To study the epidemiology and etiology characteristics of first imported Chikungunya fever case in Henan province, China, 2017. The patient was confirmed by Chikungunya virus (CHIKV) infected as CHIKV ribonucleotide was continuously detected in his serum specimens. BHK-21 cell line was used for virus isolation, the strain was named CHIKV/Henan001/2017. CHIKV/Henan001/2017 belonged to genotype ECSA. The highest ribonucleotide homology sequence of highly conserved region E1 with CHIKV/Henan001/2017 was hk02 strain (99.8%), who was an imported strain to Hong Kong, China, 2016. Epidemiological information and laboratory testing confirmed it was an imported Chikungunya fever case in Henan province, 2017. No secondary case has been reported.

寨卡病毒最早于1947年在乌干达恒河猴体内被发现[1],2007年首次有寨卡病毒暴发疫情的报道[2].寨卡病毒病是一种以发热、头痛、皮疹、结膜炎和关节痛为临床表现的急性自限性传染病.2015年5月以来,寨卡病毒在巴西大规模暴发流行,疫情传播至多个国家和地区,部分国家和地区出现了输入性病例从而引起本地感染的现象.同时,巴西新生儿小头畸形病例显著增加,多项证据显示新生儿小头畸形与母亲孕期感染寨卡病毒有关[3-5].WHO于2016年2月1日将寨卡病毒及小头症列为全球紧急公共卫生事件.2016年2月9日,中国疾病预防控制中心(Center for Disease Control and Prevention,CDC)确诊我国首例输入性寨卡病例.广东、浙江省等地相继也有输入性病例的报道[6-8].河南省首例输入性寨卡病例于2016年9月8日入境,河南省相关部门通力合作,采取隔离、随访监测等多项措施预防、控制输入性病例引起本地感染,现报告如下.

BACKGROUND/OBJECTIVES: Folic acid supplementation has been suggested to reduce the risk of preeclampsia. However, results from few epidemiologic studies have been inconclusive. We investigated the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk of preeclampsia.SUBJECTS/ METHODS: A birth cohort study was conducted in 2010-2012 at the Gansu Provincial Maternity & Child Care Hospital in Lanzhou, China. A total of 10 041 pregnant women without chronic hypertension or gestational hypertension were enrolled.RESULTS: Compared with nonusers, folic acid supplement users had a reduced risk of preeclampsia (OR = 0.61, 95% CI: 0.43-0.87). A significant dose-response of duration of use was observed among women who used folic acid supplemention during pregnancy only (P-trend = 0.007). The reduced risk associated with folic acid supplement was similar for mild or severe preeclampsia and for early-or late-onset preeclampsia, although the statistical significant associations were only observed for mild (OR = 0.50, 95% CI: 0.30-0.81) and late-onset (OR = 0.60, 95% CI: 0.42-0.86) preeclampsia. The reduced risk associated with dietary folate intake during pregnancy was only seen for severe preeclampsia (OR = 0.52, 95% CI: 0.31-0.87, for the highest quartile of dietary folate intake compared with the lowest).CONCLUSIONS: Our study results suggest that folic acid supplementation and higher dietary folate intake during pregnancy reduce the risk of preeclampsia. Future studies are needed to confirm the associations.