The editors greatly appreciate the support of all reviewers whose comments and scientific evaluation of submitted manuscripts are invaluable for ensuring the scientific quality of this journal. In addition to the listed permanent members of the board of Reviewing Editors, the following distinguished clinicians and scientists acted as reviewers for Neuroendocrinology from the beginning of November 2010 to the end of October 2011. The Editors hereby express their sincere gratitude for and their appreciation of the work done as well as the support given to this journal.

Regular Members. Membership in the ISNN is open to researchers, educators and clinicians, who have a continuing scientific interest in Nutrition and/ or Genetics/Molecular Biology/Pharmacology. Regular members pay full annual dues, may nominate and vote in Society elections, may hold elected and appointed offices, may serve on committees, receive discounted registration for Society Congresses, and receive a complimentary subscription to the Journal of Nutrigenetics and Nutrigenomics: Official Journal of the ISNN, edited by Jing X. Kang, M.D., Ph.D. (USA). Student Members must be students, trainees or post-doctoral fellows and may continue in student status for up to three years. Applicants must attach a letter from their institution or supervisor certifying their status. Student Members pay reduced annual membership dues, may vote in Society matters, receive discounted registration to Society Congresses, serve on Committees and enjoy members-only privileges. Student Members receive an online-only subscription to the Society’s official journal. Please return this application to: S. Karger AG Medical and Scientific Publishers Attn: Mr. Peter Roth Allschwilerstrasse 10 CH–4009 Basel (Switzerland) Tel. +41 61 306 1111 Fax +41 61 306 1234 E-mail p.roth@karger.com

Regular Members. Membership in the ISNN is open to researchers, educators and clinicians, who have a continuing scientifi c interest in Nutrition and/ or Genetics/Molecular Biology/Pharmacology. Regular members pay full annual dues, may nominate and vote in Society elections, may hold elected and appointed offi ces, may serve on committees, receive discounted registration for Society Congresses, and receive a complimentary subscription to the Journal of Nutrigenetics and Nutrigenomics: Offi cial Journal of the ISNN, edited by Jing X. Kang, M.D., Ph.D. (USA). Student Members must be students, trainees or post-doctoral fellows and may continue in student status for up to three years. Applicants must attach a letter from their institution or supervisor certifying their status. Student Members pay reduced annual membership dues, may vote in Society matters, receive discounted registration to Society Congresses, serve on Committees and enjoy members-only privileges. Student Members receive an online-only subscription to the Society’s offi cial journal. Please return this application to: S. Karger AG Medical and Scientifi c Publishers Attn: Mr. Peter Roth Allschwilerstrasse 10 CH–4009 Basel (Switzerland) Tel. +41 61 306 1111 Fax +41 61 306 1234 E-mail p.roth@karger.ch

Michel de Lorgeril, Grenoble Lynnette R. Ferguson, Auckland Serge Ferrari, Geneva Ronald Krauss, Oakland, Calif. Renato Mariani-Constantini, Chieti Alfredo Martínez, Pamplona John A. Milner, Rockville, Md. Sergio Muntoni, Cagliari Marjanne Senekal, Cape Town Charles N. Serhan, Boston, Mass. Gérard Siest, Nancy Antonio Velazquez, Mexico City Nikos Yiannakouris, Athens Aims and Scope The purpose of the society is to increase understanding through research and education of professionals and the general public of the role of genetic variation and dietary response and the role of nutrients in gene expression.

Omega-3 polyunsaturated fatty acids (\#969;3-PUFAs) are known to inhibit cancer cells proliferation in animal models and cell lines; in contrast, \#969;6-PUFAs promote the growth of cancer cells. However, the molecular mechanisms remain to be further understood. This study was designed to investigate action mechanisms of \#969;3-PUFAs, especially docosahexaenoic acid (DHA), on inhibition of invasion, tumorigenicity, angiogenesis and metastasis in breast cancer. DHA suppressed motility and invasion of MDA-MB-231 cells in a dose-dependent manner; in contrast, AA has no effect. In gelatin embedded zymography, activities of MMP-2 and MMP-9 were decreased by DHA treatment and the levels of their mRNA were also decreased in dose-dependent manner. MMP-2 and MMP-9 promoter activity were inhibited after DHA treatment. The levels of VEGF protein and its promoter activity were inhibited by DHA treatment. AA- and PGE2-induced VEGF promoter activity was also inhibited by DHA pretreatment. The level of NF-kB protein and binding activities of NF-\#954;B and AP-1 were decreased by DHA treatment. DHA inhibited NF-kB and Cox-2 reporter activities and PGE2-dependent increases of their promoter activities were also inhibited by DHA pretreatment. When mouse breast cancer E0771 cells were implanted into Fat1 mice (Fat1 transgenic mice express a Caenorhabditis elegans \#969;3-desaturase converting \#969;6- to \#969;3-PUFAs endigenously.), tumor size and volume were significantly reduced in Fat1 transgenic mice compared with wild mice. In immunohistochemical analysis of tumors of Fat1 mice, apoptotic cells were markedly increased and angiogenesis significantly was reduced, compared with wild mice tumor. Binding activites of NF-kB and AP-1 were decreased in Fat1 mice tumors. When E0771 cells were injected through tail vein, lung metastasis of breast cancer cells was significantly inhibited in Fat1 transgenic mice. These findings suggest that \#969;3-PUFAs may inhibit tumor invasion, tumorigenicity, angiogenesis, and metastasis by decrease of MMPs activities and VEGF level via reduction of NF-kB and AP-1 in breast cancer. Thus, utilization of \#969;3-PUFAs may represent an effective and safe therapeutic approach for the chemoprevention and treatment of human breast cancer. [This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2007-521-E00014), Yihang Scholarship Foundation of Chungnam National University Medical School, and Dr. Park\#8217;s Breast Clinic, Korea]. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3749.

Michel de Lorgeril La Tronche (Grenoble) Serge Ferrari Geneva Steve Humphries London Jing X. Kang Charlestown, Mass. Ronald Krauss Oakland, Calif. Sergio Muntoni Cagliari Gérard Siest Nancy Marjanne Senekal Cape Town Lisa A. Spence Rosemont, Ill. Antonio Velazquez Mexico City Nikos Yiannakouris Athens Aims and Scope The purpose of the society is to increase understanding through research and education of professionals and the general public of the role of genetic variation and dietary response and the role of nutrients in gene expression.