group-based, supervised, individually tailored, and gradually progressed. Exercise motivators were related to perceived exercise benefits. Conclusions Individuals with CRF have numerous barriers to exercise, both during and following treatment. The exercise facilitators identified in this study provide solutions to these barriers and may assist with the uptake and maintenance of exercise programs. These findings will aid physical therapists in designing appropriate exercise programs for patients with CRF.

Research papers NMR structural characterization of oligo-N-substituted glycine lead compounds from a combinatorial library / E.K. Bradley, J.M. Kerr, L.S. Richter, G.M. Figliozzi, D.A. Goff, R.N. Zuckermann, D.C. Spellmeyer and J.M. Blaney 1–15 Peptomers: A versatile approach for the preparation of diverse combinatorial peptidomimetic bead libraries / S. Østergaard and A. Holm 17–27 Composition and purity of combinatorial aryl ether collections analyzed by electrospray mass spectrometry / W.J. Haap, J.W. Metzger, C. Kempter and G. Jung 29–41 Limitations of the coupling of amino acid mixtures for the preparation of equimolar peptide libraries / J.A. Boutin, I. Gesson, J.-M. Henlin, S. Bertin, P.-H. Lambert, J.-P. Volland and J.-L. Fauchère 43–60 High throughput analysis and purification in support of automated parallel synthesis / H.N. Weller, M.G. Young, S.J. Michalczyk, G.H. Reitnauer, R.S. Cooley, P.C. Rahn, D.J. Loyd, D. Fiore and S.J. Fischman 61–70 Instructions to Authors 71–74

Dual representation of peptide and non-peptide structures in a chemical database as atomic-level molecular graphs and sequence strings permits chemical substructure and similarity searches as well as sequence-based substring and regular expression searches. CHUCKLES interconverts monomer-based sequences with SMILES, which represent atomic-level molecular graphs. Forward-translation maps peptide or other sequences into SMILES. Back-translation extracts monomer sequences from SMILES. This approach permits a generalized representation of monomers allowing user specification of any monomer. CHUCKLES allows mixing of atoms with user-defined monomer names; that is, monomer representation is consistent with SMILES notation. In addition, oligomer branching and cyclization are handled.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

The benzodiazepine (BZD) peptidomimetic I has been substituted for the naturally occurring four amino acid beta-turn in cyclo-(Gly-Pro-dPhe-dAla)2 and shown by NMR structural analysis to retain the double beta turn conformation in the resulting cyclic octapeptide, cyclo-(Gly-Pro-dPhe-dAla-BZD). This supports the proposal that the benzodiazepine scaffold is a useful beta-turn mimetic that preserved both the geometry of the turn and the positioning of the sidechains.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInformVolume 19, Issue 46 Reviews ChemInform Abstract: Molecular Modeling and Drug Design: Strategies in the Design and Synthesis of Phospholiphase A2 Inhibitors W. C. RIPKA, W. C. RIPKA Du Pont de Nemours&Co., Inc., Med. Prod. Dep., Wilmington, DE 19898, USASearch for more papers by this authorW. J. SIPIO, W. J. SIPIO Du Pont de Nemours&Co., Inc., Med. Prod. Dep., Wilmington, DE 19898, USASearch for more papers by this authorJ. M. BLANEY, J. M. BLANEY Du Pont de Nemours&Co., Inc., Med. Prod. Dep., Wilmington, DE 19898, USASearch for more papers by this author W. C. RIPKA, W. C. RIPKA Du Pont de Nemours&Co., Inc., Med. Prod. Dep., Wilmington, DE 19898, USASearch for more papers by this authorW. J. SIPIO, W. J. SIPIO Du Pont de Nemours&Co., Inc., Med. Prod. Dep., Wilmington, DE 19898, USASearch for more papers by this authorJ. M. BLANEY, J. M. BLANEY Du Pont de Nemours&Co., Inc., Med. Prod. Dep., Wilmington, DE 19898, USASearch for more papers by this author First published: November 15, 1988 https://doi.org/10.1002/chin.198846359Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume19, Issue46November 15, 1988 RelatedInformation