ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewHerbal Drugs Industry: A Practical Approach to Industrial Pharmacognosy Edited by R. D. Chaudhri (Consultant, Bombay, India). Eastern Publishers, New Delhi, India. 1996. xii + 648 pp. 18 × 23 cm. $200.00. ISBN 0-532-42154-5.James E. RobbersView Author Information Department of Medicinal Chemistry and Molecular Pharmacology Purdue University West Lafayette, Indiana 47907Cite this: J. Nat. Prod. 1997, 60, 11, 1218Publication Date (Web):November 21, 1997Publication History Published online21 November 1997Published inissue 1 November 1997https://pubs.acs.org/doi/10.1021/np970095rhttps://doi.org/10.1021/np970095rbook-reviewACS PublicationsCopyright © 1997 American Chemical Society and American Society of PharmacognosyRequest reuse permissionsArticle Views115Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Mathematical methods,Oscillation,Pharmaceuticals,Quantum mechanics,Spectroscopy Get e-Alerts
【The carpophores of Cryptoporus volvatus collected in Gyeong-gi Province of Korea were extracted with water and a protein-polysaccharide fraction was obtained after dialysis and lyophilization. The antitumor activity of this fraction was tested against sarcoma 180 implanted in A-strain mice. The tumor inhibition ratio was 80.4% in case of the high dose group (50mg/kg, ip, 10 days) and 70.3% in the low dose group (20mg/kg, ip, 10 days). The proteinpolysaccharide fraction was chemically analyzed and was found to be a complex of a protein which was 18.2% of the fraction when determined by Lowry-Folin method, and a polysaccharide which was 55.3% of ther fraction when determined by Anthrone method. Their subunits were identified as four monosaccharides and 18 amino acids by gas-liquid chromatography and amino acid autoanalysis.】
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhysiological Studies on Ergot. The Induction of Ergot Alkaloid Biosynthesis by the Tryptophan Bioisosteres, β-1- and β-2-NaphthylalanineJames E. Robbers, Suthinee Srikrai, Heinz G. Floss, and Hans G. SchlossbergerCite this: J. Nat. Prod. 1982, 45, 2, 178–181Publication Date (Print):March 1, 1982Publication History Published online1 July 2004Published inissue 1 March 1982https://doi.org/10.1021/np50020a011RIGHTS & PERMISSIONSArticle Views103Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (259 KB) Get e-Alerts Get e-Alerts
This chapter focuses on the regulation of ergot alkaloid formation, and the influence of tryptophan and its analogs and of the end product elymoclavine. The induction of alkaloid synthesis by tryptophan is a complex process. The exposure to tryptophan must occur early during the growth phase when no alkaloid is formed. Time-course studies show that full induction requires addition of tryptophan during the first 24 h of the fermentation and that a 12 h exposure period is sufficient. It seems likely that the gene expression programmed in some way by tryptophan is still suppressed during the growth phase, for example, by some form of catabolite repression. The inorganic phosphate present in the medium may exert such a repression, as it is known that in the presence of increased levels of phosphate the alkaloid synthesis is almost completely abolished.
Biosynthesis of ergot alkaloids is discussed from the standpoint of biosynthetic precursors and intermediates as well as known biosynthetic mechanisms. Emphasis is given to work concerning regulation of alkaloid production, including the role of tryptophan as an inducer of alkaloid synthesis. A postulation is proposed to explain the significance of induction in terms of evolution and survival of the organism which also takes into account the finding that the biosynthesis of tryptophan is under regulatory control in the fungal strain which was investigated. Recent studies using protoplasts of ergot have also shown that endproduct regulation of alkaloid synthesis may be a significant phenomenon.
Luteoskyrin, a toxic metabolite ofPenicillium islandicum can be isolated by an acetone-Silica Gel chromatography column. A preliminary procedure separates the luteoskyrin and 2 other similar metabolites from the mycelial mat. The column used has the advantage of eluting the luteoskyrin as the first band from the source. A thin layer system utilizing CaHPO4 as stationary phase is also available to separate the components of the column and to verify isolation of luteoskyrin.
