目的 探讨精神分裂症患者ABCB1基因多态性与经奥氮平治疗后体重、血糖、血脂变化的相关性.方法 前瞻性入组2017年7月至2018年12月住院的精神分裂症患者72例,单一服用奥氮平.采用Taqman探针基因分型技术对ABCB1基因rs1045642、rs2032582多态性进行分型.应用重复测量方差分析比较ABCB1基因rs1045642、rs2032582位点不同基因型间在基线期、治疗8周后体重、血糖、总胆固醇、甘油三酯、高密度脂蛋白(HDL)、低密度脂蛋白水平变化的差异.结果 rs1045642位点CC基因型患者治疗后较基线期体重增加、空腹血糖下降,差异均有统计学意义[分别为(62.76±9.42)kg比(58.95±12.03)kg,t=10.040,P<0.05;(5.08±1.28)mmol/L比(6.33±2.38)mmol/L,t=7.268,P<0.05],而CT、TT基因型患者治疗前后差异均无统计学意义(均P>0.05);rs1045642位点CC、TT基因型治疗后较基线期HDL下降[分别为(1.12±0.30)mmol/L比(1.31±0.57)mmol/L,t=6.530,P<0.05;(1.36±0.23)mmol/L比(1.54±0.19)mmol/L,t=10.161,P<0.05],差异均有统计学意义,而CT基因型治疗前后差异无统计学意义(P>0.05).rs2032582位点GG、TT基因型治疗后较基线期体重均增加[(62.57±10.61)kg比(59.23±12.20)kg,t=6.159,P<0.05;(60.19±6.93)kg比(57.31±8.97)kg,t=5.188,P<0.05],差异有统计学意义,GT基因型治疗前后差异无统计学意义(P>0.05);GG基因型治疗后较基线期血糖、HDL下降[分别为(5.19±1.39)mmol/L比(6.44±2.56)mmol/L,t=5.220,P<0.05;(1.18±0.30)mmol/L比(1.39±0.58)mmol/L,t=5.576,P<0.05],差异均有统计学意义,而GT、TT基因型治疗前后差异均无统计学意义(均P>0.05).结论 ABCB1基因多态性可能与精神分裂症患者经奥氮平治疗后体重增加、血脂代谢异常有相关性.

Depression has caused great harm to people's physical and mental health. The existing western antidepressants can not meet the needs of all patients. The role of traditional Chinese medicine prescriptions and medicines in the treatment of depression has aroused widespread concern. This article summarizes several currently used traditional Chinese medicine formulas and reviews their clinical efficacy and mechanism of action.

Objective:To explore the effect of applying the diversified art therapy in the rehabilitation of patients with schizophrenia. Methods:134 patients with schizophrenia were randomly divided into the observation group and the control group(67 cases in each group). The patients in both groups were given conventional treatment in hospital. The patients in the control group received routine enter-tainment treatment and nursing care and the patients in the observation group were additionally given the diversified art therapy,the scores of SDSS,SCL - 90 and life quality of the patients were compared between the two groups after the intervention. Results:The scores of SDSS,SCL - 90 and life quality of the patients were lower in the observation group than those in the control group after the intervention (P ﹤ 0. 05). Conclusion:Application of the diversified art therapy in the rehabilitation of patients with schizophrenia can improve the social function,alleviate symptoms and improve the quality of life of the patients.

Objective:To explore the efficacy and safety of olanzapine and risperidone to treat the behavioral and psychological symptoms of dementia(BPSD). Method:67 patients with Alzheimer disease or vascular dementia were studied.34 treated with olanzapine and 33 treated with risperidone.The study persisted 8 weeks.Behavioral pathology in Alzheimer disease rating scale(Behave AD),Cohen-mansfield agitation inventory(CMAI)and treatment emergent sympotom scale(TESS)were used. Results:The Behave AD and CMAI scores in both groups decreased significantly after treatment(all P<0.01).Both drugs had few side effects. Conclusion:Olanzapine and risperidon have good efficacy in the treatment of BPSD with small dosage and few side effects,the two drugs had equal efficacy.

阿尔茨海默病(Alzheimer's disease,AD)是以脑的广泛神经细胞脱落、神经细胞外老年斑(senile plague,SP)沉积和胞内神经原纤维缠结(neurofibril-lary tangles,NFT)为主要病理改变的神经退变性疾病.临床表现为进行性精神状态衰变,包括记忆、智力、定向、判断能力、情感障碍和行为失常甚至发生意识模糊等.AD严重地威胁老年人的身心健康,是老龄化社会的沉重负担.