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A series of rhodium pyrazolylborate complexes [TpRRh(PPh3)2] {TpR = HBR‘3, R‘ = 3,5-dimethylpyrazolyl (1), pyrazolyl (3), 3-phenylpyrazolyl (4), or 3-phenyl-5-methylpyrazolyl (5)} and [BpRRh(PPh3)2] {BpR = H2BR‘2, R‘ = 3,5-dimethylpyrazolyl (2)} were prepared from [ClRh(PPh3)3] and KX (X = pyrazolylborate anion). Complexes 2−5 were characterized crystallographically. The solution structures of new complexes 4 and 5 were also examined by variable temperature NMR and IR spectroscopy. The catalytic activity of complexes 1−5 in alkyne hydrothiolation was then examined. It was found that disubstituted tris(pyrazolyl)borate complexes (1 and 5) give the best selectivity and yield in alkyne hydrothiolation with aliphatic thiols.

Previously we described joining of DNA in the beta-T cell receptor gene to DNA of an uncharacterized locus in a t(7;9)(q34;q34.3) chromosomal translocation from a case of human T lymphoblastic leukemia (T-ALL). We now show that the locus on chromosome 9 contains a gene highly homologous to the Drosophila gene Notch. Transcripts of the human gene, for which we propose the name TAN-1, and its murine counterpart are present in many normal human fetal and adult mouse tissues, but are most abundant in lymphoid tissues. In t(7;9)(q34;q34.3) translocations from three cases of T-ALL, the breakpoints occur within 100 bp of an intron in TAN-1, resulting in truncation of TAN-1 transcripts. These observations suggest that TAN-1 may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms.

Immunological ReviewsVolume 96, Issue 1 p. 43-58 Somatic Mutation in Human B-Cell Tumors Ronald Levy, Ronald Levy Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorShoshana Levy, Shoshana Levy Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorMichael L. Cleary, Michael L. Cleary Department of Pathology, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorWilliam Carroll, William Carroll Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorShinichiro Kon, Shinichiro Kon Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorJeffrey Bird, Jeffrey Bird Department of Pathology, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorJeffrey Sklar, Jeffrey Sklar Department of Pathology, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this author Ronald Levy, Ronald Levy Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorShoshana Levy, Shoshana Levy Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorMichael L. Cleary, Michael L. Cleary Department of Pathology, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorWilliam Carroll, William Carroll Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorShinichiro Kon, Shinichiro Kon Department of Medicine, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorJeffrey Bird, Jeffrey Bird Department of Pathology, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this authorJeffrey Sklar, Jeffrey Sklar Department of Pathology, Standford Medical School, Stanford, California, USA 94305.Search for more papers by this author First published: April 1987 https://doi.org/10.1111/j.1600-065X.1987.tb00508.xCitations: 76AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. 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