A 22-year-old man was ejected from his vehicle sustaining traumatic brain injury, facial fractures, pulmonary contusions, liver laceration, and adrenal hemorrhage. Best-corrected visual acuity was 20/40 in the right eye and hand motions in the left eye. Fundoscopy and color photographs showed numerous cloud-like cotton wool spots surrounding the optic disc bilaterally, and classic intraretinal whitening with clear zones adjacent to the retinal vasculature as seen in the macula of the left eye. Purtscher's retinopathy is an occlusive microangiopathy associated with severe head trauma.