Commercializing knowledge involves transfer from discovering scientists to those who will develop it commercially. New codes and formulae describing discoveries develop slowly-with little incentive if value is low and many competing opportunities if high. Hence new knowledge remains naturally excludable and appropriable. Team production allows more knowledge capture of tacit, complex discoveries by firm scientists. A robust indicator of a firm's tacit knowledge capture (and strong predictor of its success) is the number of research articles written jointly by firm scientists and discovering, “star” scientists, nearly all working at top universities. An operationally attractive generalization of our star measure-collaborative research articles between firm scientists and top research university scientists-replicates the impact on firm success. In panel analyses, publications by firm scientists with stars and/or top 112 university scientists increase the number and citation rate for firm patents. Further, star articles increase these rates significantly more than other top 112 university scientists' articles. Cross-sectional analyses of products and employment show a similar pattern of positive effects on firms' success of collaborations with stars or top university scientists, but estimates of differential effects are nonrobust due to multicollinearity. Venture capital funding has significant, usually positive effects on firm success.

Using detailed data on California biotechnology, we find that the positive impact of research universities on nearby firms relates to identifiable market exchange between particular university star scientists and firms and not to generalized knowledge spillovers. Poisson and two-stage Heckman regressions indicate the number of star-firm collaborations powerfully predicts success: for an average firm, five articles coauthored by academic stars and the firm's scientists imply about five more products in development, 3.5 more products on the market, and 860 more employees. Stars collaborating with or employed by firms, or who patent, have significantly higher citation rates than pure academic stars.

We examine the effects of university-based star scientists on three measures of performance for California biotechnology enterprises: the number of products in development, the number of products on the market, and changes in employment. The `star' concept which Zucker, Darby, and Brewer (1994) demonstrated was important for birth of U.S. biotechnology enterprises also predicts geographically localized knowledge spillovers at least for products in development. However, when we break down university stars into those who have collaborated on publications with scientists affiliated with the firm and all other university stars, there is a strong positive effect of the linked stars on all three firm-performance measures and little or no evidence of an effect from the other university stars. We develop a new hypothesis of geographically localized effects of university research which is consistent with market exchange: Geographically localized effects occur for scientific discoveries characterized by natural excludability, those which can be learned only by working with discoverers or others who have received the knowledge through working together in the laboratory. Natural excludability results in intellectual capital, a transitory form of human capital, embodied in particular scientists whose services must be employed in order to practice the discovery. Contractual and/or ownership relationships occur between firms and the university scientists with intellectual capital and importantly determine firm productivity and growth.

We examine the effects of university-based star scientists on three measures of performance for California biotechnology enterprises: the number of products in development, the number of products on the market, and changes in employment. The “star” concept which Zucker, Darby, and Brewer (1994) demonstrated was important for birth of US. biotechnology enterprises also predicts geographically localized knowledge spillovers at least for products in development. However, when we break down university stars into those who have collaborated on publications with scientists affiliated with the firm and all other university stars, there is a strong positive effect of the linked stars on all three firm-performance measures and little or no evidence of an effect from the other university stars. We develop a new hypothesis of geographically localized effects of university research which is consistent with market exchange: Geographically localized effects occur for scientific discoveries characterized by natural excludability, those which can be learned only by working with discoverers or others who have received the knowledge through working together in the laboratory. Natural excludability results in intellectual capital, a transitory form of human capital, embodied in particular scientists whose services must be employed in order to practice the discovery. Contractual and/or ownership relationships occur between firms and the university scientists with intellectual capital and importantly determine firm productivity and growth.

Author(s): Zucker, Lynne G.; Darby, Michael R.; Armstrong, Jeff | Abstract: We examine the effects of university-based star scientists on three measures of performance for California biotechnology enterprises: the number of products in development, the number of products on the market, and changes in employment. The “star” concept which Zucker, Darby, and Brewer (1994) demonstrated was important for birth of US. biotechnology enterprises also predicts geographically localized knowledge spillovers at least for products in development. However, when we break down university stars into those who have collaborated on publications with scientists affiliated with the firm and all other university stars, there is a strong positive effect of the linked stars on all three firm-performance measures and little or no evidence of an effect from the other university stars.We develop a new hypothesis of geographically localized effects of university research which is consistent with market exchange: Geographically localized effects occur for scientific discoveries characterized by natural excludability, those which can be learned only by working with discoverers or others who have received the knowledge through working together in the laboratory. Natural excludability results in intellectual capital, a transitory form of human capital, embodied in particular scientists whose services must be employed in order to practice the discovery. Contractual and/or ownership relationships occur between firms and the university scientists with intellectual capital and importantly determine firm productivity and growth.