OBJECTIVE To investigate patients for positive culture rates with or without infection retardant coatings (IRC) penile prostheses (PPs) and to examine changes in culture positive isolates found in patients presenting overt clinical infection. METHODS Cultures were obtained from PPs immediately upon surgical exposure of the pump. 236 patients were broken down into 2 groups, with each further divided into 2 groups. The noninfected group included 208 patients: 133 with uncoated PPs and 75 with IRC implants. The infected group included 28 patients: 16 with uncoated PP and 12 with IRC inflatable penile prostheses (IPP). Additionally, sensitivity to the combination of tetracycline and rifampin were evaluated on all cultures. RESULTS In the noninfected group, culture positive isolates were found in 85 patients with uncoated PP's and in 32 patients with IRC implants [P value = 0.0003]. Cultures positive for Staphylococcus genus were found in 75 uncoated PP patients, while 20 patients with IRC implants had an isolate of this genus. In the infected group, culture positive isolates were found in 7 patients with uncoated PP and 6 patients with IRC IPPs [P value = 1.000]. Positive cultures for Staphylococcus genus were found in 6 patients with uncoated PP, while 3 patients with IRC IPP had an isolate of this genus. All bacterial isolates were sensitive to the combination of tetracycline and rifampin. CONCLUSION Positive bacterial cultures have been shown to be present on clinically uninfected IPPs at time of revision surgery. Culture isolates grown from patients with IRC IPPs reveal a nontraditional bacterial profile: fewer cultured isolates of Staphylococcus genus. (C) 2018 Elsevier Inc.

The works were selected by the type of study, the group of patients, the type of intervention, and by comparing the outcome.The studies consisted of comparative studies or clinical trials in English, Portuguese or Spanish.Patients were included only obese male with no other restriction of age, race or sexual orientation.The selected interventions were bariatric surgery, regardless of whether this was restrictive, disabsorptive or mixed.The comparisons were accepted confronting study patients before and after bariatric surgery.Accepted outcomes assessed improvement of erectile dysfunction or sexual function of men, using International Index of Erectile Function Questionnaire (IIEF).The SING checklist for comparative studies were used in order to evidence the limitations and biases of each article.It was used for the meta-analysis RevMan 5.3 software of the Cochrane Library.RESULTS: Articles recovered in the MedLine 16, Lilacs 12, Central 22, Cochrane 22, Scopus 34 and CINAHL 26.It was not rescued any item from the search text books, theses and references to other articles.These were used for the complete reading 8 and the meta-analysis 5.Patients undergoing BS had an increased IIEF Erectile Function scores of 3% of 5.24 points (95% CI -6.93, -3.54) with a I 2 ¼ 0% (Figure 1).In Sexual Desire increased by 1 point (95% CI -1.58, -0.41) with a I 2 ¼ 74%.In Intercourse Satisfaction of 2.62 points (95% ISC, -4.04, -1.20) with a I 2 ¼ 90%., all with statistical significance.The Orgasmic Function and the Overall Satisfaction were increased 0.14 points (95% CI -0.99, 0.71) with a I 2 ¼ 0% and 4.89 points (95% CI -11.17, 1.40) with a I 2 ¼ 14%, respectively, but without statistical significance.CONCLUSIONS: Bariatric surgery improves erectile function in obese patients.

In 1995, Licht et al introduced the idea that organisms found at removal and replacement of an IPP for non-infectious reasons were subsequently responsible for those found at later IPP infection if it occurred. Three of their culture positive patients later became infected and higher colony counts of the same organism were found at time of explantation. None of their IPP patients with a negative culture at reoperation developed a subsequent prosthetic infection. This is the only study to our knowledge that compares cultures at removal and replacement with cultures at later surgery. We reviewed our series of similar surgical IPP patients undergoing removal and replacement to see if this remains true today. We identified 304 patients at our four institutions that had undergone revision of an IPP between 2001 and 2012. Eleven later underwent another IPP revision surgery and additional cultures were drawn. Complications leading to revision surgery included mechanical failure (6), autoinflation (1), floppy glans (1), hematoma formation (1), loss of fluid (1), and retained components (1). These patients later underwent IPP revision surgery for: infection (7), autoinflation (2), bladder laceration (1), and erosion (1).

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Peyronie Disease + Surgical Therapy1 Apr 20131663 INFECTION RETARDANT COATED VERSUS NON-COATED PENILE PROSTHESIS CULTURES DURING REVISION SURGERY: A MULTICENTER STUDY Gerard Henry, Chris Smith, Steven Wilson, John Delk, Mario Cleves, Caroline Jennermann, and Culley Carson Gerard HenryGerard Henry Shreveport, LA More articles by this author , Chris SmithChris Smith Shreveport, LA More articles by this author , Steven WilsonSteven Wilson Palm Springs, CA More articles by this author , John DelkJohn Delk Little Rock, AR More articles by this author , Mario ClevesMario Cleves Little Rock, AR More articles by this author , Caroline JennermannCaroline Jennermann Shreveport, LA More articles by this author , and Culley CarsonCulley Carson Chapel Hill, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.3077AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previously published papers have shown that the majority of clinically uninfected penile prostheses have organisms growing in the implant spaces at reoperation (J Urol 172: 153, 2004). Virtually all 3-piece penile prostheses (IPP) placed in the United States have infection retardant coatings; InhibiZone on the American Medical Systems 700 series and Titan hydrophilic coating on the Coloplast Titan series. These coated penile prostheses appear to reduce infection rates by close to half in published studies in primary implantation. However, these infection retardant coated prostheses have not been shown to reduce revision/replacement infection rates without the addition of a revision washout (J Urol 173: 89, 2005). This is the first investigation of whether these infection retardant coated implants have lower cultures rates at the time of clinically uninfected revision surgery as compared to penile prostheses without coating. METHODS At four institutions, cultures were prospectively obtained from penile prostheses at revision surgery for any reason, between November 2000 and July 2012. Immediately upon surgical exposure of the pump, cultures were obtained. If a bacterial biofilm was noted on any component, it was additionally cultured. 258 patients had cultures taken at the time of revision surgery for any reason, only patients undergoing clinically uninfected revision/replacement surgeries with adequate data were included for a total cohort of 194 patients: 67 with infection retardant coated implants and 127 uncoated penile prostheses. RESULTS During revision surgery for non-infected IPP, culture positive bacteria was found in 93 of 127 (67%) patients with non coated IPP. Meanwhile, 40 of 67 (60%), of patients with coated IPPs showed positive cultures. Of the 93 non-coated patients, 81 (87%) had positive culture for Staphylococcus genus, while 30 (75%) of the 40 patients with coated IPP had a cultured isolate of the Staphylococcus genus. CONCLUSIONS Positive cultures and visible bacterial biofilm have been shown to be present on clinically uninfected IPPs at the time of revision surgery in the majority of patients whether or not the IPP is coated with infection retardant coating. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e685 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gerard Henry Shreveport, LA More articles by this author Chris Smith Shreveport, LA More articles by this author Steven Wilson Palm Springs, CA More articles by this author John Delk Little Rock, AR More articles by this author Mario Cleves Little Rock, AR More articles by this author Caroline Jennermann Shreveport, LA More articles by this author Culley Carson Chapel Hill, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Peyronie's Disease/Surgical Therapy II1 Apr 20121862 SINGLE COMPONENT EXCHANGE DURING PENILE PROSTHESIS REVISION APPEARS TO HAVE HIGHER INFECTION RATES AND LOWER OVERALL DEVICE SURVIVAL RATES THAN COMPLETE COMPONENT REPLACEMENT: A MULTICENTER ANALYSIS Gerard Henry, Steven K. Wilson, Craig Donatucci, John Delk, Aaron Lentz, Erin McNamara, Mario Cleves, Caroline Jennerman, and Culley Carson Gerard HenryGerard Henry Shreveport, LA More articles by this author , Steven K. WilsonSteven K. Wilson Indio, CA More articles by this author , Craig DonatucciCraig Donatucci Durham, NC More articles by this author , John DelkJohn Delk Little Rock, AR More articles by this author , Aaron LentzAaron Lentz Durham, NC More articles by this author , Erin McNamaraErin McNamara Durham, NC More articles by this author , Mario ClevesMario Cleves Little Rock, AR More articles by this author , Caroline JennermanCaroline Jennerman Shreveport, LA More articles by this author , and Culley CarsonCulley Carson Chapel Hill, NC More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1974AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Anecdotally, many prosthetic urology surgeons have strong feelings about single component exchange versus complete replacement of a three-piece inflatable penile prosthesis (IPP), in terms of infection and device survival rates, but there is a dearth of knowledge in the published literature on the subject. In addition, it is now known that the majority of penile prostheses have culture-positive bacteria at the time of revision surgery, indicating that bacteria probably exists on any IPP components that are retained (J Urol 172: 153). We evaluated infection rates and overall device survival rates, comparing single component exchange and complete replacement of IPPs at the time of revision surgery for non-infectious reasons. METHODS At 4 institutions, 227 patients with a penile prosthesis underwent revision surgery between November 2000 and April 2011. Strict criteria were utilized. Only patients who were undergoing single component exchange of their existing IPP or complete removal and replacement with a new IPP and had adequate follow-up were included. Patients were excluded if their revision surgery was for infection, erosion, impending erosion, extrusion, hemotoma removal, grafting, hydrocapsulotomy, bladder erosion, or concurrent surgeries. Of the 227 patients, 148 (65%) qualified for analysis: 13 in the single component exchange (group 1) and 135 in the complete removal and replacement with a new IPP (group 2). Infection rates and overall device survival rates were calculated by a PhD-level statistician. RESULTS Though not powered enough for statistical significance, the results trended towards better outcomes with the complete replacement patients (group 2). For overall device survival (any complication), 8 of the 135 (5.93%) in group 2 failed, while 2 of the 13 (15.38%) in group 1 failed, with Fisher's exact p-value = 0.214 and Log-rank test p-value = 0.475. A greater trend towards significance was found when evaluating for infection rates with 5 of the 135 (3.7%) in group 2 becoming infected and 2 of the 13 (15.38%) in group 1 becoming infected, a Fisher's exact p-value = 0.116 and a Log-rank test p-value = 0.254. CONCLUSIONS Complete penile prosthesis removal and replacement may have lower infection and higher device survival rates as compared with exchange of a single component. A causal factor may be bacteria on the retained component(s). A larger study group is needed to determine statistical significance. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e752-e753 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gerard Henry Shreveport, LA More articles by this author Steven K. Wilson Indio, CA More articles by this author Craig Donatucci Durham, NC More articles by this author John Delk Little Rock, AR More articles by this author Aaron Lentz Durham, NC More articles by this author Erin McNamara Durham, NC More articles by this author Mario Cleves Little Rock, AR More articles by this author Caroline Jennerman Shreveport, LA More articles by this author Culley Carson Chapel Hill, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

INTRODUCTION This study was conducted to determine how long after inflatable penile prosthesis (IPP) surgery patients attempt sexual intercourse and the frequency of subsequent relations. We also examined survival-related factors for the AMS 700 CX, Mentor Alpha 1, and Mentor Alpha Narrow Base. AIMS The aim was to survey men who received IPPs and collect information about their return to sexual function and frequency of use, and to assess the resilience of their devices. METHODS Phase I involved retrospective chart review of 1,298 virgin IPP surgeries performed by one surgical team from January 1992 to December 1998. Phase II included 330 subjects selected by stratified, systematic, random sampling from phase I patients. Data were collected by computer-assisted telephone interview, using a 27-question survey. All patients had been instructed to wait 4 weeks before using the implant and were taught how to inflate/deflate their prostheses at the 4-week postsurgical visits. MAIN OUTCOME MEASURES The survey examines the length of time after surgery for men to resume sexual function. In the same study, information was garnered about mechanical durability of the device. RESULTS Among phase I subjects, the 5-year survival rate was 83% (N = 1,069) for IPP revision for any reason. Of the 330 phase II subjects, 248 (75%) were successfully contacted; 199 (80%) responded to the full survey and 49 (20%) responded to selected parts of the survey. Sexual intercourse was resumed postoperatively at 1-4 weeks for 41% (78/190), at 5-6 weeks for 31% (59/190), at 7-8 weeks for 16% (30/190), and at >8 weeks for 12% (23/190) of the patients. More than 60% of patients reported using their IPP at least once weekly. CONCLUSION The three-piece IPP has excellent 5-year survival rates. Most patients return to sexual activity relatively quickly, with high frequency of usage of their prostheses.

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Peyronie's Disease/Surgical Therapy1 Apr 20111801 POSITIVE CULTURE GROWTHS FROM INFECTION RETARDANT-COATED PENILE PROSTHESES AT THE TIME OF REVISION/SAVLAGE SURGERY: A MULTICENTER STUDY Gerard Henry, Culley Carson, John Delk, Stephen McKim, Erin McNamara, Mario Cleves, Caroline Simmons, Anthony Bella, and Craig Donatucci Gerard HenryGerard Henry Shreveport, LA , Culley CarsonCulley Carson Chapel Hill, NC , John DelkJohn Delk Indio, CA , Stephen McKimStephen McKim Chapel Hill, NC , Erin McNamaraErin McNamara Durham, NC , Mario ClevesMario Cleves Little Rock, AR , Caroline SimmonsCaroline Simmons Little Rock, AR , Anthony BellaAnthony Bella Ottawa, Canada , and Craig DonatucciCraig Donatucci Durham, NC View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2173AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Traditionally, the most common bacteria found at the time of inflatable penile prosthesis (IPP) infection was staphylococcus (S.) species. In the past few years, infection retardant-coated IPPs have been shown to reduce primary (virgin) infection rates by about half. There has been speculation that these infection retardant-coatings may change the nature of what culture isolates will grow in the presence of these coating that are suppose to help prevent colonization of the implants. The majority of penile prostheses have culture positive bacteria at the time of revision surgery (J Urol 172: 153). We evaluated culture isolates from patients with known infection retardant-coated IPPs to evaluate the bacterial profile. METHODS At 4 institutions, more than 200 patients with a penile prosthesis underwent revision surgery between November 2000 and November 2009. Only those patients who already had infection retardant-coated penile prostheses placed and grew out positive culture isolates were included in the study. Patients were further broken down into two groups: clinically uninfected revision/replacement (group 1 = 40 patients) and overtly infected undergoing salvage rescue or removal (group 2 = 17 patients). In addition, sensitivities to the combination of tetracycline and rifampin were evaluated (sensitive = sens; resistant = R). RESULTS A total of 38 isolates were cultured out these patients with 25 from group 1 and 13 from group 2; some patients grew out more than one isolate. Culture positive isolates from the clinically uninfected revisions (group 1) were 16 S. Epi (all sens), 3 S. Lugdenesis (all sens), enterococcus faecalis (intermediate sens), Klebsiella pneumonia (sens), yeast, Micrococcus species, Gram + rods, peptostreptococcus species. Culture positive isolates from overtly infected patients (group 2) were 4 S. Epi (all sens), 2 MRSA (sens), 2 Enterococcus Faecalis (sens), S. Haemolyicus, S. Warneri, yeast, E. Coli (tetracycline R), Citrobacter Freudii (R to rifampin). CONCLUSIONS Culture isolates grown from patients undergoing revision surgery for clinically uninfected (group 1) reasons appear to have a more traditional bacteria profile; meanwhile, those patients with overt infections (group 2) may have a non-traditional bacterial profile. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byMuench P (2012) Infections Versus Penile Implants: The War on BugsJournal of Urology, VOL. 189, NO. 5, (1631-1637), Online publication date: 1-May-2013. Volume 185Issue 4SApril 2011Page: e723 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Metrics Author Information Gerard Henry Shreveport, LA More articles by this author Culley Carson Chapel Hill, NC More articles by this author John Delk Indio, CA More articles by this author Stephen McKim Chapel Hill, NC More articles by this author Erin McNamara Durham, NC More articles by this author Mario Cleves Little Rock, AR More articles by this author Caroline Simmons Little Rock, AR More articles by this author Anthony Bella Ottawa, Canada More articles by this author Craig Donatucci Durham, NC More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

INTRODUCTION Parylene coating was added to the silicone layers of the American Medical Systems (AMS) 700 controlled expansion (CX) penile prosthesis cylinders in January 2001. The coating was placed on non-tissue contacting silicone surfaces to increase lubricity, reduce friction, and silicone wear AIM We compared mechanical reliability of the original and Parylene-enhanced AMS 700 CX in a large single surgical group series. METHODS Seven hundred seventy-five consecutive patients receiving the AMS 700CX prosthesis (596 first time [virgin] and 179 revisions) were followed for 3 years. Four hundred fourteen received the non-coated model and 361 received the Parylene-coated device. Revision-free survival was estimated using the Kaplan-Meier product limit method and compared using the log-rank test. MAIN OUTCOME MEASURES We calculated overall survival from revision for any reason and survival from mechanical problems such as fluid leakage, cylinder, connector or tubing breakage, pump or reservoir defects. RESULTS For the entire series (virgin + revised) the 3-year revision free survival for any cause improved from 78.6% for non-coated to 87.4% for the Parylene-coated implants. Freedom from mechanical breakage showed similar improvement from 89.2% for the non-coated to 97.5% for enhanced models. CONCLUSIONS This study documents that short-term mechanical reliability and survival from revision for any cause is significantly increased with Parylene-coated AMS 700CX cylinders compared with the earlier AMS 700CX model with non-coated cylinders.

INTRODUCTION:A single-armed, prospective, multicenter study evaluated the redesigned American Medical Systems (AMS) 700 Momentary Squeeze (MS) pump inflatable penile prosthesis (IPP) with enhanced features for ease of implantation and patient manipulation. The device incorporates design changes to all components: pump, cylinders, rear-tip extenders, and reservoir. AIM:To assess physician and patient satisfaction with the new AMS 700 MS pump. METHODS:Patients were selected from the existing population experiencing erectile dysfunction (ED) without previous prosthetic implantation. MAIN OUTCOME MEASURES:Survey questionnaires were used to capture physician feedback on ease of implantation and patient education. Patient satisfaction with the device and existence of autoinflation were assayed. RESULTS:Sixty-nine patients were implanted at seven U.S. sites. Mean age was 60.1 +/- 9.6 years. History of ED was >5 years in 34 (44.7%) patients. Main ED etiology was organic, nonspecific (32%). Eighty-four percent of the physicians felt proximal cylinder insertion was easier because of the smaller angle of cylinder input tubing and narrower base diameter. The new pump was felt easier to implant than the previous model by 57% of the physicians. The patients found the manipulation of the pump simple at device activation, with 96% easily locating the inflation bulb and 94% deflating the device with one push of the deflation button. Reviews were mixed among physicians concerning ease of training compared with the Tactile pump. Patient training was easier in 71%, harder in 21%, and same in 8%. Nevertheless, 67% of the patients were trained in 6 minutes or less. At 6 months, 77% of the patients were very satisfied, 9% somewhat satisfied, and 14% dissatisfied. Autoinflation occurred in two patients (3%). CONCLUSION:The new AMS 700 MS IPP seems a distinct improvement over previous devices with most physicians feeling implantation and patient instruction were easier. The device also satisfied 86% of the users and virtually eliminated autoinflation.

Parylene coating was added to the silicone layers of the AMS 700 CX penile prosthesis cylinders in January 2001. The coating was placed on non-tissue contacting silicone surfaces to increase lubricity, reduce friction and silicone wear. We compare mechanical reliability of the original and Parylene enhanced AMS 700 CX in a large single surgical group series

Introduction. Long-term revision-free survival, greater than 10 years has never been reported for inflatable penile prostheses. We conducted a historical prospective study to estimate 10 and 15 years survival of first time (virgin) implantations in 2,384 patients with four different models.Aim. Evaluation of 10- and 15-year mechanical and overall revision-free survival of inflatable penile prostheses.Main Outcome Measures. Kaplan-Meier product limit method, and comparison using the log rank test, were used to estimate the 10- and 15-year revision-free survival.Methods. Data were obtained from medical records and patient interviews, entered into a computerized database, and analyzed by a third party. Information included implant type, date, revision history with date, and reason. Fourteen different inflatables were examined. Mentor Alpha 1, Mentor Alpha NB, AMS 700 CX, and AMS 700 Ultrex had usage for an extended period of time. Because of failure times being confounded as a result of prior implants, only virgin implants were examined.Results. For the entire series, estimated 10-year revision-free survival for all reasons was 68.5% and the 15-year revision-free survival was 59.7%. Freedom from mechanical breakage at 10 years was 79.4%; 15 years was 71.2%. Recent mechanically enhanced models did even better. In 1992, Mentor Alpha added pump reinforcement to forestall mechanical breakage. This improved 10-year survival from 65.3% to 88.6% (P = 0.0001). In January 2001, AMS CX added a parylene coating to the cylinders that increased 3-year mechanical survival from 88.4 to 97.9% (P = 0.0002).Conclusions. This is the first report on long-term reliability of inflatable penile prostheses. We estimated 60% of these virgin implants would survive 15 or more years without revision or extraction. Newer enhanced models are currently available, and our tracking predicts even better long-term survival for these devices.

Objectives Inflatable penile prosthesis (IPP) infection remains a devastating surgical complication. American Medical Systems recently introduced an IPP with a coating of minocycline HCL and rifampin (InhibiZone). We report our experience with this coating and compare the rate of infection with our historical rate.Methods A total of 467 patients receiving InhibiZone-coated IPPs were followed up for infection. The patients were stratified into four groups: nondiabetic, first-time (virgin) implants; diabetic, virgin implants; revision without washout; and revision with antiseptic solution washout. All patients were observed for longer than I year. The infection rates were compared with our published data of noncoated IPPs.Results No infections developed among the 223 virgin implants in nondiabetic patients. Of the 83 diabetic patients with virgin implants, 1 developed an infection (1%). Of the 39 revision patients without washout, 4 (10%) had infections. When an antiseptic washout was used in patients requiring revision, the infection rate dropped to 3% (4 of 123). Compared with our previous publications of infection rates with noncoated implants, InhibiZone-coated IPPs showed a statistically significant reduction in infection in virgin nondiabetic, virgin diabetic, and revision with washout implants. No reduction in the infection rate occurred among revision patients without washout.Conclusions Antibiotic-coated implants become infected less often in virgin, nondiabetic and virgin, diabetic patients than in our historical experience with noncoated implants. However, antibiotic-coated implants used in revision surgery did not reduce the infection rate unless adjunctive antiseptic solution washout was also used.

INTRODUCTION:Premature ejaculation (PE) is a worldwide problem without an approved treatment. Selective serotonin reuptake inhibitors (SSRIs) are widely used "off label" as pharmacotherapeutic agents in the treatment of PE. AIM:This study investigates Tramadol efficacy for on-demand treatment of PE. MAIN OUTCOMES MEASURES:Intravaginal ejaculation latency time (IELT) was used as an objective tool to assess the efficacy of the investigated treatments. MATERIALS AND METHODS:Single-blind, placebo-controlled, crossover, stopwatch monitored two-period study was conducted, on 60 patients with lifelong PE. PE was defined as IELT of <2 minutes in 80% of intercourse episodes. A total of 25 mg of Tramadol hydrochloride was given to one group (30) prior to intercourse and placebo was supplied for the other group (30) for 8 weeks. Drugs were taken 1-2 hours before sexual activity and sexual intercourse was required at least once per week. After the initial treatment period, the two groups took the alternate medication for another 2 months. The two 8-week treatment periods were separated by 1 week washout period. IELT was timed by a stopwatch at each intercourse and was reported by patients or partners. RESULTS:The baseline (mean +/- SD) IELT for patients before treatment was 1.17 +/- 0.39 minutes. At the end of the treatment period utilizing the active drug, the mean IELT was increased significantly in patients on Tramadol treatment to 7.37 +/- 2.53 minutes. The same patients on placebo medication had mean IELT of only 2.01 +/- 0.71 minutes. Patients uniformly reported satisfaction with their resulting control over ejaculation. CONCLUSIONS:Tramadol, a drug with a proven safety record as an anti-inflammatory agent, shows promise as a drug for treating rapid ejaculation.

You have accessJournal of UrologyModerated Poster 28, Monday, May 21, 2007, 1:00 - 3:00 pm1 Apr 2007938: Parylene Coating Improves Mechanical Survival of AMS 700CX Penile Prosthesis Eamd A. Salem, Steven K. Wilson, John R. Delk, and Mario A. Cleves Eamd A. SalemEamd A. Salem , Steven K. WilsonSteven K. Wilson , John R. DelkJohn R. Delk , and Mario A. ClevesMario A. Cleves View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31166-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "938: Parylene Coating Improves Mechanical Survival of AMS 700CX Penile Prosthesis." The Journal of Urology, 177(4S), p. 311 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 311 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Eamd A. Salem More articles by this author Steven K. Wilson More articles by this author John R. Delk More articles by this author Mario A. Cleves More articles by this author Expand All Advertisement Loading ...