Aim: This controlled, prospective, randomized porcine study tests the hypothesis that high-dose hyperbaric oxygen (HDHBO2) compared with normobaric oxygen (NBO2) or standard-dose hyperbaric oxygen (SDHBO2), improves return of sustained spontaneous circulation (ROSC) after a normothermic, normobaric, 25-min, non-intervened-upon cardiopulmonary arrest. The study incorporated a direct mechanical ventricular assist device (DMVAD) for open chest continuous cardiac compressions (OCCC) to assist advanced cardiac life support (ACLS). The experiment demonstrates a dose response to oxygen concentration in the breathing mix used in resuscitative ventilation.Materials and methods: Male pigs (average 30 kg weight) underwent a 25-min, normothermic, non-intervened-upon cardiopulmonary arrest. Following arrest all animals were ventilated with 100% oxygen and were subjected to OCCC, incorporating DMVAD-aided ACLS. The animals so treated were randomized to be in one of three groups, with six animals in each group. The NBO2 group remained at 1.0 atmosphere absolute (ATA), while the SDHBO2 and HDHBO2 groups were initially placed at 1.9 and 4.0ATA, respectively. Uniform, but not American Heart Association (ANA) protocol, ACLS was maintained as needed over the ensuing 2 h for all animals in all groups. At the end of 2 h, the animals were euthanized.Results: Continuously sustained ROSC (mean arterial pressure >= 50mmHg at all times), without the need of the pump assist over the 2-h resuscitation attempt that followed the 25-min arrest, occurred in four out of six animals in the HDHBO2 group, and in none of the animals in the NBO2 or SBHBO2 groups (p <= 0.001).Conclusions: Our results show significantly sustained ROSC using HDHBO2 to resuscitate swine after a 25-min, non-intervened-upon, normothermic cardiopulmonary arrest. These results could not be achieved using NBO2 or SDHBO2. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Narrative Matters Health AffairsVol. 25, No. 2: Global Health Priorities The Nine O’Clock MeetingKaren DeSalvo, James Moises, and Joseph UddoPUBLISHED:March/April 2006No Accesshttps://doi.org/10.1377/hlthaff.25.2.483AboutSectionsView articleView Full TextView PDFPermissions ShareShare onFacebookTwitterLinked InRedditEmail ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions View articleTOPICSEmergency medical servicesHospitalsAcute care Loading Comments... Please enable JavaScript to view the comments powered by Disqus. DetailsExhibitsReferencesRelated Article MetricsCitations: Crossref 2 History Published online 1 March 2006 InformationCopyright 2006 by Project HOPE - The People-to-People Health Foundation, Inc.PDF downloadCited byProhibiting direct medical care by US military personnel in foreign disaster relief: arguments from the Ebola disaster19 May 2016 | Medicine, Conflict and Survival, Vol. 124Health Care Infrastructure in Post-Katrina New Orleans: A Status ReportThe American Journal of the Medical Sciences, Vol. 336, No. 2