Background Gallbladder mucocele is a potentially life-threatening extrahepatic biliary disease in dogs. The primary aims of this study were to evaluate the prevalence of cholecystitis in dogs with gross and histopathologically confirmed gallbladder mucocele and to investigate if there is an association between cholecystitis, including its subtypes (eg, acute, acute on chronic, with necrosis, chronic), and survival. Our secondary objective was to evaluate if there is an association between cholecystitis and intraoperative bacteriological culture positivity. Key Findings Two hundred nineteen dogs with gallbladder mucocele were included in this multi-institutional retrospective study, of which 63 (28.8%) dogs had histopathological evidence of cholecystitis. The most common forms of cholecystitis were acute on chronic (n = 22/63, 34.9%) and with necrosis (n = 20, 31.7%). Thirty-one (14.1%) dogs had growth of at least 1 bacterial isolate; however, 88.7% had antimicrobials administered within the 48 hours before surgery or intraoperatively. There was not an association between cholecystitis or its subtypes and survival. Furthermore, there was not an association between cholecystitis and intraoperative bacteriological culture positivity. A total of 38 (17.4%) dogs either died or were euthanized during hospitalization. Significance Cholecystitis is a common comorbidity in dogs with gallbladder mucocele but was not associated with decreased survival.

Background: Gallbladder mucocele (GBM) is an increasingly recognized extrahepatic biliary disease in dogs. Objectives: To investigate cases of GBM and identify variables associated with survival and the sensitivity and specificity of ultrasonography to identify gallbladder rupture. Animals: Two hundred and nineteen client-owned dogs with GBM. Methods: Multicenter, retrospective study of dogs with GBM, presented from January 2007 to November 2016 to 6 academic veterinary hospitals in the United States. Interrogation of hospital databases identified all cases with the inclusion criteria of a gross and histopathologic diagnosis of GBM after cholecystectomy and intraoperative bacteriologic cultures of at least 1 of the following: gallbladder wall, gallbladder contents, or abdominal effusion. Results: Two hundred and nineteen dogs fulfilled the inclusion criteria. Dogs with GBM and gallbladder rupture with bile peritonitis at the time of surgery were 2.7 times more likely to die than dogs without gallbladder rupture and bile peritonitis (P = 0.001; 95% confidence interval [CI], 1.50-4.68; n = 41). No significant associations were identified between survival and positive bacteriologic cultures, antibiotic administration, or time (days) from ultrasonographic identification of GBM to the time of surgery. The sensitivity, specificity, positive, and negative likelihood ratios for ultrasonographic identification of gallbladder rupture were 56.1% (95% CI, 39.9-71.2), 91.7% (95% CI, 85.3-95.6), 6.74, and 0.44, respectively. Conclusion and Clinical Importance: Dogs in our study with GBM and intraoperative evidence of gallbladder rupture and bile peritonitis had a significantly higher risk of death. Additionally, abdominal ultrasonography had low sensitivity for identification of gallbladder rupture.

OBJECTIVE:To describe a suture-free technique for canine ureteral resection-anastomosis using a microvascular anastomotic system (MAS) and to compare surgical time and burst pressure of hand-sewn (HS) ureteral end-to-end anastomosis with the MAS technique.STUDY DESIGN:Experimental ex vivo study.ANIMALS:Canine cadavers (n = 8).METHODS:For each cadaver, 1 ureter was randomly assigned to undergo HS anastomosis and the contralateral ureter had MAS anastomosis. The first 3 cadavers (6 ureters) were used to refine the MAS technique. In the other 5 dogs, surgical time and ureteral burst pressure were compared between groups (n = 5 ureters/group).RESULTS:Preliminary procedures showed that selective impaling of the mucosa and submucosa (without muscularis and adventitia) is necessary to allow complete mechanical interlock of the anastomotic rings for the MAS technique. Median anastomotic time was significantly shorter for MAS (7.6 min) than HS (16.6 min; p = .029) and burst pressure higher for MAS (393 cm H2 O) than HS (180 cm H2 O; p = .012).CONCLUSION:This study demonstrated the feasibility of a suture-free technique of canine ureteral resection-anastomosis using a commercially available MAS. The MAS anastomosis was faster and had higher burst strength compared with the HS anastomosis.

OBJECTIVE:Evaluate effect of adding drop wires to single-ring constructs.STUDY DESIGN:Biomechanical studySAMPLE POPULATION:Single ring circular external skeletal fixator constructs stabilizing a Delrin segment bone model.METHODS:Eight replicates of 5 constructs made with 66 mm complete rings, 1.6 mm olive wires, and a 15.9-mm diameter Delrin rod were loaded in axial compression, craniocaudal and mediolateral bending, and torsion. Constructs tested were: (1) base single-ring construct; (2) single-ring construct with a drop wire mounted on fixation bolts; (3) single-ring construct with a drop wire mounted on 1-hole posts; (4) single-ring construct with a drop wire mounted on 2-hole posts; and (5) 2-ring construct. Construct stiffness for each mode of loading was compared using repeated measures ANOVAs (P ≤ .05).RESULTS:Axial compression and torsion: the 2-ring construct was stiffer than all others. Drop wire constructs were stiffer than the single-ring construct, but not significantly different from each other. Craniocaudal bending: the 2-ring construct was stiffest with the 2-hole post construct being stiffer than all except the 2-ring construct. Mediolateral bending: the 2-hole post construct was stiffer than the 2-ring construct, which was stiffer than the 1-hole post construct, which was stiffer than the fixation-bolt construct, which was stiffer than the single-ring construct.CONCLUSIONS:Drop wires improved stiffness of single-ring constructs in all loading modalities. Positioning the drop wire farther from the ring surface significantly improved craniocaudal and mediolateral bending stiffness, but did not affect axial compression and torsional stiffness.