A relationship has been reported by several research groups [1 - 4] between the density and shapes of nerve fibers in the cornea and the existence and severity of peripheral neuropathy. Peripheral neuropathy is a complication of several prevalent diseases or conditions, which include diabetes, HIV, prolonged alcohol overconsumption and aging. A common clinical technique for confirming the condition is intramuscular electromyography (EMG), which is invasive, so a noninvasive technique like the one proposed here carries important potential advantages for the physician and patient.A software program that automatically detects the nerve fibers, counts them and measures their shapes is being developed and tested. Tests were carried out with a database of subjects with levels of severity of diabetic neuropathy as determined by EMG testing. Results from this testing, that include a linear regression analysis are shown.

PURPOSE:For optimal vision, the ablation zone in photorefractive keratectomy should be centered over the entrance pupil. During ablation, the globe can be immobilized by the surgeon, with a suction ring around the corneoscleral limbus. Alternatively, the globe can be immobilized by patient fixation on a target, unassisted by the surgeon. We investigated which method results in better centration of the ablation zone over the entrance pupil, by using an objective, mathematical method to determine the ablation zone center.METHODS:Forty-eight eyes from 48 patients who underwent photorefractive keratectomy by the two techniques were studied retrospectively. The centers of the ablation zones were objectively determined by a weighted center of mass algorithm applied to the preoperative minus postoperative difference maps. The validity of the objective method was confirmed by comparison to subjective estimates of ablation zone centers made by independent human observers.RESULTS:The 19 eyes treated by surgeon fixation had an average decentration of the ablation zone of 0.63 +/- 0.31 mm (range, 0.01 to 1.00 mm), and the 29 eyes treated by patient fixation had an average decentration of 0.41 +/- 0.23 mm (range, 0.11 to 1.18 mm) (P = .027).CONCLUSIONS:The center of the ablation zone can be determined mathematically from the topographic map, to avoid observer bias. In this study, unassisted patient fixation during photorefractive keratectomy produced more accurate centration of the ablation zone than did surgeon fixation and has the potential for maximizing the quality of vision postoperatively.

Sixty-two eyes underwent excimer laser photorefractive keratectomy (PRK) for the correction of myopia at Cedars-Sinai-Medical-Center. The first group of 12 patients are presented with follow up data of ten months postoperatively. The second group of 50 patients are presented with follow up data of three months postoperatively. An in-depth comparison of pre and postoperative refractive data is presented. Comparisons between pre and postoperative corrected and uncorrected Snellen visual acuities are provided in order to asses the functional visual result of the procedure.

We studied Saturn II contact lenses in keratoconus patients who were intolerant to other available contact lenses. A total of 24 patients, who were followed for up to 15 months, participated in the study. Visual acuities improved significantly following fitting with the Saturn II contact lens; whereas only one eye in the series was correctable to 20/20 before fitting, eight eyes were corrected to 20/20 following fitting. A great number of lenses had to be replaced during the study because of deposit formation and tearing at the interface (rate of replacement: 0.52 lenses per eye per month). A variety of complications occurred during lens wear, resulting in only six eyes wearing the Saturn II lens at the close of the study (out of 46 eyes that had started wearing the lens). Discomfort due to tightness of the peripheral segment was the most common cause of lens discontinuation. We conclude that the Saturn II lens was inadequate for fitting patients with advanced keratoconus.